BRENDA - Enzyme Database show
show all sequences of 1.8.4.B3

Thionein can serve as a reducing agent for the methionine sulfoxide reductases

Sagher, D.; Brunell, D.; Hejtmancik, J.F.; Kantorow, M.; Brot, N.; Weissbach, H.; Proc. Natl. Acad. Sci. USA 103, 8656-8661 (2006)

Data extracted from this reference:

Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
Q8IXL7
-
-
Homo sapiens
Q9Y3D2
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
L-methionine (R)-S-sulfoxide + dithiothreitol
-
670705
Homo sapiens
L-methionine + dithiothreitol disulfide + H2O
-
-
-
?
L-methionine (R)-S-sulfoxide + thionein
-
670705
Homo sapiens
L-methionine + thionein disulfide + H2O
-
-
-
?
L-methionine (R)-S-sulfoxide + thioredoxin
reduced thioredoxin is not an efficient reducing agent for hMsrB3. Less than 5% of the activity with dithiothreitol
670705
Homo sapiens
L-methionine + thioredoxin disulfide
-
-
-
?
L-methionine (R)-S-sulfoxide + thioredoxin
reduced thioredoxin is not an efficient reducing agent for hMsrB2. Less than 5% of the activity with dithiothreitol
670705
Homo sapiens
L-methionine + thioredoxin disulfide + H2O
-
-
-
?
L-methionine (R)-sulfoxide + dithiothreitol
-
670705
Homo sapiens
L-methionine + dithiothreitol disulfide
-
-
-
?
additional information
zinc-containing metallothionein in the presence of EDTA can serve as a reducing agent. Thioredoxin can reduce oxidized thionein
670705
Homo sapiens
?
-
-
-
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
L-methionine (R)-S-sulfoxide + dithiothreitol
-
670705
Homo sapiens
L-methionine + dithiothreitol disulfide + H2O
-
-
-
?
L-methionine (R)-S-sulfoxide + thionein
-
670705
Homo sapiens
L-methionine + thionein disulfide + H2O
-
-
-
?
L-methionine (R)-S-sulfoxide + thioredoxin
reduced thioredoxin is not an efficient reducing agent for hMsrB3. Less than 5% of the activity with dithiothreitol
670705
Homo sapiens
L-methionine + thioredoxin disulfide
-
-
-
?
L-methionine (R)-S-sulfoxide + thioredoxin
reduced thioredoxin is not an efficient reducing agent for hMsrB2. Less than 5% of the activity with dithiothreitol
670705
Homo sapiens
L-methionine + thioredoxin disulfide + H2O
-
-
-
?
L-methionine (R)-sulfoxide + dithiothreitol
-
670705
Homo sapiens
L-methionine + dithiothreitol disulfide
-
-
-
?
additional information
zinc-containing metallothionein in the presence of EDTA can serve as a reducing agent. Thioredoxin can reduce oxidized thionein
670705
Homo sapiens
?
-
-
-
-
Other publictions for EC 1.8.4.B3
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
684867
Ding
Studies on the reducing system ...
Nicotiana tabacum
Biochem. Biophys. Res. Commun.
361
629-633
2007
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670705
Sagher
Thionein can serve as a reduci ...
Homo sapiens
Proc. Natl. Acad. Sci. USA
103
8656-8661
2006
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