3.4.21.79: granzyme B

This is an abbreviated version!
For detailed information about granzyme B, go to the full flat file.

Word Map on EC 3.4.21.79

3.4.21.79

perforin

t-cells

cd8

cytolytic

immunotherapy

vaccine

lymphoma

rejection

tnf

dendritic

cell-mediated

ifn-gamma

allograft

tregs

tia-1

fasl

foxp3

autologous

interferon-gamma

caspases

degranulation

allogeneic

epstein-barr

antigen-specific

virus-specific

immunophenotype

ctla-4

anti-cd3

tumor-infiltrating

nk-cell

extranodal

elispot

synthesis

eomes

graft-versus-leukemia

cd45ro

alcls

biotechnology

death-1

analysis

intragraft

lag-3

hiv-specific

medicine

diagnostics

degradation

alloreactive

lymphocyte-mediated

lymphokine-activated

crma

b-mediated

pharmacology

ag-specific

banff

hepatosplenic

anti-pd-1

interleukin-15

Reaction

preferential cleavage: -Asp-/- >> -Asn-/- > -Met-/-, -Ser-/- =

Synonyms

Asp-ase, C11, CCP1, CCPII, CTLA1, CTSGL1, Cytotoxic cell proteinase-1, cytotoxic lymphocyte-associated protease, cytotoxic lymphocyte-specific protein, cytotoxic serine protease granzyme B, cytotoxic T-lymphocyte-associated gene transcript-1, gB, Gra-b, granzyme B, Granzyme G, Granzyme H, GrB, GrzmB, GzB, Gzm, Gzm B, GzmB, GzmB-like enzyme, GzmH, HLp, Human lymphocyte protein, Lymphocyte protease, natural killer cell protease 1, pro-apoptotic serine protease, proGrB, Proteinase, CCP1, rat grB[N66Q], SECT, T-cell serine protease 1-3E

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.21 Serine endopeptidases

3.4.21.79 granzyme B

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Results	in table
24	Activating Compound
6	AA Sequence
55	Application
1	CAS Registry Number
31	Cloned(Commentary)
3	Crystallization (Commentary)
3468	Disease/ Diagnostics
15	Expression
54	General Information
7	IC50 Value
95	Inhibitors
3	kcat/KM [mM/s]
8	Ki Value [mM]
38	KM Value [mM]
24	Localization
7	Metals/Ions
16	Molecular Weight [Da]
49	Natural Substrates/ Products (Substrates)
142	Organism
3	PDB ID
13	pH Optimum
1	pH Range
6	Posttranslational Modification
56	Protein Variants
32	Purification (Commentary)
1	Reaction
1	Reaction Type
140	Reference
165	Source Tissue
3	Specific Activity [micromol/min/mg]
2	Storage Stability
360	Substrates and Products (Substrate)
9	Subunits
117	Synonyms
7	Temperature Optimum [°C]
24	Turnover Number [1/s]

KI Value

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KI Value on EC 3.4.21.79 - granzyme B

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0.013

(2S,5S)-4-oxo-5-[[N-(phenylacetyl)-L-isoleucyl]amino]-N-(1H-1,2,3-triazol-4-ylmethyl)-1,2,4,5,6,7-hexahydroazepino[3,2,1-hi]indole-2-carboxamide

Homo sapiens

P10144

pH 7.4, 30°C

732601

0.038

(2S,5S)-5-[(N-acetyl-L-isoleucyl)amino]-4-oxo-N-(1H-1,2,3-triazol-4-ylmethyl)-1,2,4,5,6,7-hexahydroazepino[3,2,1-hi]indole-2-carboxamide

Homo sapiens

P10144

pH 7.4, 30°C

732601

0.000007

(2S,5S)-5-[[N-(1-benzothiophen-3-ylacetyl)-L-isoleucyl]amino]-4-oxo-N-(1H-1,2,3-triazol-4-ylmethyl)-1,2,4,5,6,7-hexahydroazepino[3,2,1-hi]indole-2-carboxamide

Homo sapiens

P10144

pH 7.4, 30°C

732601

0.000008 - 0.000025

(S)-3-((2S,5S)-5-((2S,3S)-2-acetamido-3-methylpentanamido)-4-oxo-1,2,4,5,6,7-hexahydroazepino[3,2,1-hi]indole-2-carboxamido)-4-oxobutanoic acid

2 entries

0.0084 - 0.0123

Boc-Ile-Glu-Ala-Asp-CONH(CH2)2-Ph

2 entries

0.08

N-acetyl-L-isoleucyl-L-alpha-glutamyl-N-[(2S)-1-carboxy-3-oxopropan-2-yl]-L-prolinamide

Homo sapiens

P10144

pH 7.4, 30°C

732601