1.5.5.2: proline dehydrogenase

This is an abbreviated version!
For detailed information about proline dehydrogenase, go to the full flat file.

Word Map on EC 1.5.5.2

Reaction

L-proline
+
a quinone
=
(S)-1-pyrroline-5-carboxylate
+
a quinol

Synonyms

bifunctional dye-linked L-proline/NADH dehydrogenase complex, dye-linked L-proline dehydrogenase, FAD-dependent L-proline oxidoreductase, JcProDH, L-proline dehydrogenase, L-proline:FAD oxidoreductase, PdhB, PDHbeta, PF1246, PF1798, PH1364, PH1751, PRODH, proDH-B1, proDH-B2, PRODH/POX, ProDH1, proline dehydrogenase, proline dehydrogenase 1, proline dehydrogenase/oxidase, proline oxidase, proline/P5C dehydrogenase, prub, PutA, PutA flavoprotein, PutA proline dehydrogenase, Tc00.1047053506411.30, TcPRODH, TK0117, TK0122, TPpdhbeta, TtProDH

ECTree

     1 Oxidoreductases
         1.5 Acting on the CH-NH group of donors
             1.5.5 With a quinone or similar compound as acceptor
                1.5.5.2 proline dehydrogenase

Inhibitors

Inhibitors on EC 1.5.5.2 - proline dehydrogenase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-Thenoyltrifluoroacetone
5-ethylpentyl-barbituric acid
-
membrane-associated enzyme, not soluble enzyme
acetate
competitive
antimycin A
cyanide
-
only membrane-associated enzyme, not soluble enzyme
D-lactate
GuHCl
-
enzyme unfolding at 1 M, 0.5 M is not enough for proper unfolding. The fusion protein forms visible aggregates due to unfolding of MBP
L-Azetidine-2-carboxylate
-
competitive
L-lactate
L-proline
L-tetrahydro-2-furoic acid
L-thiazolidine-4-carboxylate
-
competitive
Lactate
-
-
N-propargylglycine
-
irreversibly inactivates PutA by covalently linking the flavin N(5) atom to the epsilon-amino of Lys329. Inactivation locks PutA into a conformation that may mimic the proline-reduced, membrane-associated form
pyrrolidone-5-carboxylate
pyruvate
-
-
rotenone
succinate
additional information
-