3.1.6.13: iduronate-2-sulfatase

This is an abbreviated version!
For detailed information about iduronate-2-sulfatase, go to the full flat file.

Word Map on EC 3.1.6.13

3.1.6.13

mucopolysaccharidosis

lysosomal

glycosaminoglycans

x-linked

dermatan

heparan

multisystemic

sulfatases

hepatosplenomegaly

medicine

arylsulfatase

mpsii

x-chromosome

enzyme-replacement

analysis

synthesis

alpha-l-iduronidase

neuronopathic

infusion-related

drug development

6-minute

dysostosis

diagnostics

shire

hurler

Reaction

Synonyms

2-sulfo-L-iduronate 2-sulfatase, chondroitinsulfatase, elaprase, Hunter corrective factor, I2S, IDS, IDS-Like, IDS-like enzyme, iduronate 2-sulfatase, iduronate 2-sulfate sulfatase-like, iduronate 2-sulfate-like enzyme, iduronate sulfatase, iduronate sulfate sulfatase, iduronate-2-sulfatase, iduronate-2-sulfate sulfatase, iduronate-2-sulphatase, iduronide-2-sulfate sulfatase, idurono-2-sulfatase, idursulfase, L-iduronate 2-sulfate sulfatase, L-idurono sulfate sulfatase, sulfatase, L-idurono-, sulfo-L-iduronate sulfatase, sulfoiduronate sulfohydrolase

ECTree

3 Hydrolases

3.1 Acting on ester bonds

3.1.6 Sulfuric-ester hydrolases

3.1.6.13 iduronate-2-sulfatase

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Results	in table
1	Activating Compound
91	AA Sequence
32	Application
1	CAS Registry Number
22	Cloned(Commentary)
2	Crystallization (Commentary)
1431	Disease/ Diagnostics
8	Expression
15	General Information
3	General Stability
37	Inhibitors
17	KM Value [mM]
20	Localization
2	Metals/Ions
25	Molecular Weight [Da]
47	Natural Substrates/ Products (Substrates)
52	Organism
3	Pathway
2	PDB ID
9	pH Optimum
3	pH Stability
1	pI Value
8	Posttranslational Modification
46	Protein Variants
10	Purification (Commentary)
1	Reaction
1	Reaction Type
52	Reference
68	Source Tissue
10	Specific Activity [micromol/min/mg]
4	Storage Stability
83	Substrates and Products (Substrate)
10	Subunits
51	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
6	Temperature Stability [°C]

KM Value

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KM Value on EC 3.1.6.13 - iduronate-2-sulfatase

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0.0192

O-(alpha-L-idopyranosyluronic acid 2-sulfate)-(1-4)-2,5-anhydro-D-mannitol

Homo sapiens

135575

0.0025 - 0.043

O-(alpha-L-idopyranosyluronic acid 2-sulfate)-(1-4)-2,5-anhydro-D-mannitol 6-sulfate

8 entries

0.133 - 0.327

O-(alpha-L-idopyranosyluronic acid-2-sulfate)-(1-4)-2,5 anhydromannose-6-sulfate

2 entries

0.0007 - 0.0011

O-(alpha-L-iduronic acid 2-sulfate)-(1-3)-2,5-anhydro-D-talitol 4-sulfate

Homo sapiens

pH dependent

135575

0.0014

O-(alpha-L-iduronic acid 2-sulfate)-(1-4)-D-O-(alpha 2-sulfaminoglucosamine 6-sulfate)-(1-4)-L-O-(alpha-L-iduronic acid 2-sulfate)-D-O-2,5-anhydro-mannitol 6-sulfate

Homo sapiens

pH dependent

135575

0.0019

O-(alpha-L-iduronic acid 2-sulfate)-(1-4)-D-O-(alpha 2-sulfaminoglucosamine 6-sulfate)-(1-4)-O-(beta-D-glucuronic acid or L-iduronic acid)-(1-4)-D-O-(alpha-N-acetylglucosamine)-(1-3)-D-O-gulonic acid

Homo sapiens

pH dependent

135575

0.0025

O-(alpha-L-iduronic acid 2-sulfate)-(1-4)-D-O-(alpha glucosamine 6-sulfate)-(1-4)-L-O-(alpha-L-iduronic acid 2-sulfate)-D-O-2,5-anhydro-mannitol 6-sulfate

Homo sapiens

pH dependent

135575

0.0031

O-(alpha-L-iduronic acid 2-sulfate)-(1-4)-D-O-(alpha-N-acetylglucosamine 6-sulfate)-(1-4)-L-O-(alpha-L-iduronic acid 2-sulfate)-D-O-2,5-anhydro-mannitol 6-sulfate

Homo sapiens

pH dependent

135575

0.01 - 0.02

sulfoiduronyl sulfoanhydromannitol

Homo sapiens

135567