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3.1.6.13: iduronate-2-sulfatase

This is an abbreviated version!
For detailed information about iduronate-2-sulfatase, go to the full flat file.

Word Map on EC 3.1.6.13

Reaction

L-iduronate-2-sulfate
+
H2O
=
L-iduronate
 +
sulfate

Synonyms

2-sulfo-L-iduronate 2-sulfatase, chondroitinsulfatase, elaprase, Hunter corrective factor, I2S, IDS, IDS-Like, IDS-like enzyme, iduronate 2-sulfatase, iduronate 2-sulfate sulfatase-like, iduronate 2-sulfate-like enzyme, iduronate sulfatase, iduronate sulfate sulfatase, iduronate-2-sulfatase, iduronate-2-sulfate sulfatase, iduronate-2-sulphatase, iduronide-2-sulfate sulfatase, idurono-2-sulfatase, idursulfase, L-iduronate 2-sulfate sulfatase, L-idurono sulfate sulfatase, sulfatase, L-idurono-, sulfo-L-iduronate sulfatase, sulfoiduronate sulfohydrolase

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.6 Sulfuric-ester hydrolases
                3.1.6.13 iduronate-2-sulfatase

Expression

Expression on EC 3.1.6.13 - iduronate-2-sulfatase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
although IDS transcript levels are reduced (51-71% normal) in Hunter syndrome patients, some wild-type IDS protein is detectable
-
IDS expression in the liver and lungs of the control (wild-type and idsy/-) or treated (after 1 month or 18 months of AAV2/5CMV-hIDS therapy) mice
-
IDS expression restrictedly observed in human pancreatic islet
-
IDS is abundantly expressed during early developmental stages, IDS mRNAs is present already at the two-cell stage, pointing to a maternal origin of the transcripts. At later stages, ubiquitous expression from shield to 24 hours post fertilization. At 24 hours post fertilization a visible increased concentration of transcripts detectable in the head, particularly in the region surrounding the midbrain-hindbrain boundary. From the hatching phase (48 hours post fertilization), restriction of IDS transcription to the head, with a more intense staining in the retina, otic vesicles, the tectum and the vascular mesenchyme. More caudally, expression in the liver and pectoral fin buds. At 72 hours post fertilization IDS transcripts mainly present in two distinct areas, corresponding to the splanchnocranium and the gut, and a faint staining still in the otic vesicle. This expression pattern becomes more defined at 120 hours post fertilization, when the intensity of the hybridization signal in the gut and splanchnocranium. In the adult stage, IDS mRNAs in all the examined tissues
IDS-Like expression is induced by methanol addition
-
knocking down with antisense morpholino oligos, significant decrease in the enzymatic activity after 24 hours post-morpholino injection in morphants (72.3% of the control). Inability of the morpholino to completely suppress the IDS activity due to maternally derived enzyme. Increased transforming growth factor beta signalling is tightly associated with downregulation of iduronate sulfatase function
no IDS expression in the brain samples of the control (wild-type and idsy/-) or treated (after 1 month or 18 months of AAV2/5CMV-hIDS therapy) mice
-
presence of wild-type IDS mRNA-transcripts in Hunter syndrome patients, but no wild-type IDS genomic sequence detectable
-