3.1.1.52: phosphatidylinositol deacylase

This is an abbreviated version!
For detailed information about phosphatidylinositol deacylase, go to the full flat file.

Word Map on EC 3.1.1.52

Reaction

1-phosphatidyl-D-myo-inositol
+
H2O
=
1-acylglycerophosphoinositol
+
a carboxylate

Synonyms

phosphatidylinositol phospholipase A2, phospholipase A2, phosphatidylinositol, cPLA2alpha, group IVA cytosolic phospholipase A2alpha

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.1 Carboxylic-ester hydrolases
                3.1.1.52 phosphatidylinositol deacylase

Specific Activity

Specific Activity on EC 3.1.1.52 - phosphatidylinositol deacylase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.21
-
mutant K271N/K273N/K274N, from activated platelets
0.23
-
wild-type, from activated platelets
0.26
-
phoshorylated at residue S515, from activated platelets
0.38
-
phoshorylated at residue S505, from activated platelets
0.39
-
mutant K488N/K543N/K544N, from activated platelets, in presence of 10 mol% phosphatidylinositol 4,5-biphosphate
0.4
-
mutant K488N/K543N/K544N, from activated platelets
0.405
-
phosphorylated at residues S505 and S727, from activated platelets
0.68
-
mutant K271N/K273N/K274N, from activated platelets, in presence of 10 mol% phosphatidylinositol 4,5-biphosphate
0.742
-
-
0.866
-
phoshorylated at residue S515, from activated platelets, in presence of 10 mol% phosphatidylinositol 4,5-biphosphate
1.03
-
wild-type, from activated platelets, in presence of 10 mol% phosphatidylinositol 4,5-biphosphate
1.45
-
phoshorylated at residue S505, from activated platelets, in presence of 10 mol% phosphatidylinositol 4,5-biphosphate
additional information
-
5fold increase in specific activity of activated platelet-derived wild-type and phosphorylated forms in presence of 10 mol% phosphatidylinositol 4,5-biphosphate