Disease on EC 3.4.21.79 - granzyme B

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Abortion, Spontaneous
CD49a regulates the function of human decidual natural killer cells.
Granulysin produced by uterine natural killer cells induces apoptosis of extravillous trophoblasts in spontaneous abortion.
Large granular lymphocytes (LGLS) activity in women with spontaneous abortions during the 1st trimester of gestation.
Acute Coronary Syndrome
Granzyme B as a novel factor involved in cardiovascular diseases.
Increased granzyme B production from peripheral blood mononuclear cells in patients with acute coronary syndrome.
Plasma granzyme B in ST elevation myocardial infarction versus non-ST elevation acute coronary syndrome: comparisons with IL-18 and fractalkine.
Acute Lung Injury
Fas/FasL-dependent apoptosis of alveolar cells after lipopolysaccharide-induced lung injury in mice.
Granzyme B deficiency exacerbates lung inflammation in mice after acute lung injury.
Acute-On-Chronic Liver Failure
NKG2D modulates aggravation of liver inflammation by activating NK cells in HBV infection.
Adenocarcinoma
Generation of recombinant canine interleukin-15 and evaluation of its effects on the proliferation and function of canine NK cells.
TRAIL-Receptor 4 Modulates ?? T Cell-Cytotoxicity Toward Cancer Cells.
Adenocarcinoma of Lung
Estrogen and cigarette sidestream smoke particulate matter exhibit ER?-dependent tumor-promoting effects in lung adenocarcinoma cells.
Albuminuria
Anti-CD8 monoclonal antibody therapy is effective in the prevention and treatment of experimental autoimmune glomerulonephritis.
Alopecia
Induction of alopecia areata in C3H/HeJ mice using cryopreserved lymphocytes.
Type 1 interferon signature in the scalp lesions of alopecia areata.
Alopecia Areata
Role of cytotoxic T cells in chronic alopecia areata.
Type 1 interferon signature in the scalp lesions of alopecia areata.
Anemia, Aplastic
Involvement of cytotoxic granules in the apoptosis of aplastic anaemia.
Aneurysm
CD8 T lymphocytes do not express cytotoxic proteins in coronary artery aneurysms in acute Kawasaki disease.
Angina, Unstable
Increased granzyme B production from peripheral blood mononuclear cells in patients with acute coronary syndrome.
Anthrax
Proteases as activators for cytotoxic prodrugs in antitumor therapy.
Aortic Aneurysm
Structural and biomolecular changes in aorta and pulmonary trunk of patients with aortic aneurysm and valve disease: implications for the Ross procedure.
Aortic Aneurysm, Abdominal
Perforin-independent extracellular granzyme B activity contributes to abdominal aortic aneurysm.
Appendicitis
Immunohistochemical analysis of granzyme B in non-perforated appendicitis--short communication.
Arthritis
Monoclonal anti-CD8 therapy induces disease amelioration in the K/BxN mouse model of spontaneous chronic polyarthritis.
Raised granzyme B levels are associated with erosions in patients with early rheumatoid factor positive rheumatoid arthritis.
Arthritis, Rheumatoid
A genetic variant in granzyme B is associated with progression of joint destruction in rheumatoid arthritis.
Chronic clonal proliferative disease of gamma-delta (gammadelta) T-cells in a patient with rheumatoid arthritis and neutropenia: lack of the morphology and the immunophenotype of large granular lymphocytes.
Crystal structure of the caspase activator human granzyme B, a proteinase highly specific for an Asp-P1 residue.
Elevated serum granzyme B levels are associated with disease activity and joint damage in patients with rheumatoid arthritis.
Etanercept reduces the serum levels of macrophage chemotactic protein-1 in patients with rheumatoid arthritis.
Expression of granzyme B in human articular chondrocytes.
Granzyme B and natural killer (NK) cell death.
Granzyme B induces apoptosis of chondrocytes with natural killer cell-like cytotoxicity in rheumatoid arthritis.
Human granzyme B mediates cartilage proteoglycan degradation and is expressed at the invasive front of the synovium in rheumatoid arthritis.
Macrophages express granzyme B in the lesion areas of atherosclerosis and rheumatoid arthritis.
Proteolysis by Granzyme B Enhances Presentation of Autoantigenic Peptidylarginine Deiminase 4 Epitopes in Rheumatoid Arthritis.
Raised granzyme B levels are associated with erosions in patients with early rheumatoid factor positive rheumatoid arthritis.
Serum levels of granzyme B decrease in patients with rheumatoid arthritis responding to abatacept.
Asthma
Altered sputum granzyme B and granzyme B/proteinase inhibitor-9 in patients with non-eosinophilic asthma.
Blood cytotoxic/inflammatory mediators in non-eosinophilic asthma.
Decrease of cytotoxic T cells in allergic asthma correlates with total serum immunglobulin E.
Granule Cytotoxic Activity and Oxidative DNA Damage in Smoking and Nonsmoking Patients With Asthma.
Granzyme B, a novel mediator of allergic inflammation: its induction and release in blood basophils and human asthma.
Increase in granzyme B+ lymphocytes and soluble granzyme B in bronchoalveolar lavage of allergen challenged patients with atopic asthma.
Lung function decline in asthma patients with elevated bronchial CD8, CD4 and CD3 cells.
Maternal diesel particle exposure promotes offspring asthma through NK cell-derived granzyme B.
Astrocytoma
Differential PARP cleavage: an indication for existence of multiple forms of cell death in human gliomas.
Ataxia Telangiectasia
Temporal changes in mouse aortic wall gene expression during the development of elastase-induced abdominal aortic aneurysms.
Atherosclerosis
Granzyme B in atherosclerosis and transplant vascular disease: association with cell death and atherosclerotic disease severity.
Macrophages express granzyme B in the lesion areas of atherosclerosis and rheumatoid arthritis.
Perforin and granzyme B have separate and distinct roles during atherosclerotic plaque development in apolipoprotein E knockout mice.
Peripheral leucocytes and tissue gene expression of granzyme B/perforin system and serpinB9: Impact on inflammation and insulin resistance in coronary atherosclerosis.
The role of Granzyme B in atheromatous diseases.
Autoimmune Diseases
Cleavage by granzyme B is strongly predictive of autoantigen status: implications for initiation of autoimmunity.
Contribution to antimitochondrial antibody production: cleavage of pyruvate dehydrogenase complex-E2 by apoptosis-related proteases.
Granzyme B and natural killer (NK) cell death.
Granzyme B is dispensable for immunologic tolerance to self in a murine model of systemic lupus erythematosus.
Granzyme B production distinguishes recently activated CD8(+) memory cells from resting memory cells.
Increase in activated CD8+ T lymphocytes expressing perforin and granzyme B correlates with disease activity in patients with systemic lupus erythematosus.
Unique conformation of cancer autoantigen B23 in hepatoma: a mechanism for specificity in the autoimmune response.
Bacterial Infections
Modulation of the granzyme B inhibitor proteinase inhibitor 9 (PI-9) by activation of lymphocytes and monocytes in vitro and by Epstein-Barr virus and bacterial infection.
Bacteriuria
Transcriptional profiles in urine during acute rejection, bacteriuria, CMV infection and stable graft function after renal transplantation.
Bicuspid Aortic Valve Disease
Structural and biomolecular changes in aorta and pulmonary trunk of patients with aortic aneurysm and valve disease: implications for the Ross procedure.
Blister
Collagen XVII Processing and Blistering Skin Diseases.
Delayed reactions to drugs show levels of perforin, granzyme B, and Fas-L to be related to disease severity.
Granulysin is a key mediator for disseminated keratinocyte death in Stevens-Johnson syndrome and toxic epidermal necrolysis.
Granzyme B inhibition reduces disease severity in autoimmune blistering diseases.
Toxic epidermal necrolysis: effector cells are drug-specific cytotoxic T cells.
Brain Diseases
Granzyme A Participates in the Pathogenesis of Infection-Associated Acute Encephalopathy.
Brain Infarction
Granzyme-b is involved in mediating post-ischemic neuronal death during focal cerebral ischemia in rat model.
Brain Injuries
CTL-Derived Granzyme B Participates in Hippocampal Neuronal Apoptosis Induced by Cardiac Arrest and Resuscitation in Rats.
Brain Ischemia
Cleaved ?-Actin May Contribute to DNA Fragmentation Following Very Brief Focal Cerebral Ischemia.
Differential PARP Cleavage: An Indication of Heterogeneous Forms of Cell Death and Involvement of Multiple Proteases in the Infarct of Focal Cerebral Ischemia in Rat.
Granzyme-b is involved in mediating post-ischemic neuronal death during focal cerebral ischemia in rat model.
Breast Diseases
Analysis of the mononuclear inflammatory cell infiltrate in the normal breast, benign proliferative breast disease, in situ and infiltrating ductal breast carcinomas: preliminary observations.
Breast Neoplasms
Actin Cytoskeleton Remodeling Drives Breast Cancer Cell Escape from Natural Killer-Mediated Cytotoxicity.
An Oncolytic Adenovirus Targeting Transforming Growth Factor ? Inhibits Protumorigenic Signals and Produces Immune Activation: A Novel Approach to Enhance Anti-PD-1 and Anti-CTLA-4 Therapy.
Apoptosis Markers in Breast Cancer Therapy.
Defective gammadelta T-cell function and granzyme B gene polymorphism in a cohort of newly diagnosed breast cancer patients.
Epirubicin pretreatment enhances NK cell-mediated cytotoxicity against breast cancer cells in vitro.
Expression of endogenous granzyme B in a subset of human primary breast carcinomas.
Interplay between the levels of estrogen and estrogen receptor controls the level of the granzyme inhibitor, proteinase inhibitor 9 and susceptibility to immune surveillance by natural killer cells.
Involvement of granzyme B and perforin in suppressing nodal metastasis of cancer cells in breast and lung cancers.
Low concentrations of the soy phytoestrogen genistein induce proteinase inhibitor 9 and block killing of breast cancer cells by immune cells.
MICA-G129R: A bifunctional fusion protein increases PRLR-positive breast cancer cell death in co-culture with natural killer cells.
Serum levels of soluble Fas ligand, granzyme B and cytochrome c during adjuvant chemotherapy of breast cancer.
The pharmalogical reactivation of p53 function improves breast tumor cell lysis by granzyme B and NK cells through induction of autophagy.
TLR-activated plasmacytoid dendritic cells inhibit breast cancer cell growth in vitro and in vivo.
Bronchiolitis
Lymphocytic bronchiolitis is associated with inadequate suppression of blood T-cell granzyme B, IFN-gamma, and TNF-alpha.
Bronchiolitis Obliterans
Bronchiolitis obliterans syndrome is associated with increased peripheral blood natural killer and natural killer T-like granzymes, perforin, and T-helper-type 1 pro-inflammatory cytokines.
Increased levels of T cell granzyme b in bronchiolitis obliterans syndrome are not suppressed adequately by current immunosuppressive regimens.
Targeting peripheral blood pro-inflammatory CD28null T cells and natural killer T-like cells by inhibiting CD137 expression: Possible relevance to treatment of bronchiolitis obliterans syndrome.
Up-regulation of alternate co-stimulatory molecules on proinflammatory CD28null T cells in bronchiolitis obliterans syndrome.
Carcinogenesis
Immune response and evasion mechanisms in lip carcinogenesis: An immunohistochemical study.
Carcinoma
A comparative study of granzyme B expression in keratoacanthoma and squamous cell carcinoma.
Alterations in signal transduction molecules in T lymphocytes from tumor-bearing mice.
Characterization of immunoreactivity with whole-slide imaging and digital analysis in high-grade serous ovarian cancer.
Comprehensive analysis of marker gene detection and computed tomography for the diagnosis of human lung cancer.
Correlation of P53 and Granzyme B expression in Oral Squamous Cell Carcinoma with Clinicopathologic Findings.
Defective granzyme B gene expression and lytic response in T lymphocytes infiltrating human renal cell carcinoma.
Distinct expression of perforin and granzyme B in lip and oral cavity squamous cell carcinoma.
DNAX-activating protein 10 co-stimulation enhances the anti-tumor efficacy of chimeric antigen receptor T cells.
Docosahexaenoic acid inhibits invasion of human RT112 urinary bladder and PT45 pancreatic carcinoma cells via down-modulation of granzyme B expression.
Enhanced apoptosis of squamous cell carcinoma cells by interleukin-2-activated cytotoxic lymphocytes combined with radiation and anticancer drugs.
Granzyme B is expressed in urothelial carcinoma and promotes cancer cell invasion.
Granzyme B-truncated VEGF fusion protein represses angiogenesis and tumor growth of OSCC.
High levels of granzyme B expression in invasive cervical carcinoma correlates to poor response to treatment.
Immunohistochemical localization of granzyme B in peritumoral infiltrates of basal cell carcinoma.
Implication of caspase-3 and granzyme B expression and activity in spleenocytes of ehrlich ascites carcinoma mice subjected to immunotherapy.
Increased frequency of Foxp3+ regulatory T cells in mice with hepatocellular carcinoma.
Lack of granzyme expression in T lymphocytes indicates poor cytotoxic T lymphocyte activation in human papillomavirus-associated cervical carcinomas.
Perforin and granzyme B induce apoptosis in FasL-resistant colon carcinoma cells.
Solid tumor-targeted infiltrating cytotoxic T lymphocytes retained by a superantigen fusion protein.
Synergy between hemagglutinin 2 (HA2) subunit of influenza fusogenic membrane glycoprotein and oncolytic Newcastle disease virus suppressed tumor growth and further enhanced by Immune checkpoint PD-1 blockade.
T cell receptor-zeta and granzyme B expression in mononuclear cell infiltrates in normal colon mucosa and colon carcinoma.
The clinicopathological significance of the expression of Granzyme B in oral squamous cell carcinoma.
Trichosanthin cooperates with Granzyme B to restrain tumor formation in tongue squamous cell carcinoma.
Tumor infiltrating lymphocytes differ in invasive micropapillary carcinoma and medullary carcinoma of breast.
Carcinoma, Basal Cell
Immunohistochemical localization of granzyme B in peritumoral infiltrates of basal cell carcinoma.
Carcinoma, Ductal
Analysis of the mononuclear inflammatory cell infiltrate in the normal breast, benign proliferative breast disease, in situ and infiltrating ductal breast carcinomas: preliminary observations.
Carcinoma, Hepatocellular
Dynamic conformations of nucleophosmin (NPM1) at a key monomer-monomer interface affect oligomer stability and interactions with granzyme B.
Enhanced Cancer Immunotherapy with Smad3-Silenced NK-92 Cells.
Mutations to bid cleavage sites protect hepatocytes from apoptosis after ischemia/reperfusion injury.
Carcinoma, Intraductal, Noninfiltrating
Analysis of the mononuclear inflammatory cell infiltrate in the normal breast, benign proliferative breast disease, in situ and infiltrating ductal breast carcinomas: preliminary observations.
Carcinoma, Large Cell
Comprehensive analysis of marker gene detection and computed tomography for the diagnosis of human lung cancer.
Carcinoma, Medullary
Tumor infiltrating lymphocytes differ in invasive micropapillary carcinoma and medullary carcinoma of breast.
Carcinoma, Mucoepidermoid
Immunohistochemical investigations on the expression of programmed cell death ligand 1, human leukocyte antigens G and E, and granzyme B in intraoral mucoepidermoid carcinoma.
Carcinoma, Non-Small-Cell Lung
Frequent T cell responses against immunogenic targets in lung cancer patients for targeted immunotherapy.
Carcinoma, Renal Cell
Defective granzyme B gene expression and lytic response in T lymphocytes infiltrating human renal cell carcinoma.
Carcinoma, Squamous Cell
A comparative study of granzyme B expression in keratoacanthoma and squamous cell carcinoma.
Distinct expression of perforin and granzyme B in lip and oral cavity squamous cell carcinoma.
Enhanced apoptosis of squamous cell carcinoma cells by interleukin-2-activated cytotoxic lymphocytes combined with radiation and anticancer drugs.
Trichosanthin cooperates with Granzyme B to restrain tumor formation in tongue squamous cell carcinoma.
[The effect of human PBMC on the growth of oral squamous cell carcinoma cell].
Cardiovascular Diseases
Granzyme B as a novel factor involved in cardiovascular diseases.
Predictive ability of granzyme B for cardiovascular disease and its direction in change.
Celiac Disease
Decreased expression of protease inhibitor 9, a granzyme B inhibitor, in celiac disease: a potential mechanism in enterocyte destruction and villous atrophy.
Evidence that intestinal intraepithelial lymphocytes are activated cytotoxic T cells in celiac disease but not in giardiasis.
Cervical Intraepithelial Neoplasia
Granzyme B as a prognostic marker of cervical intraepithelial neoplasia.
LC3B upregulation by NANOG promotes immune resistance and stem-like property through hyperactivation of EGFR signaling in immune-refractory tumor cells.
Chagas Disease
Characterization of CD4(+) Cytotoxic Lymphocytes and Apoptosis Markers Induced by Trypanossoma cruzi Infection.
Differential phenotypic and functional profiles of TcCA-2 -specific cytotoxic CD8+ T cells in the asymptomatic versus cardiac phase in Chagasic patients.
Identification of phenotypic markers of B cells from patients with Chagas disease.
Chickenpox
Granzyme B cleaves multiple HSV-1 and VZV gene products and VZV ORF4 inhibits Natural Killer cell dependent cytotoxicity.
Choriocarcinoma
Immune cell profiling in intraplacental and postmolar choriocarcinomas.
Choroiditis
ZIKA virus infection causes persistent chorioretinal lesions.
Coinfection
Coordinated In Vitro Release of Granulysin, Perforin and IFN-? in TB and HIV/TB Co-Infection Associated with Clinical Outcomes before and after Anti-TB Treatment.
Kinetics of Primary and Memory Cytotoxic T Lymphocyte Responses to Herpes Simplex Virus 1 Infection: Granzyme B Mediated CTL Activity.
Colitis
AHR Activation Is Protective against Colitis Driven by T Cells in Humanized Mice.
Evaluation of immune infiltration in the colonic mucosa of patients with ipilimumab-related colitis.
Colitis, Ulcerative
Differential levels of granzyme B, regulatory cytokines, and apoptosis in Crohn's disease and ulcerative colitis at first presentation.
Enhanced intramucosal cytotoxic lymphocyte gene expression in ulcerative colitis.
Colonic Neoplasms
B7-H5 blockade enhances CD8+ T-cell-mediated antitumor immunity in colorectal cancer.
Granzyme B PET Imaging of Combined Chemotherapy and Immune Checkpoint Inhibitor Therapy in Colon Cancer.
Granzyme B PET Imaging of Immune Checkpoint Inhibitor Combinations in Colon Cancer Phenotypes.
Liposomal Delivery of Mitoxantrone and a Cholesteryl Indoximod Prodrug Provides Effective Chemo-immunotherapy in Multiple Solid Tumors.
T lymphocyte SHP2-deficiency triggers anti-tumor immunity to inhibit colitis-associated cancer in mice.
Tim-3 suppresses the killing effect of V?9V?2?T cells on colon cancer cells by reducing perforin and granzyme B expression.
Tumor-derived granzyme B-expressing neutrophils acquire antitumor potential after lipid A treatment.
Wnt pathway activator TWS119 enhances the proliferation and cytolytic activity of human ??T cells against colon cancer.
Colorectal Neoplasms
Combination Therapy with EpCAM-CAR-NK-92 Cells and Regorafenib against Human Colorectal Cancer Models.
Cytotoxic T Cells and Granzyme B Associated with Improved Colorectal Cancer Survival in a Prospective Cohort of Older Women.
Epitelial-to-mesenchimal transition and invasion are upmodulated by tumor-expressed granzyme B and inhibited by docosahexaenoic acid in human colorectal cancer cells.
Granzyme B gene polymorphisms, colorectal cancer risk, and metastasis.
Lipid accumulation impairs natural killer cell cytotoxicity and tumor control in the postoperative period.
Low expression of Granzyme B in colorectal cancer is associated with signs of early metastastic invasion.
Sequential metastases of colorectal cancer: Immunophenotypes and spatial distributions of infiltrating immune cells in relation to time and treatments.
T cell receptor-zeta and granzyme B expression in mononuclear cell infiltrates in normal colon mucosa and colon carcinoma.
The Impact of Immune Interaction on the Metastatic Infiltration of Colorectal Carcinoma to Lymph Nodes.
Tumor infiltrating lymphocytes: an intriguing player in the survival of colorectal cancer patients.
Communicable Diseases
Impairment of Granzyme B-Producing Regulatory B Cells Correlates with Exacerbated Rheumatoid Arthritis.
Congenital Abnormalities
Phenotypic and functional characterization of natural killer cells in rheumatoid arthritis-regulation with interleukin-15.
Coronary Aneurysm
CD8 T lymphocytes do not express cytotoxic proteins in coronary artery aneurysms in acute Kawasaki disease.
Coronary Artery Disease
Granzyme B as a novel factor involved in cardiovascular diseases.
Plasma granzyme B as a predicting factor of coronary artery disease-Clinical significance in patients with chronic renal failure.
COVID-19
CIGB-258, a peptide derived from human heat-shock protein 60, decreases hyperinflammation in COVID-19 patients.
CXCL10 could drive longer duration of mechanical ventilation during COVID-19 ARDS.
Defining the CD39/CD73 Axis in SARS-CoV-2 Infection: The CD73- Phenotype Identifies Polyfunctional Cytotoxic Lymphocytes.
In vitro Interleukin-7 treatment partially rescues MAIT cell dysfunction caused by SARS-CoV-2 infection.
Inflammation Profiling of Critically Ill Coronavirus Disease 2019 Patients.
Plasma biomarker profiling of PIMS-TS, COVID-19 and SARS-CoV2 seropositive children - a cross-sectional observational study from southern India.
Cowpox
Differential inhibition of the Fas- and granule-mediated cytolysis pathways by the orthopoxvirus cytokine response modifier A/SPI-2 and SPI-1 protein.
Granzyme B is inhibited by the cowpox virus serpin cytokine response modifier A.
Myxoma virus Serp2 is a weak inhibitor of granzyme B and interleukin-1beta-converting enzyme in vitro and unlike CrmA cannot block apoptosis in cowpox virus-infected cells.
Subcellular localization of CrmA: identification of a novel leucine-rich nuclear export signal conserved in anti-apoptotic serpins.
The cytotoxic cell protease granzyme B initiates apoptosis in a cell-free system by proteolytic processing and activation of the ICE/CED-3 family protease, CPP32, via a novel two-step mechanism.
Crohn Disease
Differential levels of granzyme B, regulatory cytokines, and apoptosis in Crohn's disease and ulcerative colitis at first presentation.
Role of IL-1ra and Granzyme B as biomarkers in active Crohn's disease patients.
Cysts
Penetration of CD8+ Cytotoxic T Cells into Large Target, Tissue Cysts of Toxoplasma gondii, Leads to Its Elimination.
Cytomegalovirus Infections
Differential cleavage of viral polypeptides by allotypic variants of granzyme B skews immunity to mouse cytomegalovirus.
Expression of granzyme B during primary cytomegalovirus infection after renal transplantation.
The Critical Role of IL-15-PI3K-mTOR Pathway in Natural Killer Cell Effector Functions.
The granzyme B inhibitor SERPINB9 (protease inhibitor 9) circulates in blood and increases on primary cytomegalovirus infection after renal transplantation.
Dengue
Functionality of dengue virus specific memory T cell responses in individuals who were hospitalized or who had mild or subclinical dengue infection.
Dermatitis
Blockade of granzyme B remarkably improves mucocutaneous diseases with keratinocyte death in interface dermatitis.
Histopathology of drug-induced exanthems: is there a role in diagnosis of drug allergy?
Infiltration of cytotoxic T cells in drug-induced cutaneous eruptions.
Relationships among plasma granzyme B level, pruritus and dermatitis in patients with atopic dermatitis.
Dermatitis, Allergic Contact
A comparative study of the expression of cytotoxic proteins in allergic contact dermatitis and psoriasis: spongiotic skin lesions in allergic contact dermatitis are highly infiltrated by T cells expressing perforin and granzyme B.
Dermatitis, Atopic
Perforin and granzyme B may contribute to skin inflammation in atopic dermatitis and psoriasis.
Relationships among plasma granzyme B level, pruritus and dermatitis in patients with atopic dermatitis.
Dermatitis, Contact
Serum concentrations of metalloproteinase 2, metalloproteinase 9 and granzyme B in contact eczema patients.
The role of CD4 and CD8 cytotoxic T lymphocytes in the formation of viral vesicles.
Dermatomyositis
The Fas/Fas ligand system, rather than granzyme B, may represent the main mediator of epidermal apoptosis in dermatomyositis.
Diabetes Mellitus
The serine protease granzyme B as an inflammatory marker, in relation to the insulin receptor cleavage in human obesity and type 2 diabetes mellitus.
Diabetes Mellitus, Type 1
Correlation of genetic markers of rejection with biopsy findings following human pancreas transplant.
Granzyme B is dispensable in the development of diabetes in non-obese diabetic mice.
Peripheral blood cytotoxic lymphocyte gene transcript levels differ in patients with long-term type 1 diabetes compared to normal controls.
Diabetes Mellitus, Type 2
Increased circulating granzyme B in type 2 diabetes patients with low-grade systemic inflammation.
The serine protease granzyme B as an inflammatory marker, in relation to the insulin receptor cleavage in human obesity and type 2 diabetes mellitus.
Drug Eruptions
Drug-induced exanthems.
Ectromelia
Caspase-dependent inhibition of mousepox replication by gzmB.
Granzymes are the essential downstream effector molecules for the control of primary virus infections by cytolytic leukocytes.
Encephalitis
A substantial number of Rasmussen syndrome patients have increased IgG, CD4(+) T cells, TNFalpha, and Granzyme B in CSF.
Encephalomyelitis, Eastern Equine
Characterisation of immune responses in healthy foals when a multivalent vaccine protocol was initiated at age 90 or 180 days.
Encephalomyelitis, Western Equine
Characterisation of immune responses in healthy foals when a multivalent vaccine protocol was initiated at age 90 or 180 days.
Endometrial Neoplasms
POLE Proofreading Mutations Elicit an Antitumor Immune Response in Endometrial Cancer.
Endometriosis
Granzyme B levels and granzyme B polymorphisms in peripheral blood of patients with endometriosis: a preliminary study.
Eosinophilia
Granulysin-Based Lymphocyte Activation Test for Evaluating Drug Causality in Antiepileptics-Induced Severe Cutaneous Adverse Reactions.
Epstein-Barr Virus Infections
Hepatosplenic gamma-delta T-cell lymphoma associated with Epstein-Barr virus.
Primary Epstein-Barr virus infection does not erode preexisting CD8+ T cell memory in humans.
Erythema Multiforme
Detection of granzyme B in CD3-positive cells infiltrated in lesional skin of a dog with erythema multiforme associated with zonisamide.
Esophageal Achalasia
The nature of the myenteric infiltrate in achalasia: an immunohistochemical analysis.
Exanthema
IKZF1 polymorphisms are associated with susceptibility, cytokine levels, and clinical features in systemic lupus erythematosus.
Infiltration of cytotoxic T cells in drug-induced cutaneous eruptions.
Pathogenesis of drug-induced exanthema.
Fowlpox
Preclinical development of HIvax: Human survivin highly immunogenic vaccines.
Gastritis
High Proportion of Granzyme B+ Intraepithelial Lymphocytes Contributes to Epithelial Apoptosis in Helicobacter pylori-Associated Lymphocytic Gastritis.
Giardiasis
Evidence that intestinal intraepithelial lymphocytes are activated cytotoxic T cells in celiac disease but not in giardiasis.
Glioblastoma
Defective Regulation of Membrane TNF? Expression in Dendritic Cells of Glioblastoma Patients Leads to the Impairment of Cytotoxic Activity against Autologous Tumor Cells.
Differential PARP cleavage: an indication for existence of multiple forms of cell death in human gliomas.
Infiltrating CTLs in human glioblastoma establish immunological synapses with tumorigenic cells.
Potential Role of Thymosin-alpha1 Adjuvant Therapy for Glioblastoma.
T cells expressing NKG2D chimeric antigen receptors efficiently eliminate glioblastoma and cancer stem cells.
Glioma
Brain microenvironment promotes the final functional maturation of tumor-specific effector CD8+ T cells.
Cytotoxic CD4(+) T cells are correlated with better prognosis in Han Chinese grade II and grade III glioma subjects and are suppressed by PD-1 signaling.
Functional Change of Effector Tumor-Infiltrating CCR5+CD38+HLA-DR+CD8+ T Cells in Glioma Microenvironment.
Glioma cell-derived placental growth factor induces regulatory B cells.
Graft vs Host Disease
FK506 inhibits severe graft-versus-host disease without mediating the involvement of perforin and granzyme B.
Genetic variations in T-cell activation and effector pathways modulate alloimmune reactivities after allogeneic hematopoietic stem cell transplantation for patients with hematological malignancies.
Granzyme B is not required for regulatory T cell-mediated suppression of graft-versus-host disease.
Granzyme B-Mediated Activation-Induced Death of CD4+ T Cells Inhibits Murine Acute Graft-versus-Host Disease.
High expression of granzyme B in conventional CD4+ T cells is associated with increased relapses after allogeneic stem cells transplantation in patients with hematological malignancies.
The role of granzyme B cluster proteases in cell-mediated cytotoxicity.
The role of granzyme B in murine models of acute graft-versus-host disease and graft rejection.
[The correlated research of acute graft versus host disease after allogeneic stem cell transplantation]
Granuloma
Immune distribution and localization of phosphoantigen-specific Vgamma2Vdelta2 T cells in lymphoid and nonlymphoid tissues in Mycobacterium tuberculosis infection.
Limited pulmonary mucosal-associated invariant T cell accumulation and activation during Mycobacterium tuberculosis infection in rhesus macaques.
granzyme b deficiency
CD8+ T-cell dysfunction due to cytolytic granule deficiency in persistent Friend retrovirus infection.
Granzyme B deficiency exacerbates lung inflammation in mice after acute lung injury.
Granzyme B deficiency promotes osteoblastic differentiation and calcification of vascular smooth muscle cells in hypoxic pulmonary hypertension.
Granzyme B Deficiency Protects against Angiotensin II-Induced Cardiac Fibrosis.
Perforin and granzyme B have separate and distinct roles during atherosclerotic plaque development in apolipoprotein E knockout mice.
Hand, Foot and Mouth Disease
GATA1/SP1 and miR-874 mediate enterovirus-71-induced apoptosis in a granzyme-B-dependent manner in Jurkat cells.
Hantavirus Infections
Loss of cell membrane integrity in puumala hantavirus-infected patients correlates with levels of epithelial cell apoptosis and perforin.
Head and Neck Neoplasms
Increased PD-1(+) and TIM-3(+) TILs during Cetuximab Therapy Inversely Correlate with Response in Head and Neck Cancer Patients.
Heart Arrest
CTL-Derived Granzyme B Participates in Hippocampal Neuronal Apoptosis Induced by Cardiac Arrest and Resuscitation in Rats.
Hematologic Neoplasms
Genetic variants of human granzyme B predict transplant outcomes after HLA matched unrelated bone marrow transplantation for myeloid malignancies.
High expression of granzyme B in conventional CD4+ T cells is associated with increased relapses after allogeneic stem cells transplantation in patients with hematological malignancies.
[Synergistic Mechanism of Interferon alpha-1b, Interleukin-2 and Thalidomide for Immune Regulation in Patients with Acute Myeloid Leukemia].
Hepatitis
Differential expression of perforin and granzyme B in the liver of patients with chronic hepatitis C.
Expression of Granzyme B in viral hepatitis in patients with ALPS.
Immune-mediated liver injury of the cancer therapeutic antibody catumaxomab targeting EpCAM, CD3 and Fc? receptors.
In situ expression of Granzyme B and Fas-ligand in the liver of viral hepatitis.
Hepatitis B
Myeloid-derived suppressor cells regulate immune response in patients with chronic hepatitis B virus infection through PD-1-induced IL-10.
Hepatitis B, Chronic
In situ expression of Granzyme B and Fas-ligand in the liver of viral hepatitis.
NKG2D modulates aggravation of liver inflammation by activating NK cells in HBV infection.
[Expression characteristics of some immune effector molecules in CD8+ T lymphocytes from patients with chronic hepatitis B]
Hepatitis C, Chronic
CD4(+) /CD25(+) T cells suppress autologous CD4(+) /CD25(-) lymphocytes and secrete granzyme B during acute and chronic hepatitis C.
Differential expression of perforin and granzyme B in the liver of patients with chronic hepatitis C.
Hepatitis, Autoimmune
Perforin and granzyme B lytic protein expression during chronic viral and autoimmune hepatitis.
Hepatitis, Chronic
Perforin and granzyme B lytic protein expression during chronic viral and autoimmune hepatitis.
Herpes Genitalis
Granzyme B cleaves multiple HSV-1 and VZV gene products and VZV ORF4 inhibits Natural Killer cell dependent cytotoxicity.
Herpes Simplex
Kinetics of Primary and Memory Cytotoxic T Lymphocyte Responses to Herpes Simplex Virus 1 Infection: Granzyme B Mediated CTL Activity.
The herpes simplex virus-1 Us3 protein kinase blocks CD8T cell lysis by preventing the cleavage of Bid by granzyme B.
[The mechanism of stimforte action on herpesvirus infection.]
Herpes Zoster
Granzyme B cleaves multiple HSV-1 and VZV gene products and VZV ORF4 inhibits Natural Killer cell dependent cytotoxicity.
Histiocytic Necrotizing Lymphadenitis
Expression of Epstein-Barr virus and granzyme B in cytologic smears of histiocytic necrotizing lymphadenitis.
HIV Infections
Accessory cell dependent NK cell mediated PBMC IFN-gamma production is defective in HIV infection.
Cytotoxic Capacity of SIV-Specific CD8(+) T Cells against Primary Autologous Targets Correlates with Immune Control in SIV-Infected Rhesus Macaques.
Dissociated production of perforin, granzyme B, and IFN-gamma by HIV-specific CD8(+) cells in HIV infection.
Granzyme B as a diagnostic marker of tuberculosis in patients with and without HIV coinfection.
Gut-Associated Plasmacytoid Dendritic Cells Display an Immature Phenotype and Upregulated Granzyme B in Subjects with HIV/AIDS.
Impaired plasmacytoid dendritic cell (PDC)-NK cell activity in viremic human immunodeficiency virus infection attributable to impairments in both PDC and NK cell function.
Tc1 effector diversity shows dissociated expression of granzyme B and interferon-gamma in HIV infection.
Tim-3 negatively regulates cytotoxicity in exhausted CD8+ T cells in HIV infection.
Hodgkin Disease
Expression of the granzyme B inhibitor, protease inhibitor 9, by tumor cells in patients with non-Hodgkin and Hodgkin lymphoma: a novel protective mechanism for tumor cells to circumvent the immune system?
Granzyme B expression in Reed-Sternberg cells of Hodgkin's disease.
Hodgkin disease with subsequent transformation to CD30 positive non-hodgkin lymphoma in six patients.
Prognostic significance of activated cytotoxic T-lymphocytes in primary nodal diffuse large B-cell lymphomas.
Hydatidiform Mole
Age related cellular immune response against complete molar pregnancy.
The granzyme B inhibitor, PI-9, is differentially expressed during placental development and up-regulated in hydatidiform moles.
Hypersensitivity
Boosters of a therapeutic HIV-1 vaccine induce divergent T cell responses related to regulatory mechanisms.
Granzyme B production distinguishes recently activated CD8(+) memory cells from resting memory cells.
Immunity Against Leishmania major Infection: Parasite-Specific Granzyme B Induction as a Correlate of Protection.
Hypertension
Epsin15 Homology Domains: Role in the Pathogenesis of Pulmonary Arterial Hypertension.
Granzyme B deficiency promotes osteoblastic differentiation and calcification of vascular smooth muscle cells in hypoxic pulmonary hypertension.
Intersectin-1s deficiency in pulmonary pathogenesis.
Hypertension, Pulmonary
Granzyme B deficiency promotes osteoblastic differentiation and calcification of vascular smooth muscle cells in hypoxic pulmonary hypertension.
Selective cleavage of nucleolar autoantigen B23 by granzyme B in differentiated vascular smooth muscle cells: insights into the association of specific autoantibodies with distinct disease phenotypes.
Idiopathic Pulmonary Fibrosis
The perforin mediated apoptotic pathway in lung injury and fibrosis.
Infarction, Middle Cerebral Artery
Granzyme-b is involved in mediating post-ischemic neuronal death during focal cerebral ischemia in rat model.
Infections
A pro-survival role for the intracellular granzyme B inhibitor Serpinb9 in natural killer cells during poxvirus infection.
A role for the granzyme B inhibitor serine protease inhibitor 6 in CD8+ memory cell homeostasis.
Activation mechanisms of natural killer cells during influenza virus infection.
Activation-induced T helper cell death contributes to Th1/Th2 polarization following murine Schistosoma japonicum infection.
Adenovirus Serotype 5 Vaccination Results in Suboptimal CD4 T Helper 1 Responses in Mice.
An MHC class Ib-restricted CD8+ T cell response to lymphocytic choriomeningitis virus.
Analysis of the mucosal immune responses induced by single and trickle infections with the bovine abomasal nematode Ostertagia ostertagi.
Antigen-specific clonal expansion and cytolytic effector function of CD8+ T lymphocytes depend on the transcription factor Bcl11b.
Antigenic Re-Stimulation of Virus-Specific Memory CD8+ T Cells Requires Days of Lytic Protein Accumulation for Maximal Cytotoxic Capacity.
Asymptomatic Malaria Infection Is Maintained by a Balanced Pro- and Anti-inflammatory Response.
Blood monitoring of granzyme B and perforin expression after intestinal transplantation: considerations on clinical relevance.
Case report: T-cell responses during clearance of Andes virus from blood cells 2 months after severe hantavirus cardiopulmonary syndrome.
Caspase-dependent inhibition of mousepox replication by gzmB.
CD4(+) /CD25(+) T cells suppress autologous CD4(+) /CD25(-) lymphocytes and secrete granzyme B during acute and chronic hepatitis C.
CD8 T cell effector maturation in HIV-1-infected children.
Central memory CD8+ T cells become CD69+ tissue-residents during viral skin infection independent of CD62L-mediated lymph node surveillance.
Clinical and immunologic predictors of influenza illness among vaccinated older adults.
Collapse of Cytolytic Potential in SIV-Specific CD8+ T Cells Following Acute SIV Infection in Rhesus Macaques.
Complex Interplay Between MAZR and Runx3 Regulates the Generation of Cytotoxic T Lymphocyte and Memory T Cells.
Concomitant detection by flow cytometry of the intragranular antigen granzyme B and the intranuclear antigen Ki-67 in peripheral blood mononuclear cells from healthy individuals and patients with acute CMV infection after renal transplantation.
Connecting Effective Immune Response, Fluorescent Granzyme B-like Peptide, Specific Peptide Binding Patterns, Patients with Cancer and Viral Infection, in Remission, Clinical Significance, and Liquid Biopsy.
Control of lymphocytic choriomeningitis virus infection in granzyme B deficient mice.
Cutting Edge: Enhanced Clonal Burst Size Corrects an Otherwise Defective Memory Response by CD8+ Recent Thymic Emigrants.
Cytomegalovirus (CMV)-Specific Perforin and Granzyme B ELISPOT Assays Detect Reactivation of CMV Infection in Inflammatory Bowel Disease.
Cytotoxic Capacity of SIV-Specific CD8(+) T Cells against Primary Autologous Targets Correlates with Immune Control in SIV-Infected Rhesus Macaques.
Cytotoxic Epstein-Barr virus-positive large B cell lymphoma: a regulatory B cell-derived neoplasia?
Decrease of CD69 levels on TCR V?7.2(+)CD4(+) innate-like lymphocytes is associated with impaired cytotoxic functions in chronic hepatitis B virus-infected patients.
Dendritic cells, macrophages, NK and CD8(+) T lymphocytes play pivotal roles in controlling HSV-1 in the trigeminal ganglia by producing IL1-beta, iNOS and granzyme B.
Depletion but Activation of CD56dimCD16+?NK Cells in Acute Infection with Severe Fever with Thrombocytopenia Syndrome Virus.
Early cytokine and chemokine gene expression in lymph nodes of macaques infected with simian immunodeficiency virus is predictive of disease outcome and vaccine efficacy.
Effect of Broccoli Sprouts and Live Attenuated Influenza Virus on Peripheral Blood Natural Killer Cells: A Randomized, Double-Blind Study.
Elevated levels of serum perforin in chronic HIV-1 and acute SIV/SHIV infection.
Evaluation of cellular immunological responses in mono- and polymorphic clinical forms of Post Kala-Azar Dermal Leishmaniasis in India.
Ex vivo rectal explant model reveals potential opposing roles of Natural Killer cells and Marginal Zone-like B cells in HIV-1 infection.
Frequency, specificity, and sites of expansion of CD8+ T cells during primary pulmonary influenza virus infection.
Functional characterization of MHC class II-restricted CD8+CD4- and CD8-CD4- T cell responses to infection in CD4-/- mice.
Functionality of dengue virus specific memory T cell responses in individuals who were hospitalized or who had mild or subclinical dengue infection.
Genetic variants of human granzyme B predict transplant outcomes after HLA matched unrelated bone marrow transplantation for myeloid malignancies.
Granzyme B as a diagnostic marker of tuberculosis in patients with and without HIV coinfection.
Granzyme B production distinguishes recently activated CD8(+) memory cells from resting memory cells.
Granzyme B regulates antiviral CD8+ T cell responses.
Granzymes are the essential downstream effector molecules for the control of primary virus infections by cytolytic leukocytes.
Hepatitis C virus alternative reading frame protein (ARFP): Production, features, and pathogenesis.
Higher expression of ferritin protects Chlamydia trachomatis infected HeLa 229 cells from reactive oxygen species mediated cell death.
HIV virions and HIV infection in vitro are unaffected by human granzymes A and B.
Host and donor immune responses contribute to antiviral effects of amotosalen-treated donor lymphocytes following early posttransplant cytomegalovirus infection.
IL-6 trans-signaling-dependent rapid development of cytotoxic CD8+ T cell function.
Immune events associated with high level protection against Schistosoma japonicum infection in pigs immunized with UV-attenuated cercariae.
Immunity Against Leishmania major Infection: Parasite-Specific Granzyme B Induction as a Correlate of Protection.
Immunization with Recombinant Adenoviral Vectors Expressing HCV Core or F Proteins Leads to T Cells with Reduced Effector Molecules Granzyme B and IFN-?: A Potential New Strategy for Immune Evasion in HCV Infection.
In vivo identification and characterization of CD4? cytotoxic T cells induced by virulent Brucella abortus infection.
Interleukin-2 and inflammation induce distinct transcriptional programs that promote the differentiation of effector cytolytic T cells.
Kinetics of Primary and Memory Cytotoxic T Lymphocyte Responses to Herpes Simplex Virus 1 Infection: Granzyme B Mediated CTL Activity.
Lipidoid Nanoparticles Containing PD-L1 siRNA Delivered In Vivo Enter Kupffer Cells and Enhance NK and CD8(+) T Cell-mediated Hepatic Antiviral Immunity.
Longevity of T-cell memory following acute viral infection.
MAIT cells contribute to protection against lethal influenza infection in vivo.
Malaria-specific and nonspecific activation of CD8+ T cells during blood stage of Plasmodium berghei infection.
MAVS Deficiency Is Associated With a Reduced T Cell Response Upon Secondary RSV Infection in Mice.
miR-223: infection, inflammation and cancer.
Mucosal-associated invariant and ?? T cell subsets respond to initial Mycobacterium tuberculosis infection.
Murine cytomegalovirus replication in salivary glands is controlled by both perforin and granzymes during acute infection.
Natural killer cells in NOD.NK1.1 mice acquire cytolytic function during viral infection and provide protection against cytomegalovirus.
Perforin and granzyme B of cytotoxic T lymphocyte mediate apoptosis irrespective of Helicobacter pylori infection: possible act as a trigger of peptic ulcer formation.
Properties of CD4(+) T cells in human cytomegalovirus infection.
Quantitating the magnitude of the lymphocytic choriomeningitis virus-specific CD8 T-cell response: it is even bigger than we thought.
Rational Combination of Parvovirus H1 With CTLA-4 and PD-1 Checkpoint Inhibitors Dampens the Tumor Induced Immune Silencing.
Regulatory T cells expressing granzyme B play a critical role in controlling lung inflammation during acute viral infection.
Rhesus Cytomegalovirus-Specific CD8+ Cytotoxic T Lymphocytes Do Not Become Functionally Exhausted in Chronic SIVmac239 Infection.
Role of PD-1 during effector CD8 T cell differentiation.
Stress-induced glucocorticoids at the earliest stages of herpes simplex virus-1 infection suppress subsequent antiviral immunity, implicating impaired dendritic cell function.
Strong impact of CD4+ Foxp3+ regulatory T cells and limited effect of T cell-derived IL-10 on pathogen clearance during Plasmodium yoelii infection.
T cell responses are better correlates of vaccine protection in the elderly.
T regulatory cells contribute to the attenuated primary CD8+ and CD4+ T cell responses to herpes simplex virus type 2 in neonatal mice.
TCR down-regulation boosts T-cell-mediated cytotoxicity and protection against poxvirus infections.
The innate antiviral immune system of the cat: Molecular tools for the measurement of its state of activation.
The unmet need in the elderly: How immunosenescence, CMV infection, co-morbidities and frailty are a challenge for the development of more effective influenza vaccines.
Tissue-resident T cell derived cytokines eliminate herpes simplex virus-2 infected cells.
TLR3 Is a Negative Regulator of Immune Responses Against Paracoccidioides brasiliensis.
Transcriptional profiles in urine during acute rejection, bacteriuria, CMV infection and stable graft function after renal transplantation.
Treatment with native heterodimeric IL-15 increases cytotoxic lymphocytes and reduces SHIV RNA in lymph nodes.
Vaginal chlamydial clearance following primary or secondary infection in mice occurs independently of TNF-?.
Villus epithelial injury induced by infection with the nematode Nippostrongylus brasiliensis is associated with upregulation of granzyme B.
ZIKA virus infection causes persistent chorioretinal lesions.
[Expression characteristics of some immune effector molecules in CD8+ T lymphocytes from patients with chronic hepatitis B]
[Rasmussen encephalitis and non-herpetic acute limbic encephalitis]
Infectious Mononucleosis
B cell-derived circulating granzyme B is a feature of acute infectious mononucleosis.
Inflammatory Bowel Diseases
Cytomegalovirus (CMV)-Specific Perforin and Granzyme B ELISPOT Assays Detect Reactivation of CMV Infection in Inflammatory Bowel Disease.
Differential levels of granzyme B, regulatory cytokines, and apoptosis in Crohn's disease and ulcerative colitis at first presentation.
Plasma cells in the mucosa of patients with inflammatory bowel disease produce granzyme B and possess cytotoxic activities.
Influenza in Birds
Oral administration of an adenovirus vector encoding both an avian influenza A hemagglutinin and a TLR3 ligand induces antigen specific granzyme B and IFN-? T cell responses in humans.
Influenza, Human
A Randomized Controlled Study to Evaluate the Safety and Reactogenicity of a Novel rVLP-Based Plant Virus Nanoparticle Adjuvant Combined with Seasonal Trivalent Influenza Vaccine Following Single Immunization in Healthy Adults 18-50 Years of Age.
Apoptosis of lymphocytes and monocytes infected with influenza virus might be the mechanism of combating virus and causing secondary infection by influenza.
Assessment of markers of the cell-mediated immune response after influenza virus infection in frail older adults.
Cell-Mediated Immune Response to Influenza Using Ex Vivo Stimulation and Assays of Cytokine and Granzyme B Responses.
Cell-mediated immune response to influenza vaccination in lung transplant recipients.
Cellular Interferon Gamma and Granzyme B Responses to Cytomegalovirus-pp65 and Influenza N1 Are Positively Associated in Elderly.
Changes in Cell-Mediated Immunity (IFN-? and Granzyme B) Following Influenza Vaccination.
Characterisation of immune responses in healthy foals when a multivalent vaccine protocol was initiated at age 90 or 180 days.
Clinical and immunologic predictors of influenza illness among vaccinated older adults.
Cytomegalovirus Seropositivity Predicts a Decline in the T Cell But Not the Antibody Response to Influenza in Vaccinated Older Adults Independent of Type 2 Diabetes Status.
Effect of Broccoli Sprouts and Live Attenuated Influenza Virus on Peripheral Blood Natural Killer Cells: A Randomized, Double-Blind Study.
Enhanced influenza A H1N1 T cell epitope recognition and cross-reactivity to protein-O-mannosyltransferase 1 in Pandemrix-associated narcolepsy type 1.
Frequency, specificity, and sites of expansion of CD8+ T cells during primary pulmonary influenza virus infection.
Granzyme B ELISPOT assay to measure influenza-specific cellular immunity.
Granzyme B: a marker of risk for influenza in institutionalized older adults.
Granzyme B: Correlates with protection and enhanced CTL response to influenza vaccination in older adults.
Influenza vaccine-mediated protection in older adults: Impact of influenza infection, cytomegalovirus serostatus and vaccine dosage.
IRES-based co-expression of influenza virus conserved genes can promote synergistic antiviral effects both in vitro and in vivo.
Local blockade of epithelial PDL-1 in the airways enhances T cell function and viral clearance during influenza virus infection.
Lower GrB+ CD62Lhigh CD8 TCM effector lymphocyte response to influenza virus in older adults is associated with increased CD28null CD8 T lymphocytes.
MAIT cells contribute to protection against lethal influenza infection in vivo.
Moderate exercise improves antibody response to influenza immunization in older adults.
Overarching Immunodominance Patterns and Substantial Diversity in Specificity and Functionality in the Circulating Human Influenza A and B Virus-Specific CD4+ T-Cell Repertoire.
Properties of murine (CD8+)CD27- T cells.
T cell responses are better correlates of vaccine protection in the elderly.
The cell-mediated cytotoxic response to influenza vaccination using an assay for granzyme B activity.
The unmet need in the elderly: How immunosenescence, CMV infection, co-morbidities and frailty are a challenge for the development of more effective influenza vaccines.
Keloid
Evaluation of the Role of Granzyme B in Exuberant Scar Pathogenesis: An Immunohistochemical Study.
Keratoacanthoma
A comparative study of granzyme B expression in keratoacanthoma and squamous cell carcinoma.
Possible key role of granzyme B in keratoacanthoma regression.
Kidney Failure, Chronic
Granzyme B as a novel factor involved in cardiovascular diseases.
Plasma granzyme B as a predicting factor of coronary artery disease-Clinical significance in patients with chronic renal failure.
Laryngeal Neoplasms
Co-expression of perforin and granzyme B genes induces apoptosis and inhibits the tumorigenicity of laryngeal cancer cell line Hep-2.
Expression, purification and anticancer analysis of GST-tagged human perforin and granzyme B proteins in human laryngeal cancer Hep-2 cells.
Latent Infection
Granzymes and caspase 3 play important roles in control of gammaherpesvirus latency.
Leishmaniasis, Cutaneous
Analysis of granzyme B activity as a surrogate marker of Leishmania-specific cell-mediated cytotoxicity in zoonotic cutaneous leishmaniasis.
Granzyme B Inhibition by Tofacitinib Blocks the Pathology Induced by CD8 T Cells in Cutaneous Leishmaniasis.
Granzyme B Produced by Natural Killer Cells Enhances Inflammatory Response and Contributes to the Immunopathology of Cutaneous Leishmaniasis.
Leishmaniasis, Visceral
The potential HLA Class I-restricted epitopes derived from LeIF and TSA of Leishmania donovani evoke anti-leishmania CD8+ T lymphocyte response.
Leptospirosis
Release of granzymes and chemokines in Thai patients with leptospirosis.
Leukemia
A cytosolic granzyme B inhibitor related to the viral apoptotic regulator cytokine response modifier A is present in cytotoxic lymphocytes.
Caspase activation by granzyme B is indirect, and caspase autoprocessing requires the release of proapoptotic mitochondrial factors.
Epstein-Barr virus-associated proliferative disorder presenting as Hodgkin's lymphoma and developing as aggressive natural killer-cell leukemia 19 years later: A case report of composite lymphoma.
Ex vivo detection of primary leukemia cells resistant to granule cytotoxin-induced cell death: a rapid isolation method to study granzyme-B-mediated cell death.
Granule serine proteases are normal nuclear constituents of natural killer cells.
hIL-15-gene modified human natural killer cells (NKL-IL15) exhibit anti-human leukemia functions.
Immunotherapy for patients with acute myeloid leukemia using autologous dendritic cells generated from leukemic blasts.
Interaction of perforin and granzyme B and HTLV-1 viral factors is associated with Adult T cell Leukemia development.
LC3B upregulation by NANOG promotes immune resistance and stem-like property through hyperactivation of EGFR signaling in immune-refractory tumor cells.
M860, a Monoclonal Antibody against Human Lactoferrin, Enhances Tumoricidal Activity of Low Dosage Lactoferrin via Granzyme B Induction.
NK cell genotype and phenotype at diagnosis of acute lymphoblastic leukemia correlate with postinduction residual disease.
Polymethoxylated flavones potentiate the cytolytic activity of NK leukemia cell line KHYG-1 via enhanced expression of granzyme B.
Synergistic roles of granzymes A and B in mediating target cell death by rat basophilic leukemia mast cell tumors also expressing cytolysin/perforin.
The granzyme B inhibitor PI-9 is differentially expressed in all main subtypes of pediatric acute lymphoblastic leukemias.
VEGF165b augments NK92 cytolytic activity against human K562 leukemia cells by upregulating the levels of perforin and granzyme B via the VEGR1-PLC pathway.
[Bone marrow-restricted involvement of T-cell granular lymphocyte leukemia]
Leukemia, Lymphocytic, Chronic, B-Cell
CD5(+) B cells from individuals with systemic lupus erythematosus express granzyme B.
Leukemia, Lymphoid
B-chronic lymphocytic leukemia cells and other B cells can produce granzyme B and gain cytotoxic potential after interleukin-21-based activation.
Differentiation of human peripheral blood V{delta}1+ T cells expressing the natural cytotoxicity receptor NKp30 for recognition of lymphoid leukemia cells.
Distinct bone marrow findings in T-cell granular lymphocytic leukemia revealed by paraffin section immunoperoxidase stains for CD8, TIA-1, and granzyme B.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
The receptor for hyaluronic acid-mediated motility induces specific CD8+ T cell response in healthy donors and patients with chronic myeloid leukemia after allogeneic stem cell transplantation.
Leukemia, Myeloid, Acute
Granzyme B induction signalling pathway in acute myeloid leukemia cell lines stimulated by tumor necrosis factor alpha and Fas ligand.
Leukemia, T-Cell
Interaction of perforin and granzyme B and HTLV-1 viral factors is associated with Adult T cell Leukemia development.
Leukemia-Lymphoma, Adult T-Cell
Gastrointestinal T cell lymphoma: predominant cytotoxic phenotypes, including alpha/beta, gamma/delta T cell and natural killer cells.
Leukocytosis
Tumor-infiltrating cells as a prognostic factor in Hodgkin's lymphoma: a quantitative tissue microarray study in a large retrospective cohort of 267 patients.
Lichen Planus
Cytotoxic molecule expression and epithelial cell apoptosis in oral and cutaneous lichen planus.
Involvement of granzyme B and granulysin in the cytotoxic response in lichen planus.
Perforin and granzyme B expression in oral and cutaneous lichen planus - a comparative study.
Perforin and granzyme B involvement in oral lesions of lichen planus and chronic GVHD.
The role of granzyme B-expressing CD8-positive T cells in apoptosis of keratinocytes in lichen planus.
Type 1 interferon signature in the scalp lesions of alopecia areata.
Lichen Planus, Oral
Evaluation of PD-L1, PD-L2, PD-1 and cytotoxic immune response in oral lichen planus.
Perforin and granzyme B involvement in oral lesions of lichen planus and chronic GVHD.
[Expressions of Fas/FasL and granzyme B in oral lichen planus and their significance.]
Lichen Sclerosus et Atrophicus
Detection of perforin and granzyme B mRNA expressing cells in lichen sclerosus.
Liver Cirrhosis
Hepatic local micro-environmental immune status in hepatocellular carcinoma and cirrhotic tissues.
Interferon-?-dependent immune responses contribute to the pathogenesis of sclerosing cholangitis in mice.
Liver Cirrhosis, Biliary
Contribution to antimitochondrial antibody production: cleavage of pyruvate dehydrogenase complex-E2 by apoptosis-related proteases.
Liver Diseases
Enhanced apoptosis relates to bile duct loss in primary biliary cirrhosis.
Lung Injury
Bile Acid aspiration associated with lung chemical profile linked to other biomarkers of injury after lung transplantation.
Lung Neoplasms
A Small Molecule Antagonist of PD-1/PD-L1 Interactions Acts as an Immune Checkpoint Inhibitor for NSCLC and Melanoma Immunotherapy.
Anisamide-Decorated pH-Sensitive Degradable Chimaeric Polymersomes Mediate Potent and Targeted Protein Delivery to Lung Cancer Cells.
Autoimmune response in lung cancer patients with neurological paraneoplastic syndromes.
Frequent T cell responses against immunogenic targets in lung cancer patients for targeted immunotherapy.
Granzyme B is correlated with clinical outcome after PD-1 blockade in patients with stage IV non-small-cell lung cancer.
Increased killer immunoglobulin-like receptor expression and functional defects in natural killer cells in lung cancer.
Increased proteinase inhibitor-9 (PI-9) and reduced granzyme B in lung cancer: Mechanism for immune evasion?
Involvement of granzyme B and perforin in suppressing nodal metastasis of cancer cells in breast and lung cancers.
Lung cancer is associated with decreased expression of perforin, granzyme B and interferon (IFN)-? by infiltrating lung tissue T cells, natural killer (NK)?T-like and NK cells.
Nicotine exhausts CD8+ T cells against tumor cells through increasing miR-629-5p to repress IL2RB-mediated granzyme B expression.
Lupus Erythematosus, Discoid
Immunohistochemical Expression of Granzyme B and Perforin in Discoid Lupus Erythematosus.
Type 1 interferon signature in the scalp lesions of alopecia areata.
Lupus Erythematosus, Systemic
Altered autoantigen structure in Sjögren's syndrome: implications for the pathogenesis of autoimmune tissue damage.
Apoptosis of the teratocarcinoma cell line Tera-1 leads to the cleavage of HERV-K10gag proteins by caspases and/or granzyme B.
CD5(+) B cells from individuals with systemic lupus erythematosus express granzyme B.
Granzyme B is dispensable for immunologic tolerance to self in a murine model of systemic lupus erythematosus.
Increase in activated CD8+ T lymphocytes expressing perforin and granzyme B correlates with disease activity in patients with systemic lupus erythematosus.
Soluble granzyme B and cytotoxic T lymphocyte activity in the pathogenesis of systemic lupus erythematosus.
Systemic and local granzyme B levels are associated with disease activity, kidney damage and interferon signature in systemic lupus erythematosus.
Lupus Nephritis
IL-21 dependent Granzyme B production of B-cells is decreased in patients with lupus nephritis.
Lymphadenitis
Expression of Epstein-Barr virus and granzyme B in cytologic smears of histiocytic necrotizing lymphadenitis.
Lymphatic Metastasis
Absence of Granzyme B positive tumour-infiltrating lymphocytes in primary melanoma excisional biopsies is strongly associated with the presence of sentinel lymph node metastasis.
Correlation of P53 and Granzyme B expression in Oral Squamous Cell Carcinoma with Clinicopathologic Findings.
Lymphocytic Choriomeningitis
A role for the granzyme B inhibitor serine protease inhibitor 6 in CD8+ memory cell homeostasis.
Chronic HIV infection affects the expression of the 2 transcription factors required for CD8 T-cell differentiation into cytolytic effectors.
Control of lymphocytic choriomeningitis virus infection in granzyme B deficient mice.
Cutting edge: Persistently open chromatin at effector gene loci in resting memory CD8+ T cells independent of transcriptional status.
Interleukin-2 and inflammation induce distinct transcriptional programs that promote the differentiation of effector cytolytic T cells.
Lymphocytosis
Idiopathic pure red cell aplasia: first report on CD8 positive lymphocytosis in bone marrow biopsy sections.
Lymphohistiocytosis, Hemophagocytic
Elevated Granzyme B in Cytotoxic Lymphocytes is a Signature of Immune Activation in Hemophagocytic Lymphohistiocytosis.
Sequence analysis of the granulysin and granzyme B genes in familial hemophagocytic lymphohistiocytosis.
[Expression of porforin and granzyme B in familial hemophagocytic lymphohistiocytosis].
Lymphoma
A case of systemic anaplastic large cell lymphoma with 'Hodgkin-like' appearance and skin involvement mimicking lymphomatoid papulosis.
Anaplastic lymphoma kinase-positive anaplastic large cell lymphoma presenting as a bladder neoplasm.
Angiodestruction and tissue necrosis of skin-involving CD56+ NK/T-cell lymphoma are influenced by expression of cell adhesion molecules and cytotoxic granule and apoptosis-related proteins.
B-chronic lymphocytic leukemia cells and other B cells can produce granzyme B and gain cytotoxic potential after interleukin-21-based activation.
Boosting CAR T-cell responses in lymphoma by simultaneous targeting of CD40/4-1BB using oncolytic viral gene therapy.
Cases of cutaneous and nasal CD56 (NCAM)-positive lymphoma in Japan have differences in immunohistology, genotype, and etiology.
CD30 expression in malignant vascular tumors and its diagnostic and clinical implications: a study of 146 cases.
CD30 signals integrate expression of cytotoxic effector molecules, lymphocyte trafficking signals, and signals for proliferation and apoptosis.
Comparative ultrastructural study of cytotoxic granules in nasal natural killer cell lymphoma, intestinal T-cell lymphoma, and anaplastic large cell lymphoma.
Cutaneous intravascular anaplastic large cell lymphoma.
Cutaneous Intravascular NK/T-cell lymphoma mimic panniculitis clinically, case report and literature brief review.
Cytotoxic protein expression in natural killer cell lymphomas and in alpha beta and gamma delta peripheral T-cell lymphomas.
Cytotoxic protein expression in non-Hodgkin's lymphomas and Hodgkin's disease.
Differential expression of cytotoxic molecules and killer cell inhibitory receptors in CD8+ and CD56+ cutaneous lymphomas.
Endogenous IL-21 restricts CD8+ T cell expansion and is not required for tumor immunity.
Epstein-Barr virus in primary gastrointestinal T cell lymphomas. Association with gluten-sensitive enteropathy, pathological features, and immunophenotype.
Epstein-Barr virus-positive T-cell lymphoma cells having chromosome 22q11.2 deletion: an autopsy report of DiGeorge syndrome.
Expression of nm23-H1 is associated with poor prognosis in peripheral T-cell lymphoma.
Expression of the granzyme B inhibitor PI9 predicts outcome in nasal NK/T-cell lymphoma: results of a Western series of 48 patients treated with first-line polychemotherapy within the Groupe d'Etude des Lymphomes de l'Adulte (GELA) trials.
Extranodal NK/T-cell lymphoma, nasal type, arising in association with saline breast implant: expanding the spectrum of breast implant-associated lymphomas.
Genetic variants of human granzyme B predict transplant outcomes after HLA matched unrelated bone marrow transplantation for myeloid malignancies.
Granzyme B immunoreactivity in T/natural killer cell lymphomas.
Granzyme B leakage-induced apoptosis is a crucial mechanism of cell death in nasal-type NK/T-cell lymphoma.
Granzyme B-positive primary gastric T-cell lymphoma: gastric T-cell lymphoma with the possibility of extrathymic T cell origin.
GTPase-activating protein Rasal1 associates with ZAP-70 of the TCR and negatively regulates T-cell tumor immunity.
Hepatosplenic gamma-delta T-cell lymphoma associated with Epstein-Barr virus.
Hepatosplenic gammadelta T-cell lymphoma: ultrastructural, immunophenotypic, and functional evidence for cytotoxic T lymphocyte differentiation.
IL-21 Selectively Protects CD62L+ NKT Cells and Enhances Their Effector Functions for Adoptive Immunotherapy.
Immunophenotypic characteristics and clinical relevance of CD56+ and CD56- extranodal nasal-type natural killer/T-cell lymphoma.
Lymphomas are sensitive to perforin-dependent cytotoxic pathways despite expression of PI-9 and overexpression of bcl-2.
MYD88 L265P mutation promoted malignant B cell resistance against T cell-mediated cytotoxicity via upregulating the IL-10/STAT3 cascade.
Nasal NK/T cell lymphoma presenting as transverse myelopathy.
Neutrophil-rich anaplastic large cell lymphoma presenting in the skin.
Nodal cytotoxic lymphoma spectrum: a clinicopathologic study of 66 patients.
Primary bony peripheral T-cell lymphoma mimicking nasal type NK/T-cell lymphoma: a case report.
Primary central nervous system extranodal nasal-type natural killer/T-cell lymphoma with CD20 expression.
Primary Cutaneous T-Cell Lymphomas Showing Gamma-Delta (??) Phenotype and Predominantly Epidermotropic Pattern are Clinicopathologically Distinct From Classic Primary Cutaneous ?? T-Cell Lymphomas.
Primary extranodal nasal-type natural killer/T-cell lymphoma of the brain: a case report.
Primary gastric apoptosis-rich T-cell lymphoma co-expressing CD4, CD8, and cytotoxic molecules.
Primary gastric natural killer/T-cell lymphoma with diffuse CD30 expression and without CD56 expression: A case report.
Primary hepatic Epstein-Barr virus-associated CD30-positive peripheral T-cell lymphoma of cytotoxic phenotype.
Prognostic significance of activated cytotoxic T-lymphocytes in primary nodal diffuse large B-cell lymphomas.
Sarcomatoid variant of ALK- anaplastic large cell lymphoma involving multiple lymph nodes and both lungs with production of proinflammatory cytokines: report of a case and review of literature.
Superior Therapeutic Index in Lymphoma Therapy: CD30(+) CD34(+) Hematopoietic Stem Cells Resist a Chimeric Antigen Receptor T-cell Attack.
The significance of granzyme B expression in patients with angiocentric lymphoma of the head and neck.
Uniform expression of cytotoxic molecules in anaplastic large cell lymphoma of null/T cell phenotype and in cell lines derived from anaplastic large cell lymphoma.
Updating targets for natural killer/T-cell lymphoma immunotherapy.
[Angioimmunoblastic T-cell lymphoma associated with hemophagocytic syndrome at onset and relapse]
[CD56- and CD4-positive non-Hodgkin's lymphoma of probable T-cell origin]
Lymphoma, B-Cell
Expression of cytotoxic molecules in intestinal T-cell lymphomas. The German Study Group on Intestinal Non-Hodgkin Lymphoma.
Immune mediators in vitreous fluids from patients with vitreoretinal B-cell lymphoma.
Lymphoma, Large-Cell, Anaplastic
Anaplastic lymphoma kinase-positive anaplastic large cell lymphoma presenting as a bladder neoplasm.
CD30 expression in malignant vascular tumors and its diagnostic and clinical implications: a study of 146 cases.
Prognostic significance of activated cytotoxic T-lymphocytes in primary nodal diffuse large B-cell lymphomas.
Lymphoma, Non-Hodgkin
Evaluation of the cytotoxic response mediated by perforin and granzyme B in patients with non-Hodgkin lymphoma.
Genetically re-engineered K562 cells significantly expand and functionally activate cord blood natural killer cells: Potential for adoptive cellular immunotherapy.
Pregnancy-associated cytotoxic lymphoma: a report of 4 cases.
Updating targets for natural killer/T-cell lymphoma immunotherapy.
Lymphoma, T-Cell
Classification of T-cell and NK-cell neoplasms based on the REAL classification.
Comparative ultrastructural study of cytotoxic granules in nasal natural killer cell lymphoma, intestinal T-cell lymphoma, and anaplastic large cell lymphoma.
Expression of cytotoxic molecules in intestinal T-cell lymphomas. The German Study Group on Intestinal Non-Hodgkin Lymphoma.
Granzyme B immunoreactivity in T/natural killer cell lymphomas.
Granzyme B-positive primary gastric T-cell lymphoma: gastric T-cell lymphoma with the possibility of extrathymic T cell origin.
Histopathological features and immunophenotyping of canine transmural gastrointestinal lymphoma using full-thickness biopsy samples.
Most primary cutaneous CD30-positive lymphoproliferative disorders have a CD4-positive cytotoxic T-cell phenotype.
Nodal CD8 positive cytotoxic T-cell lymphoma: a distinct clinicopathological entity.
Peripheral T-cell lymphomas with cytotoxic phenotype in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma.
Lymphoma, T-Cell, Cutaneous
Primary CD30-positive cutaneous T-cell lymphomas and lymphomatoid papulosis frequently express cytotoxic proteins.
Lymphoma, T-Cell, Peripheral
Clinicopathologic and prognostic significance of cytotoxic molecule expression in nodal peripheral T-cell lymphoma, unspecified.
Peripheral T-Cell lymphoma manifested as gingival enlargement in a patient with chronic lymphocytic leukemia.
Lymphomatoid Papulosis
Most primary cutaneous CD30-positive lymphoproliferative disorders have a CD4-positive cytotoxic T-cell phenotype.
Primary CD30-positive cutaneous T-cell lymphomas and lymphomatoid papulosis frequently express cytotoxic proteins.
Lymphoproliferative Disorders
Enhanced tumorigenesis in HTLV-1 tax-transgenic mice deficient in interferon-gamma.
Malaria
Asymptomatic Malaria Infection Is Maintained by a Balanced Pro- and Anti-inflammatory Response.
Cytotoxic T Cell-Derived Granzyme B Is Increased in Severe Plasmodium Falciparum Malaria.
Memory CD73+IgM+ B cells protect against Plasmodium yoelii infection and express Granzyme B.
Soluble markers of neutrophil, T-cell and monocyte activation are associated with disease severity and parasitemia in falciparum malaria.
Malaria, Cerebral
Granzyme B expression by CD8+ T cells is required for the development of experimental cerebral malaria.
Malaria, Falciparum
Cytotoxic T Cell-Derived Granzyme B Is Increased in Severe Plasmodium Falciparum Malaria.
Measles
Measles virus induces apoptosis in uninfected bystander T cells and leads to granzyme B and caspase activation in peripheral blood mononuclear cell cultures.
Melanoma
A Small Molecule Antagonist of PD-1/PD-L1 Interactions Acts as an Immune Checkpoint Inhibitor for NSCLC and Melanoma Immunotherapy.
Absence of Granzyme B positive tumour-infiltrating lymphocytes in primary melanoma excisional biopsies is strongly associated with the presence of sentinel lymph node metastasis.
Activated STAT5 promotes long-lived cytotoxic CD8+ T cells that induce regression of autochthonous melanoma.
Blockade of BAFF Receptor BR3 on T Cells Enhances Their Activation and Cytotoxicity.
Curcumin induces proapoptotic effects against human melanoma cells and modulates the cellular response to immunotherapeutic cytokines.
Cytolytic cells induce HMGB1 release from melanoma cell lines.
Defects in the acquisition of tumor-killing capability of CD8+ cytotoxic T cells in streptozotocin-induced diabetic mice.
Differential Clinicopathological Features in Spontaneous Regression of Melanomas and Melanocytic Naevi.
Differentiation of CD8+ T cells from tumor-invaded and tumor-free lymph nodes of melanoma patients: role of common gamma-chain cytokines.
Distinct patterns of cytolytic T-cell activation by different tumour cells revealed by Ca(2+) signalling and granule mobilization.
Enhanced Cancer Immunotherapy with Smad3-Silenced NK-92 Cells.
Granzyme B Degraded Type IV Collagen Products in Serum Identify Melanoma Patients Responding to Immune Checkpoint Blockade.
Granzyme B PET Imaging as a Predictive Biomarker of Immunotherapy Response.
HCA587 protein vaccine induces specific antitumor immunity mediated by CD4+ T-cells expressing granzyme B in a mouse model of melanoma.
IL-15-induced human DC efficiently prime melanoma-specific naive CD8+ T cells to differentiate into CTL.
Increased expression of perforin and granzyme B genes in patients with metastatic melanoma treated with recombinant interleukin-2.
Inhibitory Effect of Dihydroartemisinin on the Proliferation and Migration of Melanoma Cells and Experimental Lung Metastasis From Melanoma in Mice.
Isolated Limb Perfusion With Melphalan Triggers Immune Activation in Melanoma Patients.
LC3B upregulation by NANOG promotes immune resistance and stem-like property through hyperactivation of EGFR signaling in immune-refractory tumor cells.
Melanoma cell lysosome secretory burst neutralizes the CTL-mediated cytotoxicity at the lytic synapse.
Multiple mechanisms underlie defective recognition of melanoma cells cultured in three-dimensional architectures by antigen-specific cytotoxic T lymphocytes.
Primary Tr1 cells from metastatic melanoma eliminate tumor-promoting macrophages through granzyme B- and perforin-dependent mechanisms.
Targeted Apoptosis Activation with GrB/scFvMEL Modulates Melanoma Growth, Metastatic Spread, Chemosensitivity, and Radiosensitivity.
The decreased susceptibility of metastatic melanoma cells to killing involves an alteration of CTL reactivity.
Upregulation of granzyme B and interferon-? mRNA in responding lesions by treatment with nivolumab for metastatic melanoma: a case report.
Melanoma, Experimental
B16 melanomas evade antitumor immunity by the loss of epitope presentation and the acquisition of tumor resistance to granzyme B.
GTPase-activating protein Rasal1 associates with ZAP-70 of the TCR and negatively regulates T-cell tumor immunity.
Natural Killer Cell Recruitment and Activation Are Regulated by CD47 Expression in the Tumor Microenvironment.
Neem leaf glycoprotein is superior than Cisplatin and Sunitinib malate in restricting melanoma growth by normalization of tumor microenvironment.
Silence STAT3 in the procancer niche… and activate CD8+ T cells to kill premetastatic myeloid intruders.
Meningococcal Infections
Elastase and granzymes during meningococcal disease in children: correlation to disease severity.
Mesothelioma
Foxp3+ Regulatory T Cell Depletion after Nonablative Oligofractionated Irradiation Boosts the Abscopal Effects in Murine Malignant Mesothelioma.
Mouth Diseases
GATA1/SP1 and miR-874 mediate enterovirus-71-induced apoptosis in a granzyme-B-dependent manner in Jurkat cells.
Mucocutaneous Lymph Node Syndrome
Increased Interleukin-35 suppresses peripheral CD14+ monocytes function in patients with Kawasaki disease.
Multiple Myeloma
Accessory Cells of the Microenvironment Protect Multiple Myeloma from T-Cell Cytotoxicity through Cell Adhesion-Mediated Immune Resistance.
CD44-targeted vesicles encapsulating granzyme B as artificial killer cells for potent inhibition of human multiple myeloma in mice.
Expression of granzyme B and perforin in multiple myeloma.
Multiple Sclerosis
A Th17-like developmental process leads to CD8(+) Tc17 cells with reduced cytotoxic activity.
Cleavage of transaldolase by granzyme B causes the loss of enzymatic activity with retention of antigenicity for multiple sclerosis patients.
Nonapoptotic and Extracellular Activity of Granzyme B Mediates Resistance to Regulatory T Cell (Treg) Suppression by HLA-DR-CD25hiCD127lo Tregs in Multiple Sclerosis and in Response to IL-6.
Protease-activated receptor-1 activation by granzyme B causes neurotoxicity that is augmented by interleukin-1?.
Muscular Diseases
[Histological and molecular alterations in inflammatory myopathies].
Myasthenia Gravis
Granzyme B: Evidence for a role in the origin of myasthenia gravis.
Myelodysplastic Syndromes
Analysis of apoptosis regulatory genes expression in the bone marrow (BM) of adult de novo myelodysplastic syndromes (MDS).
Immune mediated autologous cytotoxicity against hematopoietic precursor cells in patients with myelodysplastic syndrome.
Increased TIM3+CD8+T cells in Myelodysplastic Syndrome patients displayed less perforin and granzyme B secretion and higher CD95 expression.
Myocardial Infarction
Cytotoxic CD8+ T cells promote granzyme B-dependent adverse post-ischemic cardiac remodeling.
Elevated levels of granzyme B correlated with miR-874-3p downregulation in patients with acute myocardial infarction.
Elevation of plasma granzyme B levels after acute myocardial infarction.
Granzyme B as a novel factor involved in cardiovascular diseases.
Plasma granzyme B in ST elevation myocardial infarction versus non-ST elevation acute coronary syndrome: comparisons with IL-18 and fractalkine.
Myocarditis
CD4+/CD8+ macrophages infiltrating at inflammatory sites: a population of monocytes/macrophages with a cytotoxic phenotype.
Histopathologic Characterization of Myocarditis Associated With Immune Checkpoint Inhibitor Therapy.
Imaging Granzyme B Activity Assesses Immune-Mediated Myocarditis.
Myositis
Expression of human IAP-like protein in skeletal muscle: a possible explanation for the rare incidence of muscle fiber apoptosis in T-cell mediated inflammatory myopathies.
Polymyositis in solid organ transplant recipients receiving tacrolimus.
Relationship between clinical course of nivolumab-related myositis and immune status in a patient with Hodgkin's lymphoma after allogeneic hematopoietic stem cell transplantation.
The DNA mismatch repair enzyme PMS1 is a myositis-specific autoantigen.
Myositis, Inclusion Body
Expression of human IAP-like protein in skeletal muscle: a possible explanation for the rare incidence of muscle fiber apoptosis in T-cell mediated inflammatory myopathies.
Myxoma
Myxoma virus Serp2 is a weak inhibitor of granzyme B and interleukin-1beta-converting enzyme in vitro and unlike CrmA cannot block apoptosis in cowpox virus-infected cells.
Neoplasm Metastasis
Absence of Granzyme B positive tumour-infiltrating lymphocytes in primary melanoma excisional biopsies is strongly associated with the presence of sentinel lymph node metastasis.
An Oncolytic Adenovirus Targeting Transforming Growth Factor ? Inhibits Protumorigenic Signals and Produces Immune Activation: A Novel Approach to Enhance Anti-PD-1 and Anti-CTLA-4 Therapy.
Antitumor and radiosensitizing synergistic effects of apigenin and cryptotanshinone against solid Ehrlich carcinoma in female mice.
Blockade of A2A receptors potently suppresses the metastasis of CD73+ tumors.
Circulating PD-L1 is associated with T cell infiltration and predicts prognosis in patients with CRLM following hepatic resection.
Combination of immune checkpoint blockade with DNA cancer vaccine induces potent antitumor immunity against P815 mastocytoma.
Correlation of P53 and Granzyme B expression in Oral Squamous Cell Carcinoma with Clinicopathologic Findings.
Encapsulation of a CpG oligonucleotide in cationic liposomes enhances its local antitumor activity following pulmonary delivery in a murine model of metastatic lung cancer.
Experimental supporting data on the influence of platelet-derived factors of malignant pleural effusions on T cell effector functions and their relevance in predicting prognosis of lung adenocarcinoma patients with pleural metastasis.
Granzyme B gene polymorphisms, colorectal cancer risk, and metastasis.
Immunohistochemical investigations on the expression of programmed cell death ligand 1, human leukocyte antigens G and E, and granzyme B in intraoral mucoepidermoid carcinoma.
Involvement of granzyme B and perforin in suppressing nodal metastasis of cancer cells in breast and lung cancers.
Mechanisms involved in IL-15 superagonist enhancement of anti-PD-L1 therapy.
Natural killer cell-mediated ablation of metastatic liver tumors by hydrodynamic injection of IFNalpha gene to mice.
Primary Tumors Limit Metastasis Formation through Induction of IL15-Mediated Cross-Talk between Patrolling Monocytes and NK Cells.
Sequential metastases of colorectal cancer: Immunophenotypes and spatial distributions of infiltrating immune cells in relation to time and treatments.
Silence STAT3 in the procancer niche… and activate CD8+ T cells to kill premetastatic myeloid intruders.
Studies of hormonal regulation, phenotype plasticity, bone metastasis, and experimental therapeutics in androgen-repressed human prostate cancer (ARCaP) model.
Z-100, an Immunomodulatory Extract of Mycobacterium tuberculosis Strain Aoyama B, Prevents Spontaneous Lymphatic Metastasis of B16-BL6 Melanoma.
Z-100, an immunomodulatory extract of Mycobacterium tuberculosis strain Aoyama B, prevents spontaneous lymphatic metastasis of B16-BL6 melanoma.
Neoplasms
18F-FDG PET metabolic-to-morphological volume ratio predicts PD-L1 tumour expression and response to PD-1 blockade in non-small-cell lung cancer.
?-Pinene Enhances the Anticancer Activity of Natural Killer Cells via ERK/AKT Pathway.
A case of systemic anaplastic large cell lymphoma with 'Hodgkin-like' appearance and skin involvement mimicking lymphomatoid papulosis.
A comparison of the local immune status between the primary and metastatic tumor in colorectal cancer: a retrospective study.
A comprehensive analysis of immune infiltration in the tumor microenvironment of osteosarcoma.
A dual-function epidermal growth factor receptor pathway substrate 8 (Eps8)-derived peptide exhibits a potent cytotoxic T lymphocyte-activating effect and a specific inhibitory activity.
A Microfluidic Platform for Single Cell Fluorometric Granzyme B Profiling.
A Negative Feedback Loop Between Autophagy and Immune Responses in Mycobacterium leprae Infection.
A novel expression and purification system for the production of enzymatic and biologically active human granzyme B.
A novel fully-human cytolytic fusion protein based on granzyme B shows in vitro cytotoxicity and ex vivo binding to solid tumors overexpressing the epidermal growth factor receptor.
A novel Granzyme B nanoparticle delivery system simulates immune cell functions for suppression of solid tumors.
A novel nude mice model of human extranodal nasal type NK/T-cell lymphoma.
A novel therapeutic HBV vaccine candidate induces strong polyfunctional cytotoxic T cell responses in mice.
A Novel Vaccine Targeting Glypican-3 as a Treatment for Hepatocellular Carcinoma.
A Possible Role for Perforin and Granzyme B in Resveratrol Enhanced Radiosensitivity of Prostate Cancer.
A substantial number of Rasmussen syndrome patients have increased IgG, CD4(+) T cells, TNFalpha, and Granzyme B in CSF.
A versatile T cell-based assay to assess therapeutic antigen-specific PD-1-targeted approaches.
Absence of CCR2 reduces spontaneous intestinal tumorigenesis in the ApcMin /+ mouse model.
Absence of Granzyme B positive tumour-infiltrating lymphocytes in primary melanoma excisional biopsies is strongly associated with the presence of sentinel lymph node metastasis.
Absence of host NF-?B p50 induces murine glioblastoma tumor regression, increases survival, and decreases T-cell induction of tumor-associated macrophage M2 polarization.
Activated cytotoxic T cells as prognostic marker in Hodgkin's disease.
Activated STAT5 promotes long-lived cytotoxic CD8+ T cells that induce regression of autochthonous melanoma.
Activation of regulatory T cells instigates functional down-regulation of cytotoxic T lymphocytes in human breast cancer.
Adenosine acts through an A3 receptor to prevent the induction of murine anti-CD3-activated killer T cells.
Adenosine receptor 2A blockade increases the efficacy of anti-PD-1 through enhanced anti-tumor T cell responses.
Alogliptin abates memory injuries of hepatic encephalopathy induced by acute paracetamol intoxication via switching-off autophagy-related apoptosis.
Alterations in signal transduction molecules in T lymphocytes from tumor-bearing mice.
Altered CD8+ T-Cell Lymphocyte Function and TC1 Cell Stemness Contribute to Enhanced Malignant Tumor Properties in Murine Models of Sleep Apnea.
An extraordinary T/NK lymphoma, nasal type, occurring primarily in the prostate gland with unusual CD30 positivity: case report and review of the literature.
An Oncolytic Adenovirus Encoding Decorin and Granulocyte Macrophage Colony Stimulating Factor Inhibits Tumor Growth in a Colorectal Tumor Model by Targeting Pro-Tumorigenic Signals and via Immune Activation.
An Oncolytic Adenovirus Targeting Transforming Growth Factor ? Inhibits Protumorigenic Signals and Produces Immune Activation: A Novel Approach to Enhance Anti-PD-1 and Anti-CTLA-4 Therapy.
An ultrastructural study of cutaneous panniculitis-like T-cell lymphoma: cytoplasmic granules and active cellular and cell-to-matrix interaction mimic cytotoxic T-cells.
Anaplastic large cell lymphoma--a rare disorder in southern Taiwan.
Anaplastic large cell lymphomas presented as bone lesions: a clinicopathologic study of six cases and review of the literature.
Andrographolide potentiates PD-1 blockade immunotherapy by inhibiting COX2-mediated PGE2 release.
Anti-leukemia effect of ex vivo expanded DNT cells from AML patients: a potential novel autologous T-cell adoptive immunotherapy.
Antitumor and radiosensitizing synergistic effects of apigenin and cryptotanshinone against solid Ehrlich carcinoma in female mice.
Apoptosis in mycobacterium tuberculosis infection in mice exhibiting varied immunopathology.
Apoptosis pathways as promising targets for skin cancer therapy.
Application of Sodium Selenite in the Prevention and Treatment of Cancers.
Application of the granzyme B ELISPOT assay for monitoring cancer vaccine trials.
Aptamer-T Cell Targeted Therapy for Tumor Treatment Using Sugar Metabolism and Click Chemistry.
Aqueous immune mediators in malignant uveal melanomas in comparison to benign pigmented intraocular tumors.
Assessment of IFN-? and granzyme-B production by in "sitro" technology.
Asymptomatic Malaria Infection Is Maintained by a Balanced Pro- and Anti-inflammatory Response.
B-chronic lymphocytic leukemia cells and other B cells can produce granzyme B and gain cytotoxic potential after interleukin-21-based activation.
B16 melanomas evade antitumor immunity by the loss of epitope presentation and the acquisition of tumor resistance to granzyme B.
B7-H5 blockade enhances CD8+ T-cell-mediated antitumor immunity in colorectal cancer.
B7-H6 as an efficient target for T cell-induced cytotoxicity in haematologic malignant cells.
Bioresponsive functional nanogels as an emerging platform for cancer therapy.
Bispecific anti-PD-1/LAG-3 antibodies for treatment of advanced or metastatic solid tumors: a patent evaluation of US2018326054.
Bispecific Antibody PD-L1 x CD3 Boosts the Anti-Tumor Potency of the Expanded V?2V?2 T Cells.
Blastic natural killer cell lymphoma/leukaemia in a cat.
Blockade of surface-bound TGF-? on regulatory T cells abrogates suppression of effector T cell function in the tumor microenvironment.
Blockade of transforming growth factor ?2 by anti-sense oligonucleotide improves immunotherapeutic potential of IL-2 against melanoma in a humanized mouse model.
Blocking IL-1? reverses the immunosuppression in mouse breast cancer and synergizes with anti-PD-1 for tumor abrogation.
Bortezomib enhances expression of effector molecules in anti-tumor CD8+ T lymphocytes by promoting Notch-nuclear factor-?B crosstalk.
BRAF targeting sensitizes resistant melanoma to cytotoxic T cells.
Bronchiolitis obliterans syndrome is associated with increased senescent lymphocytes in the small airways.
Canine intravascular lymphoma with overt leukemia.
Case Report: Simultaneous Hyperprogression and Fulminant Myocarditis in a Patient With Advanced Melanoma Following Treatment With Immune Checkpoint Inhibitor Therapy.
Catenin Alpha-2 Mutation Changes the Immune Microenvironment in Lung Adenocarcinoma Patients Receiving Immune Checkpoint Inhibitors.
Cbl-b Is Upregulated and Plays a Negative Role in Activated Human NK Cells.
CCL21 and IFN? recruit and activate tumor specific T cells in 3D scaffold model of breast cancer.
CD26-mediated co-stimulation in human CD8(+) T cells provokes effector function via pro-inflammatory cytokine production.
CD3
CD4+ T-Cell Help in the Tumor Milieu Is Required for Recruitment and Cytolytic Function of CD8+ T Lymphocytes.
CD47 in the tumor microenvironment limits cooperation between antitumor T-cell immunity and radiotherapy.
CD4? T cells expressing latency-associated peptide and Foxp3 are an activated subgroup of regulatory T cells enriched in patients with colorectal cancer.
CD8+HLA-DR+ T cells are increased in patients with severe aplastic anemia.
CDK8-Mediated STAT1-S727 Phosphorylation Restrains NK Cell Cytotoxicity and Tumor Surveillance.
Celiac Disease-Related Inflammation Is Marked by Reduction of Nkp44/Nkp46-Double Positive Natural Killer Cells.
Cell surface-bound heat shock protein 70 (Hsp70) mediates perforin-independent apoptosis by specific binding and uptake of granzyme B.
Cell-mediated lysis of autologous platelets in chronic idiopathic thrombocytopenic purpura.
Cellular participation in delayed xenograft rejection of hCD55 transgenic pig hearts by baboons.
Ceria nanoparticles promoted the cytotoxic activity of CD8+ T cells by activating NF-?B signaling.
Characterization of immunoreactivity with whole-slide imaging and digital analysis in high-grade serous ovarian cancer.
Characterization of natural killer and natural killer-like T cells derived from ex vivo expanded and activated cord blood mononuclear cells: implications for adoptive cellular immunotherapy.
Characterization of the ectromelia virus serpin, SPI-2.
Characterization of tumour-infiltrating lymphocytes and apoptosis in colitis-associated neoplasia: comparison with sporadic colorectal cancer.
Chimeric antigen receptor T cells secreting anti-PD-L1 antibodies more effectively regress renal cell carcinoma in a humanized mouse model.
CIGB-258, a peptide derived from human heat-shock protein 60, decreases hyperinflammation in COVID-19 patients.
Clinical and pathological spectrum of CD8-positive cutaneous T-cell lymphomas.
Clinical outcomes and genetic expression profile in human liver graft dysfunction during ischemia/reperfusion injury.
Clinical significance of regulatory T cells and CD8+ effector populations in patients with human endometrial carcinoma.
Co-expression of perforin and granzyme B genes induces apoptosis and inhibits the tumorigenicity of laryngeal cancer cell line Hep-2.
Combination of immune checkpoint blockade with DNA cancer vaccine induces potent antitumor immunity against P815 mastocytoma.
Combined Modality Management of Sinonasal Anaplastic Lymphoma Kinase Negative Anaplastic Large Cell Lymphoma in a Geriatric Patient-Report of a Rare Case.
Comparable polyfunctionality of ectromelia virus- and vaccinia virus-specific murine T cells despite markedly different in vivo replication and pathogenicity.
Comparing high-throughput methods to measure NK cell-mediated antibody dependent cellular cytotoxicity during HIV-infection.
Comparison of six cell penetrating peptides with different properties for in vitro and in vivo delivery of HPV16 E7 antigen in therapeutic vaccines.
Comprehensive analysis of marker gene detection and computed tomography for the diagnosis of human lung cancer.
Connecting Effective Immune Response, Fluorescent Granzyme B-like Peptide, Specific Peptide Binding Patterns, Patients with Cancer and Viral Infection, in Remission, Clinical Significance, and Liquid Biopsy.
Contrasting Prognostic Effects of Tumor-Infiltrating Lymphocyte Density in Cardia and Non-cardia Gastric Adenocarcinomas.
Control of lytic function by mitogen-activated protein kinase/extracellular regulatory kinase 2 (ERK2) in a human natural killer cell line: identification of perforin and granzyme B mobilization by functional ERK2.
Cooperative Immune-Mediated Mechanisms of the HDAC Inhibitor Entinostat, an IL15 Superagonist, and a Cancer Vaccine Effectively Synergize as a Novel Cancer Therapy.
Core2 O-glycan-expressing prostate cancer cells are resistant to NK cell immunity.
Correlation Patterns Among B7 Family Ligands and Tryptophan Degrading Enzymes in Hepatocellular Carcinoma.
CTLA-4 Blockade Expands Infiltrating T Cells and Inhibits Cancer Cell Repopulation during the Intervals of Chemotherapy in Murine Mesothelioma.
Cutaneous adverse drug reaction in patients with epilepsy after acute encephalitis.
Cutaneous Peripheral T-Cell Lymphoma of Cytotoxic Phenotype Mimicking Extranodal NK/T-Cell Lymphoma.
CXCR5(+)CD8(+) T cells infiltrate the colorectal tumors and nearby lymph nodes, and are associated with enhanced IgG response in B cells.
Cytokine and chemokine expression in tumors of mice receiving systemic therapy with IL-12.
Cytotoxic markers and frequency predict functional capacity of natural killer cells infiltrating renal cell carcinoma.
Cytotoxic phenotype of tumor infiltrating lymphocytes in medullary carcinoma of the breast.
Cytotoxic protein expression in natural killer cell lymphomas and in alpha beta and gamma delta peripheral T-cell lymphomas.
Cytotoxic protein expression in non-Hodgkin's lymphomas and Hodgkin's disease.
Cytotoxic T Cells and Granzyme B Associated with Improved Colorectal Cancer Survival in a Prospective Cohort of Older Women.
Cytotoxic T lymphocyte-dependent tumor growth inhibition by a vascular endothelial growth factor-superantigen conjugate.
Defective gammadelta T-cell function and granzyme B gene polymorphism in a cohort of newly diagnosed breast cancer patients.
Defects in the acquisition of tumor-killing capability of CD8+ cytotoxic T cells in streptozotocin-induced diabetic mice.
Defining the CD39/CD73 Axis in SARS-CoV-2 Infection: The CD73- Phenotype Identifies Polyfunctional Cytotoxic Lymphocytes.
Dendritic Cell Vaccination in Metastatic Melanoma Turns "Non-T Cell Inflamed" Into "T-Cell Inflamed" Tumors.
Dendritic cell-based vaccination: powerful resources of immature dendritic cells against pancreatic adenocarcinoma.
Dendritic cells transfected with heat-shock protein 70 messenger RNA for patients with hepatitis C virus-related hepatocellular carcinoma: a phase 1 dose escalation clinical trial.
Design and Discovery of Natural Cyclopeptide Skeleton Based Programmed Death Ligand 1 Inhibitor as Immune Modulator for Cancer Therapy.
Design of Artificial Immunogens Containing Melanoma-associated T-cell Epitopes.
Detection of binding of a synthetic granzyme B-like peptide fluorescent conjugate within platelet-like structures in cancer-related peripheral blood specimens and tissue sections.
Detection of Cancer Cell Death Mediated by a Synthetic Granzyme B-like Peptide Fluorescent Conjugate and the same Peptide Binding in Bacteria.
Development of a human immuno-oncology therapeutic agent targeting HER2: targeted delivery of granzyme B.
Development of Facile and Versatile Platinum Drug Delivering Silicasome Nanocarriers for Efficient Pancreatic Cancer Chemo-Immunotherapy.
Differential Effect of MyD88 Signal in Donor T Cells on Graft-versus-Leukemia Effect and Graft-versus-Host Disease after Experimental Allogeneic Stem Cell Transplantation.
Differential Impact of T-bet and IFN? on Pancreatic Islet Allograft Rejection.
Differential up-regulation of cytosolic and membrane-bound heat shock protein 70 in tumor cells by anti-inflammatory drugs.
Direct Tumor Killing and Immunotherapy through Anti-SerpinB9 Therapy.
Discovery of secondary sulphonamides as IDO1 inhibitors with potent antitumour effects in vivo.
Disparate distribution of 16 candidate single nucleotide polymorphisms among racial and ethnic groups of pediatric heart transplant patients.
Distinct expression of perforin and granzyme B in lip and oral cavity squamous cell carcinoma.
Distinct functions of CXCR3+ and CCR4+CD4+ T-cells accumulated in human tuberculosis pleural fluid.
Distinct patterns of cytolytic T-cell activation by different tumour cells revealed by Ca(2+) signalling and granule mobilization.
DNAX accessory molecule-1 mediated recognition of freshly isolated ovarian carcinoma by resting natural killer cells.
DNAX-activating protein 10 co-stimulation enhances the anti-tumor efficacy of chimeric antigen receptor T cells.
Donor treatment with carbon monoxide can yield islet allograft survival and tolerance.
Early Tumor-Infiltrating Dendritic Cells Change their Characteristics Drastically in Association with Murine Melanoma Progression.
EBAG9 modulates host immune defense against tumor formation and metastasis by regulating cytotoxic activity of T lymphocytes.
Echinococcus multilocularis induces surface high expression of inhibitory killer immunoglobulin-like receptor on natural killer cells.
Effects of Beta-Blockers on Melanoma Microenvironment and Disease Survival in Human.
Effects of Combinations of Goat Milk and Oligosaccharides on Altering the Microbiota, Immune Responses, and Short Chain Fatty Acid Levels in the Small Intestines of Mice.
EGFR and CD44 Dual-Targeted Multifunctional Hyaluronic Acid Nanogels Boost Protein Delivery to Ovarian and Breast Cancers In Vitro and In Vivo.
EGFR-targeted granzyme B expressed in NK cells enhances natural cytotoxicity and mediates specific killing of tumor cells.
Elevated interleukin-27 enhances the polarization of Th1/Tc1 cells and the production of proinflammatory cytokines in primary immune thrombocytopenia.
Elevated serum granulysin and its clinical relevance in mature NK-cell neoplasms.
Elevation of plasma granzyme B levels after acute myocardial infarction.
Endothelial cell apoptosis in severe drug-induced bullous eruptions.
Enhanced Antitumor Response to Immune Checkpoint Blockade Exerted by Cisplatin-Induced Mutagenesis in a Murine Melanoma Model.
Enhanced Cancer Immunotherapy with Smad3-Silenced NK-92 Cells.
Enhancement of immunogenicity of a therapeutic cervical cancer DNA-based vaccine by co-application of sequence-optimized genetic adjuvants.
Enhancing Dendritic Cell-based Immunotherapy with IL-2/Monoclonal Antibody Complexes for Control of Established Tumors.
Enhancing direct cytotoxicity and response to immune checkpoint blockade following ionizing radiation with Wee1 kinase inhibition.
Enteropathy-associated T-cell lymphomas have a cytotoxic T-cell phenotype.
Epirubicin pretreatment enhances NK cell-mediated cytotoxicity against breast cancer cells in vitro.
Epithelium derived interleukin 15 regulates intraepithelial lymphocyte Th1 cytokine production, cytotoxicity, and survival in coeliac disease.
Epstein-Barr virus in primary gastrointestinal T cell lymphomas. Association with gluten-sensitive enteropathy, pathological features, and immunophenotype.
Epstein-Barr virus-associated natural killer/T-cell lymphomas.
Epstein-Barr Virus-Induced Gene 3 (EBI3) Blocking Leads to Induce Antitumor Cytotoxic T Lymphocyte Response and Suppress Tumor Growth in Colorectal Cancer by Bidirectional Reciprocal-Regulation STAT3 Signaling Pathway.
Erratum to: 'Expression of granzyme B sensitizes ALK+ ALCL tumour cells to apoptosis-inducing drugs'.
Etanercept reduces the serum levels of macrophage chemotactic protein-1 in patients with rheumatoid arthritis.
Evaluation of expression of common genes in the intestine and peripheral blood mononuclear cells (PBMC) associated with celiac disease.
Evaluation of serum-free media formulations in feeder cell-stimulated expansion of natural killer cells.
Ex vivo characterization of human CD8+ T subsets with distinct replicative history and partial effector functions.
Ex vivo expansion and Th1/Tc1 maturation of umbilical cord blood T cells by CD3/CD28 costimulation.
Ex Vivo Interleukin-12-Priming During CD8(+) T Cell Activation Dramatically Improves Adoptive T Cell Transfer Antitumor Efficacy in a Lymphodepleted Host.
Ex vivo simulation of leukocyte function: Stimulation of specific subset of leukocytes in whole blood followed by the measurement of function-associated mRNAs.
Examining Immunotherapy Response Using Multiple Radiotracers.
Expression of a Broad Array of Negative Costimulatory Molecules and Blimp-1 in T Cells following Priming by HIV-1 Pulsed Dendritic Cells.
Expression of cellular FLICE inhibitory protein, caspase-8, and protease inhibitor-9 in Ewing sarcoma and implications for susceptibility to cytotoxic pathways.
Expression of cytotoxic molecules in intestinal T-cell lymphomas. The German Study Group on Intestinal Non-Hodgkin Lymphoma.
Expression of endogenous granzyme B in a subset of human primary breast carcinomas.
Expression of FOXP3, CD14, and ARG1 in Neuroblastoma Tumor Tissue from High-Risk Patients Predicts Event-Free and Overall Survival.
Expression of granzyme B sensitizes ALK+ ALCL tumour cells to apoptosis-inducing drugs.
Expression of Leukotriene B4 Receptor-1 on CD8+ T Cells Is Required for Their Migration into Tumors To Elicit Effective Antitumor Immunity.
Expression of MAGE tumour-associated antigens is inversely correlated with tumour differentiation in invasive ductal breast cancers: an immunohistochemical study.
Expression of the apoptosis inhibitor protease inhibitor 9 predicts clinical outcome in vaccinated patients with stage III and IV melanoma.
Expression of the granzyme B inhibitor, protease inhibitor 9, by tumor cells in patients with non-Hodgkin and Hodgkin lymphoma: a novel protective mechanism for tumor cells to circumvent the immune system?
Expression pattern of immune suppressive cytokines and growth factors in oesophageal adenocarcinoma reveal a tumour immune escape-promoting microenvironment.
Expression, purification and anticancer analysis of GST-tagged human perforin and granzyme B proteins in human laryngeal cancer Hep-2 cells.
Extranodal cytotoxic T-cell lymphoma in a patient with X-linked agammaglobulinaemia.
Extranodal nasal-type natural killer/T-cell lymphoma of the skin: a clinicopathologic study of 16 cases in China.
Extranodal natural killer/T-cell lymphoma, nasal-type.
Extranodal NK/T-cell lymphoma in Tunisia: clinicopathological features, immunophenotype and EBV infection.
Extranodal NK/T-cell lymphoma, nasal type of the uterine cervix: A case report.
Factors associated with severe granulomatous pneumonia in Mycobacterium tuberculosis-infected mice vaccinated therapeutically with hsp65 DNA.
Foxp3+ Regulatory T Cell Depletion after Nonablative Oligofractionated Irradiation Boosts the Abscopal Effects in Murine Malignant Mesothelioma.
Frequent T cell responses against immunogenic targets in lung cancer patients for targeted immunotherapy.
Functional activity of natural killer cells in biological fluids in patients with colorectal and ovarian cancers.
Functional CD8+ T cells infiltrate into nonsmall cell lung carcinoma.
Functional Characterization of BK Virus-Specific CD4(+) T Cells with Cytotoxic Potential in Seropositive Adults.
Functional role of phosphatidylinositol 3-kinase in direct tumor lysis by human natural killer cells.
Gadd45b and Gadd45g are important for anti-tumor immune responses.
Gap junction intercellular communications regulate NK cell activation and modulate NK cytotoxic capacity.
Gene expression analysis of tumor infiltrating lymphocyte markers in endometrial cancers indicates no significant increases in those cases with microsatellite instability.
Generation of tumor-specific T lymphocytes using dendritic cell/tumor fusions and anti-CD3/CD28.
Genetic variants of human granzyme B predict transplant outcomes after HLA matched unrelated bone marrow transplantation for myeloid malignancies.
Genetically Induced Tumors in the Oncopig Model Invoke an Antitumor Immune Response Dominated by Cytotoxic CD8?+ T Cells and Differentiated ?? T Cells Alongside a Regulatory Response Mediated by FOXP3+ T Cells and Immunoregulatory Molecules.
GITR ligation enhances functionality of tumor-infiltrating T cells in hepatocellular carcinoma.
Glial injury in neurotoxicity after pediatric CD19-directed chimeric antigen receptor T cell therapy.
Granzyme B and Perforin Are Important for Regulatory T Cell-Mediated Suppression of Tumor Clearance.
Granzyme B and perforin produced by SEC2 mutant-activated human CD4+ T cells and CD8+ T cells induce apoptosis of K562 leukemic cells by the mitochondrial apoptotic pathway.
Granzyme B as a prognostic marker of cervical intraepithelial neoplasia.
Granzyme B Contributes to the Optimal Graft-Versus-Tumor Effect Mediated by Conventional CD4
Granzyme B degradation by autophagy decreases tumor cell susceptibility to natural killer-mediated lysis under hypoxia.
Granzyme B Expression Is Enhanced in Human Monocytes by TLR8 Agonists and Contributes to Antibody-Dependent Cellular Cytotoxicity.
Granzyme B Functionalized Nanoparticles Targeting Membrane Hsp70-Positive Tumors for Multimodal Cancer Theranostics.
Granzyme B gene polymorphisms, colorectal cancer risk, and metastasis.
Granzyme B immunoreactivity in T/natural killer cell lymphomas.
Granzyme B in Inflammatory Diseases: Apoptosis, Inflammation, Extracellular Matrix Remodeling, Epithelial-to-Mesenchymal Transition and Fibrosis.
Granzyme B in peripheral blood mononuclear cells as a measure of cell-mediated immune response in paraneoplastic neurological syndromes and malignancy.
Granzyme B induction signalling pathway in acute myeloid leukemia cell lines stimulated by tumor necrosis factor alpha and Fas ligand.
Granzyme B is expressed in urothelial carcinoma and promotes cancer cell invasion.
Granzyme B leakage-induced apoptosis is a crucial mechanism of cell death in nasal-type NK/T-cell lymphoma.
Granzyme B nanoreporter for early monitoring of tumor response to immunotherapy.
Granzyme B PET Imaging as a Predictive Biomarker of Immunotherapy Response.
Granzyme B PET Imaging of Combined Chemotherapy and Immune Checkpoint Inhibitor Therapy in Colon Cancer.
Granzyme B PET imaging of immune-mediated tumor killing as a tool for understanding immunotherapy response.
Granzyme B Produced by Natural Killer Cells Enhances Inflammatory Response and Contributes to the Immunopathology of Cutaneous Leishmaniasis.
Granzyme B production distinguishes recently activated CD8(+) memory cells from resting memory cells.
Granzyme B proteolyzes receptors important to proliferation and survival, tipping the balance toward apoptosis.
Granzyme B triggers a prolonged pressure to die in Bcl-2 overexpressing cells, defining a window of opportunity for effective treatment with ABT-737.
Granzyme B-activated p53 interacts with Bcl-2 to promote cytotoxic lymphocyte-mediated apoptosis.
Granzyme B-expressing treg cells are enriched in colorectal cancer and present the potential to eliminate autologous T conventional cells.
Granzyme B-induced cell death.
Granzyme B-loaded, cell-selective penetrating and reduction-responsive polymersomes effectively inhibit progression of orthotopic human lung tumor in vivo.
Granzyme B-mediated apoptosis proceeds predominantly through a Bcl-2-inhibitable mitochondrial pathway.
Granzyme B-mediated damage of CD8+ T cells impairs graft-versus-tumor effect.
Granzyme B-positive primary gastric T-cell lymphoma: gastric T-cell lymphoma with the possibility of extrathymic T cell origin.
Granzyme B: a natural born killer.
Granzyme B: pro-apoptotic, antiviral and antitumor functions.
Granzyme M as a novel effector molecule for human cytolytic fusion proteins: CD64-specific cytotoxicity of Gm-H22(scFv) against leukemic cells.
Granzyme M targets topoisomerase II alpha to trigger cell cycle arrest and caspase-dependent apoptosis.
GTPase-activating protein Rasal1 associates with ZAP-70 of the TCR and negatively regulates T-cell tumor immunity.
Hax-1: a regulator of calcium signaling and apoptosis progression with multiple roles in human disease.
HBV-specific CD4+ cytotoxic T cells in hepatocellular carcinoma are less cytolytic toward tumor cells and suppress CD8+ T cell-mediated antitumor immunity.
HCA587 protein vaccine induces specific antitumor immunity mediated by CD4+ T-cells expressing granzyme B in a mouse model of melanoma.
Heat shock protein 70 surface-positive tumor exosomes stimulate migratory and cytolytic activity of natural killer cells.
Hepatic expression of IL-15 mRNA is associated with liver graft acceptance.
HER2-targeting recombinant protein with truncated pseudomonas exotoxin A translocation domain efficiently kills breast cancer cells.
Heteroclitic XBP1 peptides evoke tumor-specific memory cytotoxic T lymphocytes against breast cancer, colon cancer, and pancreatic cancer cells.
High levels of granzyme B expression in invasive cervical carcinoma correlates to poor response to treatment.
High numbers of granzyme B/CD8-positive tumour-infiltrating lymphocytes in nasopharyngeal carcinoma biopsies predict rapid fatal outcome in patients treated with curative intent.
High prevalence of activated intraepithelial cytotoxic T lymphocytes and increased neoplastic cell apoptosis in colorectal carcinomas with microsatellite instability.
High prevalence of Foxp3 and IL17 in MMR-proficient colorectal carcinomas.
High-affinity T cell receptors redirect cytokine-activated T cells (CAT) to kill cancer cells.
High-dose cyclophosphamide induces specific tumor immunity with concomitant recruitment of LAMP1/CD107a-expressing CD4-positive T cells into tumor sites.
High-dose IL-2/CD25 fusion protein amplifies vaccine-induced CD4+ and CD8+ neoantigen-specific T cells to promote antitumor immunity.
Highly Multiplexed Proteomic Analysis of Quantiferon Supernatants To Identify Biomarkers of Latent Tuberculosis Infection.
hSMG-1 is a granzyme B-associated stress-responsive protein kinase.
Human and mouse granzyme M display divergent and species-specific substrate specificities.
Human Asymptomatic Epitopes Identified from the Herpes Simplex Virus Tegument Protein VP13/14 (UL47) Preferentially Recall Polyfunctional Effector Memory CD44high CD62Llow CD8+ TEM Cells and Protect Humanized HLA-A*02:01 Transgenic Mice against Ocular Herpesvirus Infection.
Human CD8(+) T cells transduced with an additional receptor bispecific for both Mycobacterium tuberculosis and HIV-1 recognize both epitopes.
Human papilloma virus vaccination induces strong human papilloma virus specific cell-mediated immune responses in HIV-infected adolescents and young adults.
Human small intestinal mucosa harbours a small population of cytolytically active CD8+ alphabeta T lymphocytes.
Human TH9 cells are skin-tropic and have autocrine and paracrine proinflammatory capacity.
Hypopigmented Interface T-Cell Dyscrasia and Hypopigmented Mycosis Fungoides: A Comparative Study.
Hypoxia Selectively Impairs CAR-T Cells In Vitro.
Hypoxia Supports Differentiation of Terminally Exhausted CD8 T Cells.
Identification of cytotoxic T-lymphocyte epitope(s) and its agonist epitope(s) of a novel target for vaccine therapy (PAGE4).
Identification of mRNAs expressed in tumor-infiltrating lymphocytes by a strategy for rapid and high throughput screening.
Identification of the BCL2/adenovirus E1B-19K protein-interacting protein 2 (BNIP-2) as a granzyme B target during human natural killer cell-mediated killing.
IFN-? mediates graft-versus-breast cancer effects via enhancing cytotoxic T lymphocyte activity.
IFNalpha2b stimulated release of IFNgamma differentially regulates T cell and NK cell mediated tumor cell cytotoxicity.
IL-15 induces antigen-independent expansion and differentiation of human naive CD8+ T cells in vitro.
IL-15 mimics T cell receptor crosslinking in the induction of cellular proliferation, gene expression, and cytotoxicity in CD8+ memory T cells.
IL-17-producing innate lymphoid cells are restricted to mucosal tissues and are depleted in SIV-infected macaques.
IL-17/IFN-? double producing CD8+ T (Tc17/IFN-?) cells: a novel cytotoxic T-cell subset converted from Tc17 cells by IL-12.
IL-17A Promotes Immune Cell Recruitment in Human Esophageal Cancers and the Infiltrating Dendritic Cells Represent a Positive Prognostic Marker for Patient Survival.
IL-27 enhances IL-15/IL-18-mediated activation of human natural killer cells.
Imaging for Response Assessment in Cancer Clinical Trials.
Imbalance Between Soluble and Membrane-Bound CD100 Regulates Monocytes Activity in Hepatitis B Virus-Associated Acute-on-Chronic Liver Failure.
ImmTAC/Anti-PD-1 antibody combination to enhance killing of cancer cells by reversing regulatory T-cell-mediated immunosuppression.
Immune activation underlies a sustained clinical response to Yttrium-90 radioembolisation in hepatocellular carcinoma.
Immune cell constitution in the tumor microenvironment predicts the outcome in diffuse large B-cell lymphoma.
Immune Escape Mechanism is Impaired in the Microenvironment of Thyroid Lymph Node Metastasis.
Immune infiltration of spontaneous mouse astrocytomas is dominated by immunosuppressive cells from early stages of tumor development.
Immune markers measured before treatment predict outcome of intensive phase tuberculosis therapy.
Immune parameters as markers of tuberculosis extent of disease and early prediction of anti-tuberculosis chemotherapy response.
Immune Responses Raised in an Experimental Colon Carcinoma Model Following Oral Administration of Lactobacillus casei.
Immune responses to a class II helper peptide epitope in patients with stage III/IV resected melanoma.
Immune-activation gene expression in clinically stable renal allograft biopsies: molecular evidence for subclinical rejection.
Immunohistochemical and genetic analysis of Chinese nasal natural killer/T-cell lymphomas.
Immunohistochemical expression of granzyme B and vascular endothelial growth factor (VEGF) in normal uterine cervices and low and high grade squamous intraepithelial lesions.
Immunohistochemical investigations on the expression of programmed cell death ligand 1, human leukocyte antigens G and E, and granzyme B in intraoral mucoepidermoid carcinoma.
Immunological analysis of phase II glioblastoma dendritic cell vaccine (Audencel) trial: immune system characteristics influence outcome and Audencel up-regulates Th1-related immunovariables.
Immunological protection against HPV16 E7-expressing human esophageal cancer cell challenge by a novel HPV16-E6/E7 fusion protein based-vaccine in a Hu-PBL-SCID mouse model.
Immunophenotype of lymphocytic infiltration in medullary carcinoma of the breast.
Immunophenotypes Based on the Tumor Immune Microenvironment Allow for Unsupervised Penile Cancer Patient Stratification.
Immunostimulating and Antimetastatic Effects of Polysaccharides Purified from Ginseng Berry.
Immunosuppressive tumor microenvironment in occupational cholangiocarcinoma: Supportive evidence for the efficacy of immune checkpoint inhibitor therapy.
Immunotherapeutic targeting of membrane hsp70-expressing tumors using recombinant human granzyme B.
Impaired tumor necrosis factor-? secretion by CD4 T cells during respiratory syncytial virus bronchiolitis associated with recurrent wheeze.
Impairment of Granzyme B-Producing Regulatory B Cells Correlates with Exacerbated Rheumatoid Arthritis.
Improved cytotoxic T-lymphocyte immune responses to a tumor antigen by vaccines co-expressing the SLAM-associated adaptor EAT-2.
Improving the in vivo persistence, distribution and function of cytotoxic T lymphocytes by inhibiting the tumor immunosuppressive microenvironment.
Increased antitumor activities of glypican-3-specific chimeric antigen receptor-modified T cells by coexpression of a soluble PD1-CH3 fusion protein.
Increased expression of Apaf-1 and procaspase-3 and the functionality of intrinsic apoptosis apparatus in non-small cell lung carcinoma.
Increased expression of perforin and granzyme B genes in patients with metastatic melanoma treated with recombinant interleukin-2.
Increased frequency of Foxp3+ regulatory T cells in mice with hepatocellular carcinoma.
Increased Interleukin-35 suppresses peripheral CD14+ monocytes function in patients with Kawasaki disease.
Increased natural killer T-like cells are a major source of pro-inflammatory cytokines and granzymes in lung transplant recipients.
Increased Number of Circulating CD8/CD26 T Cells in the Blood of Duchenne Muscular Dystrophy Patients Is Associated with Augmented Binding of Adenosine Deaminase and Higher Muscular Strength Scores.
Increased proteinase inhibitor-9 (PI-9) and reduced granzyme B in lung cancer: Mechanism for immune evasion?
Increased tumor-infiltrating CD45RA(-)CCR7(-) regulatory T-cell subset with immunosuppressive properties foster gastric cancer progress.
Indolent peripheral T-cell lymphoma involving the gastrointestinal tract.
Inducible MyD88/CD40 synergizes with IL-15 to enhance antitumor efficacy of CAR-NK cells.
Induction of CD4(+) and CD8(+) anti-tumor effector T cell responses by bacteria mediated tumor therapy.
Induction of granzyme B expression in T-cell receptor/CD28-stimulated human regulatory T cells is suppressed by inhibitors of the PI3K-mTOR pathway.
Infiltrating CTLs in human glioblastoma establish immunological synapses with tumorigenic cells.
Inflammation Profiling of Critically Ill Coronavirus Disease 2019 Patients.
Inflammatory Gene Expression Profile and Defective Interferon-? and Granzyme K in Natural Killer Cells From Systemic Juvenile Idiopathic Arthritis Patients.
Inhibition of DNA-PK with AZD7648 Sensitizes Tumor Cells to Radiotherapy and Induces Type I IFN-Dependent Durable Tumor Control.
Inhibition of galectin-3 augments the antitumor efficacy of PD-L1 blockade in non-small-cell lung cancer.
Inhibition of NLRP3 inflammasome activation in myeloid-derived suppressor cells by andrographolide sulfonate contributes to 5-FU sensitization in mice.
Inhibition of WEE1 kinase and cell cycle checkpoint activation sensitizes head and neck cancers to natural killer cell therapies.
Integrin ?v?8 on T cells suppresses anti-tumor immunity in multiple models and is a promising target for tumor immunotherapy.
Integrin alphavbeta6 promotes tumor tolerance in colorectal cancer.
Interaction between tumour-infiltrating B cells and T cells controls the progression of hepatocellular carcinoma.
Interaction Networks Converging on Immunosuppressive Roles of Granzyme B: Special Niches Within the Tumor Microenvironment.
Interferon-Gamma Receptor Signaling Plays an Important Role in Restraining Murine Ovarian Tumor Progression.
Interleukin 10 enhanced CD8+ T cell activity and reduced CD8(+) T cell apoptosis in patients with diffuse large B cell lymphoma.
Interleukin 21-induced granzyme B-expressing B cells infiltrate tumors and regulate T cells.
Interleukin-10 production by tumor infiltrating macrophages plays a role in Human Papillomavirus 16 tumor growth.
Interleukin-15-induced CD56(+) myeloid dendritic cells combine potent tumor antigen presentation with direct tumoricidal potential.
Interleukin-35 suppresses antitumor activity of circulating CD8+ T cells in osteosarcoma patients.
Interleukin-9-secreting CD4+ T cells regulate CD8+ T cells cytotoxicity in patients with acute coronary syndromes.
Interruption of MDM2 signaling augments MDM2-targeted T cell-based antitumor immunotherapy through antigen-presenting machinery.
Intraepithelial lymphocytes in normal human intestine do not express proteins associated with cytolytic function.
Intrahepatic lymphocyte expression of dipeptidyl peptidase I-processed granzyme B and perforin induces hepatocyte expression of serine proteinase inhibitor 6 (Serpinb9/SPI-6).
Intratumoral CD103+CD4+ T cell infiltration defines immunoevasive contexture and poor clinical outcomes in gastric cancer patients.
Intratumoral plasmacytoid dendritic cells as a poor prognostic factor for hepatocellular carcinoma following curative resection.
Involvement of granzyme B and perforin in suppressing nodal metastasis of cancer cells in breast and lung cancers.
In Vivo Tumorigenesis, Osteolytic Sarcomas, and Tumorigenic Cell Lines from Transgenic Mice Expressing the Human T-Lymphotropic Virus Type 1 (HTLV-1) Tax Viral Oncogene.
Kctd9 Deficiency Impairs Natural Killer Cell Development and Effector Function.
L-Arginine supplementation inhibits the growth of breast cancer by enhancing innate and adaptive immune responses mediated by suppression of MDSCs in vivo.
Lack of terminally differentiated tumor-specific CD8+ T cells at tumor site in spite of antitumor immunity to self-antigens in human metastatic melanoma.
LC3B upregulation by NANOG promotes immune resistance and stem-like property through hyperactivation of EGFR signaling in immune-refractory tumor cells.
Lenalidomide in an in vitro Dendritic Cell Model for Malignant Gliomas.
Leucine rich repeats and calponin homology domain containing 1 inhibits NK-92 cell cytotoxicity through attenuating Src signaling.
Liposomal Delivery of Mitoxantrone and a Cholesteryl Indoximod Prodrug Provides Effective Chemo-immunotherapy in Multiple Solid Tumors.
Loss of STAT3 in murine NK cells enhances NK cell-dependent tumor surveillance.
Lung cancer is associated with decreased expression of perforin, granzyme B and interferon (IFN)-? by infiltrating lung tissue T cells, natural killer (NK)?T-like and NK cells.
Lymphocyte activation gene 3 negatively regulates the function of intrahepatic hepatitis C virus-specific CD8+ T cells.
Lymphocytic bronchiolitis is associated with inadequate suppression of blood T-cell granzyme B, IFN-gamma, and TNF-alpha.
Mast cells decrease efficacy of anti-angiogenic therapy by secreting matrix-degrading granzyme B.
Mitomycin C enhanced the efficacy of PD-L1 blockade in non-small cell lung cancer.
Modulation of the Tumor Cell Phenotype by IFN-{gamma} Results in Resistance of Uveal Melanoma Cells to Granule-Mediated Lysis by Cytotoxic Lymphocytes.
Monoclonal anti-CD8 therapy induces disease amelioration in the K/BxN mouse model of spontaneous chronic polyarthritis.
Mouse CD8+NKT-like cells exert dual cytotoxicity against mouse tumor cells and myeloid-derived suppressor cells.
Mouse Cytotoxic T Cell-derived Granzyme B Activates the Mitochondrial Cell Death Pathway in a Bim-dependent Fashion.
Multiple molecular and cellular changes associated with tumour stasis and regression during IL-12 therapy of a murine breast cancer model.
Multiplex Cytokine Profiling Identifies Interleukin-27 as a Novel Biomarker for Neonatal Early Onset Sepsis.
Mutations to bid cleavage sites protect hepatocytes from apoptosis after ischemia/reperfusion injury.
Mycobacteria activate ?? T-cell anti-tumour responses via cytokines from type 1 myeloid dendritic cells: a mechanism of action for cancer immunotherapy.
Nasal natural killer/T cell lymphoma with cutaneous involvement: case report and Chinese literature review reported in China mainland.
Nasal vaccination stimulates CD8(+) T cells for potent protection against mucosal Brucella melitensis challenge.
Nasal-type extranodal natural killer/T-cell lymphoma presenting with extensive leg ulcers.
Natural killer cell-mediated ablation of metastatic liver tumors by hydrodynamic injection of IFNalpha gene to mice.
Natural killer cells induce distinct modes of cancer cell death: Discrimination, quantification, and modulation of apoptosis, necrosis, and mixed forms.
Natural killer cells limit cardiac inflammation and fibrosis by halting eosinophil infiltration.
Natural killer cells promote tissue injury and systemic inflammatory responses during fatal Ehrlichia-induced toxic shock-like syndrome.
Near-Infrared Fluorescent Macromolecular Reporters for Real-Time Imaging and Urinalysis of Cancer Immunotherapy.
Neoplasms derived from plasmacytoid monocytes/interferon-producing cells: variability of CD56 and granzyme B expression.
Niclosamide, an antihelmintic drug, enhances efficacy of PD-1/PD-L1 immune checkpoint blockade in non-small cell lung cancer.
Nicotine exhausts CD8+ T cells against tumor cells through increasing miR-629-5p to repress IL2RB-mediated granzyme B expression.
Nintedanib promotes antitumour immunity and shows antitumour activity in combination with PD-1 blockade in mice: potential role of cancer-associated fibroblasts.
NK cells dysfunction in systemic lupus erythematosus: relation to disease activity.
NK cells switch from granzyme B to death receptor-mediated cytotoxicity during serial killing.
Nodal CD8 positive cytotoxic T-cell lymphoma: a distinct clinicopathological entity.
Nodal cytotoxic lymphoma spectrum: a clinicopathologic study of 66 patients.
Non-Malignant CD30+ Cells in Contralateral Peri-Implant Capsule of Patient With BIA-ALCL: A Premalignant Step?
Non-redundant activity of GSK-3? and GSK-3? in T cell-mediated tumor rejection.
Non-replicating Newcastle Disease Virus as an adjuvant for DNA vaccine enhances antitumor efficacy through the induction of TRAIL and granzyme B expression.
Nonimmediate allergic reactions induced by drugs: pathogenesis and diagnostic tests.
Normal regulatory alpha/beta T cells effectively eliminate abnormally activated T cells lacking the interleukin 2 receptor beta in vivo.
NPM-ALK and the JunB transcription factor regulate the expression of cytotoxic molecules in ALK-positive, anaplastic large cell lymphoma.
Nuclear factor-?B1 controls the functional maturation of dendritic cells and prevents the activation of autoreactive T cells.
Nuclear transport of granzyme B (fragmentin-2). Dependence of perforin in vivo and cytosolic factors in vitro.
Nucleofection of non-B cells with mini-Epstein-Barr virus DNA.
Oncolytic Vaccinia Virus Gene Modification and Cytokine Expression Effects on Tumor Infection, Immune Response, and Killing.
Optimization of an elispot assay to detect cytomegalovirus-specific CD8+ T lymphocytes.
p50 suppresses cytotoxic T lymphocyte effector function to regulate tumor immune escape and response to immunotherapy.
PD-1 Expression and Function of T-Cell Subsets in TILs From Human Lung Cancer.
PD-1 Immune Checkpoint Blockade Promotes Therapeutic Cancer Vaccine to Eradicate Lung Cancer.
PD1-CD28 Fusion Protein Enables CD4+ T Cell Help for Adoptive T Cell Therapy in Models of Pancreatic Cancer and Non-hodgkin Lymphoma.
Percentage of activated cytotoxic T-lymphocytes in anaplastic large cell lymphoma and Hodgkin's disease: an independent biological prognostic marker.
Perforin and Granzyme B Expressed by Murine Myeloid-Derived Suppressor Cells: A Study on Their Role in Outgrowth of Cancer Cells.
Perforin and granzyme expression in cytotoxic T-cell lymphomas.
Peripheral T-cell lymphoma arising from an intraglandular lymph node in the parotid gland: a case report and literature review.
Peroxisome proliferator-activated receptor alpha deficiency impairs regulatory T cell functions: Possible application in the inhibition of melanoma tumor growth in mice.
Plasmodium infection inhibits the expansion and activation of MDSCs and Tregs in the tumor microenvironment in a murine Lewis lung cancer model.
Poor clinical outcomes and immunoevasive contexture in interleukin-9 abundant muscle-invasive bladder cancer.
Porphyromonas gingivalis Placental Atopobiosis and Inflammatory Responses in Women With Adverse Pregnancy Outcomes.
Possible key role of granzyme B in keratoacanthoma regression.
Potential Role of Pleural Fluid Cytokine Profile in Myelomatous Pleural Effusions.
Potentiation of a tumor cell susceptibility to autologous CTL killing by restoration of wild-type p53 function.
Primary bony peripheral T-cell lymphoma mimicking nasal type NK/T-cell lymphoma: a case report.
Primary CD56+ NK/T-cell lymphoma of the rectum accompanied with refractory ulcerative colitis.
Primary central nervous system extranodal NK/T cell lymphoma, nasal type, with antecedent hemophagocytic syndrome in a child.
Primary central nervous system extranodal NK/T-cell lymphoma, nasal type: case report and review of the literature.
Primary extranodal natural Killer/T-cell lymphoma in a child in the colon: A case report.
Primary gastric natural killer/T-cell lymphoma with diffuse CD30 expression and without CD56 expression: A case report.
Primary intestinal gamma-delta T-cell lymphoma with evidence of Epstein-Barr virus.
Primary laryngeal NK/T-cell non-Hodgkin lymphoma: A case report.
Primary mucosal CD30-positive T-cell lymphoproliferative disorders of the head and neck rarely involving epiglottis: clinicopathological, immunohistomchemical and genetic features of a case.
Primary rare anaplastic large cell lymphoma, ALK positive in small intestine: case report and review of the literature.
Primary Tr1 cells from metastatic melanoma eliminate tumor-promoting macrophages through granzyme B- and perforin-dependent mechanisms.
Primary Tumors Limit Metastasis Formation through Induction of IL15-Mediated Cross-Talk between Patrolling Monocytes and NK Cells.
PRMT5 disruption drives antitumor immunity in cervical cancer by reprogramming T cell-mediated response and regulating PD-L1 expression.
Psoriasis confined strictly to vitiligo areas - a Koebner-like phenomenon?
Radiation-enhanced delivery of systemically administered amphiphilic-CpG oligodeoxynucleotide.
Radiotherapy increases the permissiveness of established mammary tumors to rejection by immunomodulatory antibodies.
Rapid reuptake of granzyme B leads to emperitosis: an apoptotic cell-in-cell death of immune killer cells inside tumor cells.
Rapid turnover of the CD8(+)CD28(-) T-cell subset of effector cells in the circulation of patients with head and neck cancer.
Rat CD4+CD8+ Macrophages Kill Tumor Cells through an NKG2D- and Granzyme/Perforin-Dependent Mechanism.
Rational combination of oncolytic vaccinia virus and PD-L1 blockade works synergistically to enhance therapeutic efficacy.
Recipient leukocyte infusion enhances the local and systemic graft-versus-neuroblastoma effect of allogeneic bone marrow transplantation in mice.
Regulation of CD28 expression on umbilical cord blood and adult peripheral blood CD8(+) T cells by interleukin(IL)-15/IL-21.
Regulatory effect of Ganoderma lucidum polysaccharides on cytotoxic T-lymphocytes induced by dendritic cells in vitro.
Regulatory T Cells Restrain Interleukin-2- and Blimp-1-Dependent Acquisition of Cytotoxic Function by CD4+ T Cells.
Regulatory T cells specifically suppress conventional CD8?? T cells in intestinal tumors of APCMin/+ mice.
Relationship between clinical course of nivolumab-related myositis and immune status in a patient with Hodgkin's lymphoma after allogeneic hematopoietic stem cell transplantation.
Resistance of cancers to immunologic cytotoxicity and adoptive immunotherapy via X-linked inhibitor of apoptosis protein expression and coexisting defects in mitochondrial death signaling.
Restraint and Social Isolation Stressors Differentially Regulate Adaptive Immunity and Tumor Angiogenesis in a Breast Cancer Mouse Model.
Robust hepatitis B vaccine-reactive T cell responses in failed humoral immunity.
Role of Tumor Necrosis Factor-? and Natural Killer Cells in Uterine Artery Function and Pregnancy Outcome in the Stroke-Prone Spontaneously Hypertensive Rat.
Sarcomatoid variant of ALK- anaplastic large cell lymphoma involving multiple lymph nodes and both lungs with production of proinflammatory cytokines: report of a case and review of literature.
Selective recruitment of ?? T cells by a bispecific antibody for the treatment of acute myeloid leukemia.
Serglycin--structure and biology.
Serous effusion cytology of extranodal natural killer/T-cell lymphoma.
Serpins prevent granzyme-induced death in a species-specific manner.
SHP2 inhibition triggers anti-tumor immunity and synergizes with PD-1 blockade.
Signatures and Specificity of Tissue-Resident Lymphocytes Identified in Human Renal Peritumor and Tumor Tissue.
Solid tumor-targeted infiltrating cytotoxic T lymphocytes retained by a superantigen fusion protein.
Structure and Function of HLA-A*02-Restricted Hantaan Virus Cytotoxic T-Cell Epitope That Mediates Effective Protective Responses in HLA-A2.1/K(b) Transgenic Mice.
Studies of hormonal regulation, phenotype plasticity, bone metastasis, and experimental therapeutics in androgen-repressed human prostate cancer (ARCaP) model.
Subcutaneous panniculitis-like T-cell lymphoma: presentation of 2 cases and observations.
SUMO2 overexpression enhances the generation and function of interleukin-17-producing CD8(+) T cells in mice.
Suppression of granzyme B activity and caspase-3 activation in leukaemia cells constitutively expressing the protease inhibitor 9.
Survivin and Granzyme B-induced apoptosis, a novel anticancer therapy.
Synergistic roles of granzymes A and B in mediating target cell death by rat basophilic leukemia mast cell tumors also expressing cytolysin/perforin.
Systematic analysis of immune infiltrates in high-grade serous ovarian cancer reveals CD20, FoxP3 and TIA-1 as positive prognostic factors.
T cell receptor-zeta and granzyme B expression in mononuclear cell infiltrates in normal colon mucosa and colon carcinoma.
T cells expressing NKG2D chimeric antigen receptors efficiently eliminate glioblastoma and cancer stem cells.
T lymphocyte SHP2-deficiency triggers anti-tumor immunity to inhibit colitis-associated cancer in mice.
T-cell TGF-? signaling abrogation restricts medulloblastoma progression.
T-Cell-Derived Nanovesicles for Cancer Immunotherapy.
TAGLN2-mediated actin stabilization at the immunological synapse: implication for cytotoxic T cell control of target cells.
Target Reprogramming Lysosomes of CD8+ T Cells by a Mineralized Metal-Organic Framework for Cancer Immunotherapy.
Targeted ex vivo reduction of CD64-positive monocytes in chronic myelomonocytic leukemia and acute myelomonocytic leukemia using human granzyme B-based cytolytic fusion proteins.
Targeted intracellular protein delivery based on hyaluronic acid-green tea catechin nanogels.
Targeting and Therapy of Glioblastoma in a Mouse Model Using Exosomes Derived From Natural Killer Cells.
Targeting CXCR4 potentiates anti-PD-1 efficacy modifying the tumor microenvironment and inhibiting neoplastic PD-1.
Targeting granzyme B to tumor cells using a yoked human chorionic gonadotropin.
Targeting miR-23a in CD8+ cytotoxic T lymphocytes prevents tumor-dependent immunosuppression.
Targeting of Tumor Neovasculature with GrB/VEGF121, a Novel Cytotoxic Fusion Protein.
Taste receptor T1R1/T1R3 promotes the tumoricidal activity of hepatic CD49a+ CD49b- natural killer cells.
Testicular natural killer/t-cell lymphoma, nasal type, of true natural killer-cell origin.
TGF-beta directly targets cytotoxic T cell functions during tumor evasion of immune surveillance.
The analysis of estrogen receptor-? positive breast cancer stem-like cells unveils a high expression of the serpin proteinase inhibitor PI-9: Possible regulatory mechanisms.
The Antidiabetic Agent Acarbose Improves Anti-PD-1 and Rapamycin Efficacy in Preclinical Renal Cancer.
The CD8 T cell response to vaccinia virus exhibits site-dependent heterogeneity of functional responses.
The combination of TLR-9 adjuvantation and electroporation mediated delivery enhances in vivo anti-tumor responses after vaccination with HPV-16 E7 encoding DNA.
The decreased susceptibility of metastatic melanoma cells to killing involves an alteration of CTL reactivity.
The effect of MEK1/2 inhibitors on cisplatin-induced acute kidney injury (AKI) and cancer growth in mice.
The exosomes derived from CAR-T cell efficiently target mesothelin and reduce triple-negative breast cancer growth.
The Herpes Simplex Virus Latency-Associated Transcript Gene Is Associated with a Broader Repertoire of Virus-Specific Exhausted CD8+ T Cells Retained within the Trigeminal Ganglia of Latently Infected HLA Transgenic Rabbits.
The high expression of Fractalkine results in a better prognosis for colorectal cancer patients.
The localization and density of immune cells in primary tumors of human metastatic colorectal cancer shows an association with response to chemotherapy.
The PD-1 expressing immune phenotype of T cell exhaustion is prominent in the 'immunoreactive' microenvironment of colorectal carcinoma.
The peptide loop consisting of amino acids 139-157 of human granzyme B (fragmentin 2) contains an immunodominant epitope recognized by the mouse.
The pharmalogical reactivation of p53 function improves breast tumor cell lysis by granzyme B and NK cells through induction of autophagy.
The phenotype and activation status of regulatory T cells during Friend retrovirus infection.
The Potential Roles of Mucosa-Associated Invariant T Cells in the Pathogenesis of Gut Graft-Versus-Host Disease After Hematopoietic Stem Cell Transplantation.
The Profile and Role of Tumor-infiltrating Lymphocytes in Hepatocellular Carcinoma: An Immunohistochemical Study.
The ratio of intra-tumoral regulatory T cells (Foxp3+)/helper T cells (CD4+) is a prognostic factor and associated with recurrence pattern in gastric cardia cancer.
The Role of Autophagy in Tumor Immunology-Complex Mechanisms That May Be Explored Therapeutically.
The role of cytotoxic and regulatory T cells in relapsed/refractory Hodgkin lymphoma.
The Role of Indoleamine 2,3-Dioxygenase in Diethylnitrosamine-Induced Liver Carcinogenesis.
The significance of granzyme B expression in patients with angiocentric lymphoma of the head and neck.
The use of a TLR2 agonist-based adjuvant for enhancing effector and memory CD8 T-cell responses.
Therapeutic blockade of activin-A improves NK cell function and antitumor immunity.
Time post-lung transplant correlates with increasing peripheral blood T cell granzyme B and proinflammatory cytokines.
Tolerization of tumor-specific T cells despite efficient initial priming in a primary murine model of prostate cancer.
Topical treatment of all-trans retinoic acid inhibits murine melanoma partly by promoting CD8(+) T-cell immunity.
Tr1 responses are elevated in asymptomatic H. pylori-infected individuals and are functionally impaired in H. pylori-gastric cancer patients.
Trafficking phenotype and production of granzyme B by double negative B cells (IgG(+)IgD(-)CD27(-)) in the elderly.
TRAIL-Receptor 4 Modulates ?? T Cell-Cytotoxicity Toward Cancer Cells.
Treatment combining RU486 and Ad5IL-12 vector attenuates the growth of experimentally formed prostate tumors and induces changes in the tumor sentinel lymph nodes of mice.
Trichosanthin cooperates with Granzyme B to restrain tumor formation in tongue squamous cell carcinoma.
Trichosanthin increases Granzyme B penetration into tumor cells by upregulation of CI-MPR on the cell surface.
Triple costimulation via CD80, 4-1BB, and CD83 ligand elicits the long-term growth of V?9V?2 T cells in low levels of IL-2.
Triple Therapy with MerTK and PD1 Inhibition plus Radiotherapy Promotes Abscopal Antitumor Immune Responses.
Truncated CD200 stimulates tumor immunity leading to fewer lung metastases in a novel Wistar rat metastasis model.
Tumor Infiltrating Effector Memory Antigen-Specific CD8+ T Cells Predict Response to Immune Checkpoint Therapy.
Tumor Lactic Acidosis: Protecting Tumor by Inhibiting Cytotoxic Activity Through Motility Arrest and Bioenergetic Silencing.
Tumor location impacts immune response in mouse models of colon cancer.
Tumor perfusion enhancement by ultrasound stimulated microbubbles potentiates PD-L1 blockade of MC38 colon cancer in mice.
Tumor-derived granzyme B-expressing neutrophils acquire antitumor potential after lipid A treatment.
Tumor-infiltrating mucosal-associated invariant T (MAIT) cells retain expression of cytotoxic effector molecules.
Tumor-infiltrating regulatory T cells inhibit endogenous cytotoxic T cell responses to lung adenocarcinoma.
Tumor-specific CD4(+) T cells develop cytotoxic activity and eliminate virus-induced tumor cells in the absence of regulatory T cells.
Tumor-targeted 4-1BB agonists for combination with T cell bispecific antibodies as off-the-shelf therapy.
Tumoricidal activity of TLR7/8-activated inflammatory dendritic cells.
Tumour-infiltrating lymphocytes in colorectal cancer with microsatellite instability are activated and cytotoxic.
Type I interferon-associated recruitment of cytotoxic lymphocytes: a common mechanism in regressive melanocytic lesions.
Understanding key assay parameters that affect measurements of trastuzumab-mediated ADCC against Her2 positive breast cancer cells.
Up-regulation of alternate co-stimulatory molecules on proinflammatory CD28null T cells in bronchiolitis obliterans syndrome.
Up-regulation of granzyme B and perforin by staphylococcal enterotoxin C2 mutant induces enhanced cytotoxicity in Hepa1-6 cells.
Valproic acid triggers radiation-induced abscopal effect by modulating the unirradiated tumor immune microenvironment in a rat model of breast cancer.
Villus epithelial injury induced by infection with the nematode Nippostrongylus brasiliensis is associated with upregulation of granzyme B.
Warburg phenotype in renal cell carcinoma: High expression of glucose-transporter 1 (GLUT-1) correlates with low CD8(+) T-cell infiltration in the tumor.
ZIKA virus infection causes persistent chorioretinal lesions.
Zoledronate facilitates large-scale ex vivo expansion of functional gammadelta T cells from cancer patients for use in adoptive immunotherapy.
[Aggressive NK/T cell leukemia/lymphoma associated with EBV].
[Clinicopathological characteristics of adult T cell leukemia/lymphoma].
[Correlation analysis of the prognosis of HPV positive oropharyngeal cancer patients with T cell infiltration and neoantigen load].
[Diffuse large B-cell lymphoma with aberrant expression of CD56: a clinicopathologic and immunohistochemical study].
[Effect of bushen recipe on the immune effector molecules of natural killer cells in patients with chronic hepatitis B]
[Expression profile of immune effector molecules in natural killer cells in patients with chronic hepatitis B]
[Isolated central nervous system relapse in type II enteropathy-associated T cell lymphoma].
[Kv1.3 potassium channel expression changes after CD4(+) and subsets CD28(null)/CD28(+)T cells activation in peripheral blood of patients with acute coronary syndrome]
[Primary nasal natural killer/T-cell lymphomas: classification and clinicopathological features]
[The modulatory activity of T cell immunoglobulin and mucin domain-containing protein 3 on T lymphocytes in patients with chronic heart failure].
Neuroblastoma
Ex vivo activation of CD56+ immune cells that eradicate neuroblastoma.
Neuroinflammatory Diseases
c-Met is expressed by highly autoreactive encephalitogenic CD8+ cells.
Eomesodermin-expressing T-helper cells are essential for chronic neuroinflammation.
Pathological mechanism of secondary-progressive multiples sclerosis and its animal model.
Protease-activated receptor-1 activation by granzyme B causes neurotoxicity that is augmented by interleukin-1?.
Neuromyelitis Optica
Paucity of natural killer and cytotoxic T cells in human neuromyelitis optica lesions.
Neutropenia
Chronic clonal proliferative disease of gamma-delta (gammadelta) T-cells in a patient with rheumatoid arthritis and neutropenia: lack of the morphology and the immunophenotype of large granular lymphocytes.
Nevus
Type I interferon-associated recruitment of cytotoxic lymphocytes: a common mechanism in regressive melanocytic lesions.
Nevus, Halo
A similar local immune and oxidative stress phenotype in vitiligo and halo nevus.
Type I interferon-associated recruitment of cytotoxic lymphocytes: a common mechanism in regressive melanocytic lesions.
Newcastle Disease
Non-replicating Newcastle Disease Virus as an adjuvant for DNA vaccine enhances antitumor efficacy through the induction of TRAIL and granzyme B expression.
Non-alcoholic Fatty Liver Disease
Nutrigenetic Interactions Might Modulate the Antioxidant and Anti-Inflammatory Status in Mastiha-Supplemented Patients With NAFLD.
Obesity
Granzyme B Expression in Visceral Adipose Tissue Associates With Local Inflammation and Glyco-Metabolic Alterations in Obesity.
Overweight and obese adult humans have a defective cellular immune response to pandemic H1N1 influenza A virus.
The serine protease granzyme B as an inflammatory marker, in relation to the insulin receptor cleavage in human obesity and type 2 diabetes mellitus.
Obstetric Labor, Premature
Effector and Activated T Cells Induce Preterm Labor and Birth That Is Prevented by Treatment with Progesterone.
Osteosarcoma
Interleukin-35 suppresses antitumor activity of circulating CD8+ T cells in osteosarcoma patients.
MicroRNA-200a induces immunosuppression by promoting PTEN-mediated PD-L1 upregulation in osteosarcoma.
PD?L1/PD?1 axis serves an important role in natural killer cell?induced cytotoxicity in osteosarcoma.
Overweight
Overweight and obese adult humans have a defective cellular immune response to pandemic H1N1 influenza A virus.
Pancreatic Neoplasms
CD40 Agonist Overcomes T Cell Exhaustion Induced by Chronic Myeloid Cell IL-27 Production in a Pancreatic Cancer Preclinical Model.
Engraftment of mesothelin chimeric antigen receptor using a hybrid Sleeping Beauty/minicircle vector into NK-92MI cells for treatment of pancreatic cancer.
Papillon-Lefevre Disease
A family with Papillon-Lefevre syndrome reveals a requirement for cathepsin C in granzyme B activation and NK cell cytolytic activity.
Paracoccidioidomycosis
Characterization of cytotoxic immune response in skin and mucosal lesions of paracoccidioidomycosis.
Paramyxoviridae Infections
Specific inhibition of granzyme B by parainfluenza virus type 3.
Pemphigoid, Bullous
Collagen XVII Processing and Blistering Skin Diseases.
Granzyme B inhibition reduces disease severity in autoimmune blistering diseases.
Peptic Ulcer
Perforin and granzyme B of cytotoxic T lymphocyte mediate apoptosis irrespective of Helicobacter pylori infection: possible act as a trigger of peptic ulcer formation.
Persistent Infection
Collapse of Cytolytic Potential in SIV-Specific CD8+ T Cells Following Acute SIV Infection in Rhesus Macaques.
Lymphocytic choriomeningitis virus persistence promotes effector-like memory differentiation and enhances mucosal T cell distribution.
Pleural Effusion
Enhanced immune response of MAIT cells in tuberculous pleural effusions depends on cytokine signaling.
Potential Role of Pleural Fluid Cytokine Profile in Myelomatous Pleural Effusions.
Pneumocystis Infections
Memory CD4+ T cells are required for optimal NK cell effector functions against the opportunistic fungal pathogen Pneumocystis murina.
Pneumonia
Granzyme B deficiency exacerbates lung inflammation in mice after acute lung injury.
Natural killer cell NKG2D and granzyme B are critical for allergic pulmonary inflammation.
Perforin and granzyme B gene-expressing cells in bronchoalveolar lavage fluids from lung allograft recipients displaying cytomegalovirus pneumonitis.
Regulatory T cells expressing granzyme B play a critical role in controlling lung inflammation during acute viral infection.
Pneumovirus Infections
Granzyme A- and B-cluster deficiency delays acute lung injury in pneumovirus-infected mice.
Polymyositis
Expression of human IAP-like protein in skeletal muscle: a possible explanation for the rare incidence of muscle fiber apoptosis in T-cell mediated inflammatory myopathies.
Polymyositis in solid organ transplant recipients receiving tacrolimus.
Poxviridae Infections
A pro-survival role for the intracellular granzyme B inhibitor Serpinb9 in natural killer cells during poxvirus infection.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Genetic variants of human granzyme B predict transplant outcomes after HLA matched unrelated bone marrow transplantation for myeloid malignancies.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
A novel CD7 chimeric antigen receptor-modified NK-92MI cell line targeting T-cell acute lymphoblastic leukemia.
The presence of CD56/CD16 in T-cell acute lymphoblastic leukaemia correlates with the expression of cytotoxic molecules and is associated with worse response to treatment.
Primary Myelofibrosis
[Bone marrow-restricted involvement of T-cell granular lymphocyte leukemia]
Prostatic Neoplasms
A Possible Role for Perforin and Granzyme B in Resveratrol Enhanced Radiosensitivity of Prostate Cancer.
Granzyme B proteolyzes receptors important to proliferation and survival, tipping the balance toward apoptosis.
Inhibition of Granzyme B by PI-9 protects prostate cancer cells from apoptosis.
Secretome analysis reveals upregulated granzyme B in human androgen-repressed prostate cancer cells with mesenchymal and invasive phenotype.
[Increased Notch receptors induces CD8(+) T cell exhaustion in patients with prostate cancer].
Prostatitis
Oxidative stress in prostatic fluid of patients with chronic pelvic pain syndrome: correlation with gram positive bacterial growth and treatment response.
Pruritus
Relationships among plasma granzyme B level, pruritus and dermatitis in patients with atopic dermatitis.
Psoriasis
A comparative study of the expression of cytotoxic proteins in allergic contact dermatitis and psoriasis: spongiotic skin lesions in allergic contact dermatitis are highly infiltrated by T cells expressing perforin and granzyme B.
Cytotoxic T lymphocytes as a potential brake of keratinocyte proliferation in psoriasis.
Perforin and granzyme B may contribute to skin inflammation in atopic dermatitis and psoriasis.
Pulmonary Arterial Hypertension
Epsin15 Homology Domains: Role in the Pathogenesis of Pulmonary Arterial Hypertension.
Granzyme B deficiency promotes osteoblastic differentiation and calcification of vascular smooth muscle cells in hypoxic pulmonary hypertension.
Pulmonary Disease, Chronic Obstructive
A possible role for CD8(+) and non-CD8(+) cell granzyme B in early small airway wall remodeling in centrilobular emphysema.
Enhanced cytotoxic function of natural killer and natural killer T-like cells associated with decreased CD94 (Kp43) in the chronic obstructive pulmonary disease airway.
Enhanced effector function of cytotoxic cells in the induced sputum of COPD patients.
Increased airway granzyme b and perforin in current and ex-smoking COPD subjects.
Increased CD8 T-cell granzyme B in COPD is suppressed by treatment with low-dose azithromycin.
Role of increased CD8/CD28(null) T cells and alternative co-stimulatory molecules in chronic obstructive pulmonary disease.
Targeting peripheral blood pro-inflammatory cytotoxic lymphocytes by inhibiting CD137 expression: novel potential treatment for COPD.
The drug efflux pump Pgp1 in pro-inflammatory lymphocytes is a target for novel treatment strategies in COPD.
The effects of BAFF on T lymphocytes in chronic obstructive pulmonary disease.
The possible role of granzyme B in the pathogenesis of chronic obstructive pulmonary disease.
The Role of Granzyme B Containing Cells in the Progression of Chronic Obstructive Pulmonary Disease.
Pulmonary Emphysema
A possible role for CD8(+) and non-CD8(+) cell granzyme B in early small airway wall remodeling in centrilobular emphysema.
Pulmonary Fibrosis
Subset-specific alterations in frequencies and functional signatures of ?? T cells in systemic sclerosis patients.
Renal Insufficiency, Chronic
Plasma granzyme B as a predicting factor of coronary artery disease-Clinical significance in patients with chronic renal failure.
Retinitis
ZIKA virus infection causes persistent chorioretinal lesions.
Salmonella Infections
MHC class-I-restricted CD8 T cells play a protective role during primary Salmonella infection.
Sarcoma
Human granzyme B degrades aggrecan proteoglycan in matrix synthesized by chondrocytes.
Normalization of tumor microenvironment by neem leaf glycoprotein potentiates effector T cell functions and therapeutically intervenes in the growth of mouse sarcoma.
Schistosomiasis
Activation-induced T helper cell death contributes to Th1/Th2 polarization following murine Schistosoma japonicum infection.
Scleroderma, Systemic
Recognition of Granzyme B-generated autoantigen fragments in scleroderma patients with ischemic digital loss.
Sepsis
Notch signaling pathway regulates T cell dysfunction in septic patients.
Platelets Induce Apoptosis during Sepsis in a Contact-Dependent Manner That Is Inhibited by GPIIb/IIIa Blockade.
Sepsis alters the megakaryocyte-platelet transcriptional axis resulting in granzyme B-mediated lymphotoxicity.
Upregulation of two death pathways of perforin/granzyme and FasL/Fas in septic acute respiratory distress syndrome.
Shock, Septic
Notch signaling pathway regulates T cell dysfunction in septic patients.
Skin Diseases
Granzyme B as a therapeutic target for wound healing.
Small Cell Lung Carcinoma
Frequent T cell responses against immunogenic targets in lung cancer patients for targeted immunotherapy.
Spinal Cord Injuries
Granzyme-b mediated cell death in the spinal cord-injured rat model.
Spondylarthropathies
Raised granzyme B levels are associated with erosions in patients with early rheumatoid factor positive rheumatoid arthritis.
Squamous Cell Carcinoma of Head and Neck
Correlation of P53 and Granzyme B expression in Oral Squamous Cell Carcinoma with Clinicopathologic Findings.
Distinct expression of perforin and granzyme B in lip and oral cavity squamous cell carcinoma.
Granzyme B-truncated VEGF fusion protein represses angiogenesis and tumor growth of OSCC.
The clinicopathological significance of the expression of Granzyme B in oral squamous cell carcinoma.
ST Elevation Myocardial Infarction
Plasma granzyme B in ST elevation myocardial infarction versus non-ST elevation acute coronary syndrome: comparisons with IL-18 and fractalkine.
Stevens-Johnson Syndrome
Diagnostic Tools and Biomarkers for Severe Drug Eruptions.
Phenotypic diversity in delayed drug hypersensitivity: an immunologic explanation.
Stomach Neoplasms
Exploitation of interleukin-18 by gastric cancers for their growth and evasion of host immunity.
Intratumoral CD103+CD4+ T cell infiltration defines immunoevasive contexture and poor clinical outcomes in gastric cancer patients.
[Mechanistic study of nimesulide on enhancing gammadeltaT cell-mediated killing of gastric cancer cells.]
Stroke
Role of Cytotoxic Protease Granzyme-b in Neuronal Degeneration during Human Stroke.
Subacute Sclerosing Panencephalitis
Granzyme B gene polymorphism associated with subacute sclerosing panencephalitis.
Synovitis
Monoclonal anti-CD8 therapy induces disease amelioration in the K/BxN mouse model of spontaneous chronic polyarthritis.
Teratocarcinoma
Apoptosis of the teratocarcinoma cell line Tera-1 leads to the cleavage of HERV-K10gag proteins by caspases and/or granzyme B.
Teratoma
EGFR806-CAR T cells selectively target a tumor-restricted EGFR epitope in glioblastoma.
Tetanus
Characterisation of immune responses in healthy foals when a multivalent vaccine protocol was initiated at age 90 or 180 days.
Identification of a potent regulatory T cell epitope in factor V that modulates CD4+ and CD8+ memory T cell responses.
Presentation of soluble antigens to CD8+ T cells by CpG oligodeoxynucleotide-primed human naive B cells.
Thyroiditis
Association of increased eomesodermin, BCL6, and granzyme B expression with major clinical manifestations of Hashimoto's thyroiditis - an observational study.
Expression of CD40 and apoptosis related molecules in autoimmune thyroid diseases.
Tonsillitis
Spatially visualized single-cell pathology of highly multiplexed protein profiles in health and disease.
Tuberculosis
Distinct functions of CXCR3+ and CCR4+CD4+ T-cells accumulated in human tuberculosis pleural fluid.
Granzyme B as a diagnostic marker of tuberculosis in patients with and without HIV coinfection.
Granzyme B Attenuates Bacterial Virulence by Targeting Secreted Factors.
Granzyme B Disrupts Central Metabolism and Protein Synthesis in Bacteria to Promote an Immune Cell Death Program.
Granzyme B induced by Rv0140 antigen discriminates latently infected from active tuberculosis individuals.
Granzyme B-expressing neutrophils correlate with bacterial load in granulomas from Mycobacterium tuberculosis-infected cynomolgus macaques.
Rat CD4+CD8+ Macrophages Kill Tumor Cells through an NKG2D- and Granzyme/Perforin-Dependent Mechanism.
Typhoid Fever
Expression of intra- and extracellular granzymes in patients with typhoid fever.
Urinary Bladder Neoplasms
Anaplastic lymphoma kinase-positive anaplastic large cell lymphoma presenting as a bladder neoplasm.
Docosahexaenoic acid inhibits invasion of human RT112 urinary bladder and PT45 pancreatic carcinoma cells via down-modulation of granzyme B expression.
Uterine Cervical Neoplasms
A reversed CD4/CD8 ratio of tumor-infiltrating lymphocytes and a high percentage of CD4(+)FOXP3(+) regulatory T cells are significantly associated with clinical outcome in squamous cell carcinoma of the cervix.
Blockade of BAFF Receptor BR3 on T Cells Enhances Their Activation and Cytotoxicity.
Targeted biological effect of an affitoxin composed of an HPV16E7 affibody fused with granzyme B (ZHPV16E7-GrB) against cervical cancer in vitro and in vivo.
Vaccinia
Augmented replicative capacity of the boosting antigen improves the protective efficacy of heterologous prime-boost vaccine regimens.
Differential regulation of granzyme and perforin in effector and memory T cells following smallpox immunization.
Granzyme B inhibits vaccinia virus production through proteolytic cleavage of eukaryotic initiation factor 4 gamma 3.
Vascular Calcification
Granzyme B deficiency promotes osteoblastic differentiation and calcification of vascular smooth muscle cells in hypoxic pulmonary hypertension.
Vascular Diseases
Granzyme B in atherosclerosis and transplant vascular disease: association with cell death and atherosclerotic disease severity.
Granzyme B induces endothelial cell apoptosis and contributes to the development of transplant vascular disease.
Granzyme B induces smooth muscle cell apoptosis in the absence of perforin: involvement of extracellular matrix degradation.
Vasculitis
Histologic and Immunohistochemical Evaluation of Infiltrating Inflammatory Cells in Kawasaki Disease Arteritis Lesions.
Serum granzyme B is associated with otorhinolaryngological, pulmonary, and renal involvement of antineutrophil cytoplasmic antibody-associated vasculitis.
Vesicular Stomatitis
Granzyme B independently of perforin mediates noncytolytic intracellular inactivation of vesicular stomatitis virus.
Viremia
Balance between activation and regulation of HIV-specific CD8+ T-cell response after modified vaccinia Ankara B therapeutic vaccination.
Virus Diseases
A natural genetic variant of granzyme B confers lethality to a common viral infection.
A triple-mutated allele of granzyme B incapable of inducing apoptosis.
Activating KIR copy number variation is associated with granzyme B release by NK cells during primary simian immunodeficiency virus infection in rhesus monkeys.
Antigenic Re-Stimulation of Virus-Specific Memory CD8+ T Cells Requires Days of Lytic Protein Accumulation for Maximal Cytotoxic Capacity.
Apoptosis of lymphocytes and monocytes infected with influenza virus might be the mechanism of combating virus and causing secondary infection by influenza.
Assessment of markers of the cell-mediated immune response after influenza virus infection in frail older adults.
CD8+CD57+ T cells exhibit distinct features in human non-small cell lung cancer.
Chronic HIV infection affects the expression of the 2 transcription factors required for CD8 T-cell differentiation into cytolytic effectors.
Control of lymphocytic choriomeningitis virus infection in granzyme B deficient mice.
Cutting edge: Persistently open chromatin at effector gene loci in resting memory CD8+ T cells independent of transcriptional status.
CXCR3 deficiency increases susceptibility to genital herpes simplex virus type 2 infection: Uncoupling of CD8+ T-cell effector function but not migration.
Dok-1 and Dok-2 Regulate the Formation of Memory CD8+ T Cells.
Frequency, specificity, and sites of expansion of CD8+ T cells during primary pulmonary influenza virus infection.
Granzyme B is inhibited by the cowpox virus serpin cytokine response modifier A.
Granzyme B regulates antiviral CD8+ T cell responses.
Granzymes and caspase 3 play important roles in control of gammaherpesvirus latency.
Granzymes: a variety of serine protease specificities encoded by genetically distinct subfamilies.
Highly differentiated, resting gn-specific memory CD8+ T cells persist years after infection by andes hantavirus.
Independence of Granzyme B Secretion and Interferon- gamma Production during Acute Simian Immunodeficiency Virus Infection.
IRF3 deficiency impacts granzyme B expression and maintenance of memory T cell function in response to viral infection.
Isolation and characterization of novel single-chain Fv specific for human granzyme B.
Local blockade of epithelial PDL-1 in the airways enhances T cell function and viral clearance during influenza virus infection.
Properties of murine (CD8+)CD27- T cells.
Regulatory T cells expressing granzyme B play a critical role in controlling lung inflammation during acute viral infection.
Selective expansion of a peripheral blood CD8+ memory T cell subset expressing both granzyme B and L-selectin during primary viral infection in renal allograft recipients.
Suppressed expression of miR-378 targeting gzmb in NK cells is required to control dengue virus infection.
The innate antiviral immune system of the cat: Molecular tools for the measurement of its state of activation.
Vitiligo
A similar local immune and oxidative stress phenotype in vitiligo and halo nevus.
Genetic polymorphisms of GZMB and vitiligo: A genetic association study based on Chinese Han population.
The Role of TRM Cells in the Pathogenesis of Vitiligo-A Review of the Current State-Of-The-Art.
Tissue-resident memory T cells in the skin.
West Nile Fever
Correlation of Regulatory T Cell Numbers with Disease Tolerance upon Virus Infection.