3.4.21.69: Protein C (activated)

This is an abbreviated version!
For detailed information about Protein C (activated), go to the full flat file.

Word Map on EC 3.4.21.69

3.4.21.69

thrombosis

venous

leiden

sepsis

endothelial

antithrombin

thromboembolism

thrombophilia

clot

thrombomodulin

platelet

procoagulant

heparin

arterial

vein

bleeding

plasminogen

hypercoagulable

thromboplastin

lupus

fibrinogen

fibrinolysis

hemostatic

viiia

epcr

intravascular

contraceptive

antiphospholipid

antithrombotic

prothrombotic

fibrin

k-dependent

anticardiolipin

d-dimers

coagulopathy

embolism

prothrombinase

amidolytic

thrombin-antithrombin

haemostasis

par1

profibrinolytic

pharmacology

goal-directed

diagnostics

drug development

gamma-carboxyglutamic

deep-vein

time-based

tafi

hypofibrinolysis

thromboprophylaxis

medicine

protac

Reaction

degradation of blood coagulation factors Va and VIIIa =

Synonyms

Activated blood coagulation factor XIV, Activated protein C, anticoagulant activated protein C, anticoagulant protein C/protein S system, anticoagulant serine protease-activated protein C, anticoagulant-activated protein C, APC, Autoprothrombin II-A, Autoprothrombin IIA, Blood coagulation factor XIV, Blood-coagulation factor XIV, activated, Blood-coagulation factor XIVa, ghrelin endopeptidase, GSAPC, hAPC, PROC, Protein Ca, rhAPC

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.21 Serine endopeptidases

3.4.21.69 Protein C (activated)

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Results	in table
34	Activating Compound
56	AA Sequence
22	Application
1	CAS Registry Number
20	Cloned(Commentary)
23	Cofactor
10912	Disease/ Diagnostics
1	Expression
61	General Information
41	IC50 Value
105	Inhibitors
1	kcat/KM [mM/s]
42	KM Value [mM]
19	Localization
35	Metals/Ions
12	Molecular Weight [Da]
105	Natural Substrates/ Products (Substrates)
357	Organism
16	PDB ID
15	pH Optimum
26	Posttranslational Modification
71	Protein Variants
14	Purification (Commentary)
2	Reaction
1	Reaction Type
136	Reference
109	Source Tissue
7	Specific Activity [micromol/min/mg]
230	Substrates and Products (Substrate)
10	Subunits
173	Synonyms
18	Temperature Optimum [°C]
24	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 3.4.21.69 - Protein C (activated)

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0.0028

N-(2-carboxyethyl)-3-cyclohexyl-L-alanyl-N-(4-carbamimidoylbenzyl)argininamide

Homo sapiens

pH 7.4, 37°C

731459

0.0031

N-(4-carbamimidoylbenzyl)-2-[(3-cyclohexyl-L-alanyl)amino]-4-(piperidin-4-yl)butanamide

Homo sapiens

pH 7.4, 37°C

731459

0.044

N-(4-[2-[(4-carbamimidoylbenzyl)carbamoyl]-2,3-dihydro-1H-inden-2-yl]-2,2-dimethyl-4-oxobutyl)glycine

Homo sapiens

683754

0.033

N-(4-[2-[(4-carbamimidoylbenzyl)carbamoyl]-2,3-dihydro-1H-inden-2-yl]-2-cyclohexyl-4-oxobutyl)glycine

Homo sapiens

above

683754

0.033

N-(4-[2-[(4-carbamimidoylbenzyl)carbamoyl]-2,3-dihydro-1H-inden-2-yl]-4-oxobutyl)glycine

Homo sapiens

above

683754

0.0011

N-(carboxymethyl)-3-cyclohexyl-D-alanyl-4-(aminomethyl)-N-(4-carbamimidoylbenzyl)phenylalaninamide

Homo sapiens

pH 7.4, 37°C

731459

0.00013

N-(carboxymethyl)-3-cyclohexyl-D-alanyl-4-amino-N-(4-carbamimidoylbenzyl)-D-phenylalaninamide

Homo sapiens

pH 7.4, 37°C

731459

0.0038

N-(carboxymethyl)-3-cyclohexyl-D-alanyl-N-(4-carbamimidoylbenzyl)-4-cyanophenylalaninamide

Homo sapiens

pH 7.4, 37°C

731459

0.00067

N-(carboxymethyl)-3-cyclohexyl-D-alanyl-N-(4-carbamimidoylbenzyl)-D-phenylalaninamide

Homo sapiens

pH 7.4, 37°C

731459

0.00026

N-(carboxymethyl)-3-cyclohexyl-D-alanyl-N-(4-carbamimidoylbenzyl)-D-tyrosinamide

Homo sapiens

pH 7.4, 37°C

731459

0.0013

N-(carboxymethyl)-3-cyclohexyl-L-alanyl-N-(4-carbamimidoylbenzyl)-3-piperidin-4-ylalaninamide

Homo sapiens

pH 7.4, 37°C

731459

0.044

N-(carboxymethyl)-3-cyclohexyl-L-alanyl-N-(4-carbamimidoylbenzyl)-3-pyrrolidin-2-yl-D-alaninamide

Homo sapiens

above, pH 7.4, 37°C

731459

0.0056

N-(carboxymethyl)-3-cyclohexyl-L-alanyl-N-(4-carbamimidoylbenzyl)-3-pyrrolidin-2-yl-L-alaninamide

Homo sapiens

pH 7.4, 37°C

731459

0.00047

N-(carboxymethyl)-3-cyclohexyl-L-alanyl-N-(4-carbamimidoylbenzyl)argininamide

Homo sapiens

pH 7.4, 37°C

731459

0.044

N-[(1S)-2-([1-[(4-carbamimidoylbenzyl)amino]-1-oxo-4-(piperidin-4-yl)butan-2-yl]amino)-1-cyclohexyl-2-oxoethyl]glycine

Homo sapiens

above, pH 7.4, 37°C

731459

0.0017

N-[(1S)-2-([2-[(4-carbamimidoylbenzyl)carbamoyl]-2,3-dihydro-1H-inden-2-yl]amino)-1-cyclohexyl-2-oxoethyl]glycine

Homo sapiens

pH 7.4, 37°C

731459

0.00112

N-[(2R)-2-(2-[2-[(4-carbamimidoylbenzyl)carbamoyl]-2,3-dihydro-1H-inden-2-yl]-2-oxoethyl)-3-methylpentyl]glycine

Homo sapiens

683754

0.00075

N-[(2R)-2-(2-[2-[(4-carbamimidoylbenzyl)carbamoyl]-2,3-dihydro-1H-inden-2-yl]-2-oxoethyl)-4-methylpentyl]glycine

Homo sapiens

683754

0.01125

N-[(2R)-2-benzyl-4-[2-[(4-carbamimidoylbenzyl)carbamoyl]-2,3-dihydro-1H-inden-2-yl]-4-oxobutyl]glycine

Homo sapiens

683754

0.0001

N-[(2R)-4-[2-[(4-carbamimidoylbenzyl)carbamoyl]-2,3-dihydro-1H-inden-2-yl]-2-(cyclohexylmethyl)-4-oxobutyl]glycine

Homo sapiens

683754

0.00204

N-[(2R)-4-[2-[(4-carbamimidoylbenzyl)carbamoyl]-2,3-dihydro-1H-inden-2-yl]-2-ethyl-4-oxobutyl]glycine

Homo sapiens

683754

0.00908

N-[(2R)-4-[2-[(4-carbamimidoylbenzyl)carbamoyl]-2,3-dihydro-1H-inden-2-yl]-2-methyl-4-oxobutyl]glycine

Homo sapiens

683754

0.0092

N-[(2S)-1-([1-[(4-carbamimidoylbenzyl)amino]-1-oxo-4-(piperidin-4-yl)butan-2-yl]amino)-3-cyclohexyl-1-oxopropan-2-yl]glycine

Homo sapiens

pH 7.4, 37°C

731459

0.0031

N-[(2S)-1-[[(1S)-2-[(4-carbamimidoylbenzyl)amino]-2-oxo-1-(piperidin-4-yl)ethyl]amino]-3-cyclohexyl-1-oxopropan-2-yl]glycine

Homo sapiens

pH 7.4, 37°C

731459

0.00383

N-[(2S)-2-(2-[2-[(4-carbamimidoylbenzyl)carbamoyl]-2,3-dihydro-1H-inden-2-yl]-2-oxoethyl)-3,3-dimethylbutyl]glycine

Homo sapiens

683754

0.00071

N-[(2S)-2-([1-benzyl-2-[(4-carbamimidoylbenzyl)amino]-2-oxoethyl]carbamoyl)-3-methylbutyl]glycine

Homo sapiens

683754

0.00035

N-[(2S)-2-([2-[(4-carbamimidoylbenzyl)amino]-1-(2,3-dihydro-1H-inden-2-yl)-2-oxoethyl]carbamoyl)-3-methylbutyl]glycine

Homo sapiens

683754

0.033

N-[(2S)-2-([2-[(4-carbamimidoylbenzyl)amino]-1-(diphenylmethyl)-2-oxoethyl]carbamoyl)-3-methylbutyl]glycine

Homo sapiens

above

683754

0.00025

N-[(2S)-2-([2-[(4-carbamimidoylbenzyl)carbamoyl]-2,3-dihydro-1H-cyclopenta[a]naphthalen-2-yl]carbamoyl)-3-methylbutyl]glycine

Homo sapiens

683754

0.00928

N-[(2S)-2-([2-[(4-carbamimidoylbenzyl)carbamoyl]-2,3-dihydro-1H-cyclopenta[b]naphthalen-2-yl]carbamoyl)-3-methylbutyl]glycine

Homo sapiens

683754

0.00043

N-[(2S)-2-([2-[(4-carbamimidoylbenzyl)carbamoyl]-2,3-dihydro-1H-phenalen-2-yl]carbamoyl)-3-methylbutyl]glycine

Homo sapiens

683754

0.01091

N-[(2S)-2-([2-[(4-carbamimidoylbenzyl)carbamoyl]-5,6-dimethoxy-2,3-dihydro-1H-inden-2-yl]carbamoyl)-3-methylbutyl]glycine

Homo sapiens

683754

0.0011

N-[(2S)-2-([6-[(4-carbamimidoylbenzyl)carbamoyl]-6,7-dihydro-5H-cyclopenta[b]pyridin-6-yl]carbamoyl)-3-methylbutyl]glycine

Homo sapiens

683754

0.0017

N-[(2S)-2-([6-[(4-carbamimidoylbenzyl)carbamoyl]-6,7-dihydro-5H-cyclopenta[c]pyridin-6-yl]carbamoyl)-3-methylbutyl]glycine

Homo sapiens

683754

0.01265

N-[(2S)-2-([6-[(4-carbamimidoylbenzyl)carbamoyl]-6,7-dihydro-5H-dibenzo[a,c][7]annulen-6-yl]carbamoyl)-3-methylbutyl]glycine

Homo sapiens

683754

0.0008

N-[(2S)-4-[2-[(4-carbamimidoylbenzyl)carbamoyl]-2,3-dihydro-1H-inden-2-yl]-2-(1-methylethyl)-4-oxobutyl]glycine

Homo sapiens

683754

0.00082

N-[(2S)-4-[2-[(4-carbamimidoylbenzyl)carbamoyl]-2,3-dihydro-1H-inden-2-yl]-2-cyclohexyl-4-oxobutyl]glycine

Homo sapiens

683754

0.053

N-[[1-(2-[2-[(4-carbamimidoylbenzyl)carbamoyl]-2,3-dihydro-1H-inden-2-yl]-2-oxoethyl)cyclopentyl]methyl]glycine

Homo sapiens

683754

0.0016

N2-[(2S)-2-amino-2-cyclohexylacetyl]-N-(4-carbamimidoylbenzyl)argininamide

Homo sapiens

pH 7.4, 37°C

731459

0.0011

[[(2R)-1-[[(2R)-1-[(4-carbamimidoylbenzyl)amino]-3-(naphthalen-1-yl)-1-oxopropan-2-yl]amino]-3-cyclohexyl-1-oxopropan-2-yl]amino]acetic acid

Homo sapiens

pH 7.4, 37°C

731459

0.00098

[[(2R)-1-[[(2R)-1-[(4-carbamimidoylbenzyl)amino]-3-(naphthalen-2-yl)-1-oxopropan-2-yl]amino]-3-cyclohexyl-1-oxopropan-2-yl]amino]acetic acid

Homo sapiens

pH 7.4, 37°C

731459