3.1.1.52: phosphatidylinositol deacylase
This is an abbreviated version!
For detailed information about phosphatidylinositol deacylase, go to the full flat file.
Word Map on EC 3.1.1.52
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3.1.1.52
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arachidonic
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prostaglandin
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eicosanoids
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leukotrienes
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spla2s
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platelet-activating
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pyrrophenone
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cpla2gamma
- 3.1.1.52
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arachidonic
- prostaglandin
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eicosanoids
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leukotrienes
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spla2s
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platelet-activating
- pyrrophenone
- cpla2gamma
Reaction
Synonyms
cPLA2alpha, group IVA cytosolic phospholipase A2alpha, phosphatidylinositol phospholipase A2, phospholipase A2, phosphatidylinositol
ECTree
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Activating Compound
Activating Compound on EC 3.1.1.52 - phosphatidylinositol deacylase
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phorbol myristate acetate
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PMA, 100 nM to cells induces translocation (maximum after 15 min) of enzyme to the Golgi apparatus and release of 4-5% of cell-associated arachidonic acid within 80 min, effect impaired by PKC inhibition and block of protein synthesis
serum
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10% mouse serum to cells induces immediate translocation (within 60 seconds) of enzyme to the Golgi apparatus and release of 20% of cell-associated arachidonic acid within 80 min, effect depends on ERK and p38/MAPK pathway activation and calcium binding, effect is impaired by block of protein synthesis
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