1.8.4.B3: thioredoxin-independent methionine sulfoxide reductases B
This is an abbreviated version!
For detailed information about thioredoxin-independent methionine sulfoxide reductases B, go to the full flat file.
Reaction
Synonyms
hMsrB2, hMsrB3, NtMsrB1, thioredoxin-independent methionine sulfoxide reductases B
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Substrates Products
Substrates Products on EC 1.8.4.B3 - thioredoxin-independent methionine sulfoxide reductases B
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REACTION DIAGRAM
dabsyl-L-methionine (R)-S-sulfoxide + bovine liver thionein
dabsyl-L-methionine + bovine liver thionein + H2O
NtMsrB1
-
-
?
dabsyl-L-methionine (R)-S-sulfoxide + dithiothreitol
dabsyl-L-methionine + dithiothreitol disulfide + H2O
NtMsrB1
-
-
?
dabsyl-L-methionine (R)-S-sulfoxide + plant Trx-like protein CDSP32
dabsyl-L-methionine + ?
NtMsrB1
-
-
?
dabsyl-L-methionine (R)-S-sulfoxide + selenocysteamine
dabsyl-L-methionine + 2,2'-disulfanediyldiethanamine + H2O
NtMsrB1
-
-
?
L-methionine (R)-S-sulfoxide + dithiothreitol
L-methionine + dithiothreitol disulfide + H2O
-
-
-
?
L-methionine (R)-S-sulfoxide + thionein
L-methionine + thionein disulfide + H2O
-
-
-
?
L-methionine (R)-S-sulfoxide + thioredoxin
L-methionine + thioredoxin disulfide
reduced thioredoxin is not an efficient reducing agent for hMsrB3. Less than 5% of the activity with dithiothreitol
-
-
?
L-methionine (R)-S-sulfoxide + thioredoxin
L-methionine + thioredoxin disulfide + H2O
reduced thioredoxin is not an efficient reducing agent for hMsrB2. Less than 5% of the activity with dithiothreitol
-
-
?
L-methionine (R)-sulfoxide + dithiothreitol
L-methionine + dithiothreitol disulfide
-
-
-
?
peptide-L-methionine-(R)-S-sulfoxide + thionein
peptide-L-methionine + thionein disulfide + H2O
-
-
-
?
?
-
zinc-containing metallothionein in the presence of EDTA can serve as a reducing agent. Thioredoxin can reduce oxidized thionein
-
-
?
additional information
?
-
zinc-containing metallothionein in the presence of EDTA can serve as a reducing agent. Thioredoxin can reduce oxidized thionein
-
-
?
additional information
?
-
-
zinc-containing metallothionein in the presence of EDTA can serve as a reducing agent. Thioredoxin can reduce oxidized thionein
-
-
?
additional information
?
-
NtMsrB1 shows very little activity towards L-methionine (R)-sulfoxide. Escherichia coli thioredoxin can not serve as a reducing agent for NtMsrB1. The Trx-independent MsrB enzyme lacks an additional cysteine (resolving cysteine) that is capable of forming a disulfide bond on the enzyme during the catalytic reaction
-
-
?
additional information
?
-
-
NtMsrB1 shows very little activity towards L-methionine (R)-sulfoxide. Escherichia coli thioredoxin can not serve as a reducing agent for NtMsrB1. The Trx-independent MsrB enzyme lacks an additional cysteine (resolving cysteine) that is capable of forming a disulfide bond on the enzyme during the catalytic reaction
-
-
?