3.1.6.13: iduronate-2-sulfatase

This is an abbreviated version!
For detailed information about iduronate-2-sulfatase, go to the full flat file.

Word Map on EC 3.1.6.13

3.1.6.13

mucopolysaccharidosis

lysosomal

glycosaminoglycans

x-linked

dermatan

heparan

multisystemic

sulfatases

hepatosplenomegaly

medicine

arylsulfatase

mpsii

x-chromosome

enzyme-replacement

analysis

synthesis

alpha-l-iduronidase

neuronopathic

infusion-related

drug development

6-minute

dysostosis

diagnostics

shire

hurler

Reaction

Synonyms

2-sulfo-L-iduronate 2-sulfatase, chondroitinsulfatase, elaprase, Hunter corrective factor, I2S, IDS, IDS-Like, IDS-like enzyme, iduronate 2-sulfatase, iduronate 2-sulfate sulfatase-like, iduronate 2-sulfate-like enzyme, iduronate sulfatase, iduronate sulfate sulfatase, iduronate-2-sulfatase, iduronate-2-sulfate sulfatase, iduronate-2-sulphatase, iduronide-2-sulfate sulfatase, idurono-2-sulfatase, idursulfase, L-iduronate 2-sulfate sulfatase, L-idurono sulfate sulfatase, sulfatase, L-idurono-, sulfo-L-iduronate sulfatase, sulfoiduronate sulfohydrolase

ECTree

3 Hydrolases

3.1 Acting on ester bonds

3.1.6 Sulfuric-ester hydrolases

3.1.6.13 iduronate-2-sulfatase

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Results	in table
1	Activating Compound
91	AA Sequence
32	Application
1	CAS Registry Number
22	Cloned(Commentary)
2	Crystallization (Commentary)
1431	Disease/ Diagnostics
8	Expression
15	General Information
3	General Stability
37	Inhibitors
17	KM Value [mM]
20	Localization
2	Metals/Ions
25	Molecular Weight [Da]
47	Natural Substrates/ Products (Substrates)
52	Organism
3	Pathway
2	PDB ID
9	pH Optimum
3	pH Stability
1	pI Value
8	Posttranslational Modification
46	Protein Variants
10	Purification (Commentary)
1	Reaction
1	Reaction Type
52	Reference
68	Source Tissue
10	Specific Activity [micromol/min/mg]
4	Storage Stability
83	Substrates and Products (Substrate)
10	Subunits
51	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
6	Temperature Stability [°C]

Specific Activity

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Specific Activity on EC 3.1.6.13 - iduronate-2-sulfatase

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0.000006 - 0.00066

Homo sapiens

hrIDS detection by ELISA-sandwich and fluorometric assay in Pichia pastoris culture samples, substrate is 4-methylumbelliferyl-2-iduronate-2-sulfate, pH not specified in the publication, temperature not specified in the publication, overview

715792

0.00063 - 0.0021

Homo sapiens

enzyme determination in human plasma samples by a Fluorometric method, and ELISA double sandwich technique after several freeze and thawing cycles, substrate is 4-methylumbelliferyl-2-iduronate-2-sulfate, pH not specified in the publication, temperature not specified in the publication, overview

0.00083

0.006

untreated neuronal cells, comparison to cells after adenoviral infection

650371

0.00725

Rattus norvegicus

untreated control cells, comparison to cells after adenoviral infection

650371

0.21

Homo sapiens

P22304

recombinant protein, pH not specified in the publication, temperature not specified in the publication

0.6

20°C, pH 5.0

11.9

20.8

recombinant protein

78 - 94

pH 5.0, 37°C