1.5.5.2: proline dehydrogenase

This is an abbreviated version!
For detailed information about proline dehydrogenase, go to the full flat file.

Reaction

Synonyms

bifunctional dye-linked L-proline/NADH dehydrogenase complex, dye-linked L-proline dehydrogenase, FAD-dependent L-proline oxidoreductase, JcProDH, L-proline dehydrogenase, L-proline:FAD oxidoreductase, PdhB, PDHbeta, PF1246, PF1798, PH1364, PH1751, PRODH, proDH-B1, proDH-B2, PRODH/POX, ProDH1, proline dehydrogenase, proline dehydrogenase 1, proline dehydrogenase/oxidase, proline oxidase, proline/P5C dehydrogenase, prub, PutA, PutA flavoprotein, PutA proline dehydrogenase, Tc00.1047053506411.30, TcPRODH, TK0117, TK0122, TPpdhbeta, TtProDH

ECTree

     1 Oxidoreductases

         1.5 Acting on the CH-NH group of donors

             1.5.5 With a quinone or similar compound as acceptor

                1.5.5.2 proline dehydrogenase

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Results

in table

25901

AA Sequence

2

Application

1

CAS Registry Number

17

Cloned(Commentary)

28

Cofactor

6

Crystallization (Commentary)

167

Disease/ Diagnostics

19

Engineering

9

Expression

35

General Information

1

General Stability

36

Inhibitors

26

KCat/KM [mM/s]

10

Ki Value [mM]

33

KM Value [mM]

11

Localization

1

Metals/Ions

19

Molecular Weight [Da]

14

Natural Substrates/ Products (Substrates)

49

Organism

10

Pathway

59

PDB ID

13

pH Optimum

1

pH Range

2

pH Stability

1

pI Value

17

Purification (Commentary)

2

Reaction

3

Reaction Type

41

Reference

8

Source Tissue

9

Specific Activity [micromol/min/mg]

65

Substrates and Products (Substrate)

31

Subunits

87

Synonyms

1

Systematic Name

12

Temperature Optimum [°C]

1

Temperature Range [°C]

14

Temperature Stability [°C]

23

Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 1.5.5.2 - proline dehydrogenase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

L-proline + a quinone

(S)-1-pyrroline-5-carboxylate + a quinol

6 entries

L-proline + acceptor

(S)-1-pyrroline-5-carboxylate + reduced acceptor

2 entries

L-proline + acceptor + H2O

(S)-1-pyrroline-5-carboxylate + reduced acceptor

5 entries

L-proline + oxidized phenazine methosulfate

(S)-1-pyrroline-5-carboxylate + reduced phenazine methosulfate

Arabidopsis thaliana

-

-

742487

-

-

?

L-proline + a quinone

(S)-1-pyrroline-5-carboxylate + a quinol

Thermus thermophilus

Q72IB8

-

742162

-

-

?

L-proline + a quinone

(S)-1-pyrroline-5-carboxylate + a quinol

Thermus thermophilus

Q72IB8

the reverse reaction is catalyzed by pyrroline-5-carboxylate reductase, EC 1.5.1.2

743834

-

-

ir

L-proline + a quinone

(S)-1-pyrroline-5-carboxylate + a quinol

Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039

Q72IB8

-

742162

-

-

?

L-proline + a quinone

(S)-1-pyrroline-5-carboxylate + a quinol

Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039

Q72IB8

the reverse reaction is catalyzed by pyrroline-5-carboxylate reductase, EC 1.5.1.2

743834

-

-

ir

L-proline + a quinone

(S)-1-pyrroline-5-carboxylate + a quinol

Trypanosoma cruzi

Q4CVA1

the reverse reaction is catalyzed by pyrroline-5-carboxylate reductase, EC 1.5.1.2

743635

-

-

ir

L-proline + a quinone

(S)-1-pyrroline-5-carboxylate + a quinol

Trypanosoma cruzi CL Brener

Q4CVA1

the reverse reaction is catalyzed by pyrroline-5-carboxylate reductase, EC 1.5.1.2

743635

-

-

ir

L-proline + acceptor

(S)-1-pyrroline-5-carboxylate + reduced acceptor

Escherichia coli

P09546

the bifunctional enzyme catalyzes the oxidation of proline in two steps. (S)-1-Pyrroline-5-carboxylate, the product of the first reaction is in spontaneous equilibrium with its tautomer L-glutamate gamma-semialdehyde: (1) L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor, (2) L-glutamate 5-semialdehyde + NAD+ + H2O = L-glutamate + NADH + H+

722591

-

-

?

L-proline + acceptor

(S)-1-pyrroline-5-carboxylate + reduced acceptor

Pyrococcus horikoshii

O59088; O59089

-

739932

-

-

?

L-proline + acceptor + H2O

(S)-1-pyrroline-5-carboxylate + reduced acceptor

Escherichia coli

-

-

392555

-

392555

?

L-proline + acceptor + H2O

(S)-1-pyrroline-5-carboxylate + reduced acceptor

Escherichia coli

-

-

392556

-

392556

?

L-proline + acceptor + H2O

(S)-1-pyrroline-5-carboxylate + reduced acceptor

Escherichia coli

-

-

392560

-

392560

?

L-proline + acceptor + H2O

(S)-1-pyrroline-5-carboxylate + reduced acceptor

Escherichia coli

P09546

PutA flavoprotein plays multiple roles in proline catabolism by functioning as a membrane-associated bi-functional enzyme and a transcriptional repressor of proline utilization genes

659987

-

-

?

L-proline + acceptor + H2O

(S)-1-pyrroline-5-carboxylate + reduced acceptor

Escherichia coli

P09546

the enzyme catalyzes the first step of proline catabolism

658033

-

-

?