3.1.1.52: phosphatidylinositol deacylase

This is an abbreviated version!
For detailed information about phosphatidylinositol deacylase, go to the full flat file.

Reaction

Synonyms

cPLA2alpha, group IVA cytosolic phospholipase A2alpha, phosphatidylinositol phospholipase A2, phospholipase A2, phosphatidylinositol

ECTree

     3 Hydrolases

         3.1 Acting on ester bonds

             3.1.1 Carboxylic-ester hydrolases

                3.1.1.52 phosphatidylinositol deacylase

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Results	in table
4	Activating Compound
1	CAS Registry Number
1	Cloned(Commentary)
1	General Stability
5	Inhibitors
1	KM Value [mM]
4	Localization
3	Metals/Ions
3	Molecular Weight [Da]
1	Natural Substrates/ Products (Substrates)
5	Organism
1	Pathway
1	pH Optimum
1	pH Range
1	Posttranslational Modification
9	Protein Variants
2	Purification (Commentary)
1	Reaction
1	Reaction Type
5	Reference
5	Source Tissue
13	Specific Activity [micromol/min/mg]
12	Substrates and Products (Substrate)
1	Subunits
4	Synonyms
1	Systematic Name
1	Temperature Stability [°C]

Specific Activity

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Specific Activity on EC 3.1.1.52 - phosphatidylinositol deacylase

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SPECIFIC ACTIVITY [µmol/min/mg]

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

0.21

Mus musculus

-

mutant K271N/K273N/K274N, from activated platelets

693262

0.23

Mus musculus

-

wild-type, from activated platelets

693262

0.26

Mus musculus

-

phoshorylated at residue S515, from activated platelets

693262

0.38

Mus musculus

-

phoshorylated at residue S505, from activated platelets

693262

0.39

Mus musculus

-

mutant K488N/K543N/K544N, from activated platelets, in presence of 10 mol% phosphatidylinositol 4,5-biphosphate

693262

0.4

Mus musculus

-

mutant K488N/K543N/K544N, from activated platelets

693262

0.405

Mus musculus

-

phosphorylated at residues S505 and S727, from activated platelets

693262

0.68

Mus musculus

-

mutant K271N/K273N/K274N, from activated platelets, in presence of 10 mol% phosphatidylinositol 4,5-biphosphate

693262

0.742

Bos taurus

-

-

80966

0.866

Mus musculus

-

phoshorylated at residue S515, from activated platelets, in presence of 10 mol% phosphatidylinositol 4,5-biphosphate

693262

1.03

Mus musculus

-

wild-type, from activated platelets, in presence of 10 mol% phosphatidylinositol 4,5-biphosphate

693262

1.45

Mus musculus

-

phoshorylated at residue S505, from activated platelets, in presence of 10 mol% phosphatidylinositol 4,5-biphosphate

693262

additional information

Mus musculus

-

5fold increase in specific activity of activated platelet-derived wild-type and phosphorylated forms in presence of 10 mol% phosphatidylinositol 4,5-biphosphate

693262