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3.4.21.69: Protein C (activated)

This is an abbreviated version!
For detailed information about Protein C (activated), go to the full flat file.

Word Map on EC 3.4.21.69

Reaction

degradation of blood coagulation factors Va and VIIIa =

Synonyms

Activated blood coagulation factor XIV, Activated protein C, anticoagulant activated protein C, anticoagulant protein C/protein S system, anticoagulant serine protease-activated protein C, anticoagulant-activated protein C, APC, Autoprothrombin II-A, Autoprothrombin IIA, Blood coagulation factor XIV, Blood-coagulation factor XIV, activated, Blood-coagulation factor XIVa, ghrelin endopeptidase, GSAPC, hAPC, PROC, Protein Ca, rhAPC

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.69 Protein C (activated)

Application

Application on EC 3.4.21.69 - Protein C (activated)

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APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
diagnostics
endogenous protein C levels positively correlate with a positive outcome in patients with severe sepsis
drug development
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at therapeutically relevant concentrations, activated protein C suppresses the release of interleukin-6 from stimulated human neutrophils and inhibited chemotaxis, without affecting the respiratory burst, apoptosis, and expression of other key cytokines. These effects are likely to be cell-type specific but may have implications for treatment of patients with activated protein C
medicine
pharmacology