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3.4.21.69: Protein C (activated)

This is an abbreviated version!
For detailed information about Protein C (activated), go to the full flat file.

Word Map on EC 3.4.21.69

Reaction

degradation of blood coagulation factors Va and VIIIa =

Synonyms

Activated blood coagulation factor XIV, Activated protein C, anticoagulant activated protein C, anticoagulant protein C/protein S system, anticoagulant serine protease-activated protein C, anticoagulant-activated protein C, APC, Autoprothrombin II-A, Autoprothrombin IIA, Blood coagulation factor XIV, Blood-coagulation factor XIV, activated, Blood-coagulation factor XIVa, ghrelin endopeptidase, GSAPC, hAPC, PROC, Protein Ca, rhAPC

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.69 Protein C (activated)

Cloned

Cloned on EC 3.4.21.69 - Protein C (activated)

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
APCTPTGla chimera, much more potent anticoagulant than wild-type APC in plasma
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expression in AV12-664 cells, activation with rat thrombomodulin/bovine thrombin complex
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expression of Gla domainless Protein C GDPC andGDPC E80K by the RSV-PL4 expression/purification vector system in human 293 cells
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expression of the mutant zymogen protein C(S360A) in HEK-293 cells
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expression of wild-type an dmutant enzymes in HEK-293 cells
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expression of wild-type and mutant enzymes in HEK-293 cells
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expression of wild-type and mutant enzymes in HEK-293 cells, secretion to the medium
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gene PROC, location on chromosome 1p13-14
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gene PROC, location on on chromosome 2 (2q13–q14)
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mutant cloned into pcDNA 3.1(+)/Hygro vector and expressed in HEK-293 cells
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protein C mutants prepared by PCR methods expressed in HEK293 cells
recombinant coexpression of hEPCR and PAR1 linked to an N-terminal alkaline phosphatase (AP) cleavage reporter and treatment with recombinant APC-b (APCN329Q) or N-glycosidase PNGase F-treated APC (APCPNG), in which all N-linked glycans are excised, in HEK 293-T cells, detection of PAR1 proteolysis on HEK 293T cells
recombinant expression of the enzyme, co-expression with SEAP from a SEAP-protease activated receptor 3 fusion protein in HEK-293 cells with or without stable endothelial protein C receptor coexpression
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stable, functional expression of wild-type and mutant enzymes in HEK-293 cells
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