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1.2.1.50: long-chain acyl-protein thioester reductase

This is an abbreviated version!
For detailed information about long-chain acyl-protein thioester reductase, go to the full flat file.

Word Map on EC 1.2.1.50

Reaction

a long-chain aldehyde
+
[protein]-L-cysteine
 +
NADP+
=
a [protein]-S-(long-chain fatty acyl)-L-cysteine
 +
NADPH
 +
H+

Synonyms

acyl coenzyme A reductase, acyl-CoA reductase, AmFAR1, CER4, CpFAS1-R, FACoAR, FAR1, FAR2, FAR3, FAR6, FAR8, fatty acyl-CoA reductase, fatty acyl-CoA reductase 1, fatty acyl-CoA reductase 2, fatty acyl-CoA reductase 3, fatty acyl-CoA reductase 6, fatty acyl-CoA reductase 8, long-chain-fatty-acyl-CoA reductase

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.1 With NAD+ or NADP+ as acceptor
                1.2.1.50 long-chain acyl-protein thioester reductase

Molecular Weight

Molecular Weight on EC 1.2.1.50 - long-chain acyl-protein thioester reductase

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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
116000
Marinobacter nauticus
-
SDS-PAGE, in agreement with mass calculated from amino acid sequence
140000
-
recombinant CpFAS1-R domain as maltose binding protein fusion protein, SDS-PAGE
205000 - 223000
-
reductase component of fatty acid reductase enzyme complex, gel filtration, SDS-PAGE after cross-linkage with bis(sulfosuccinimidyl)suberate
33000
x * 33000, SDS-PAGE
34000
450000
-
fatty acid reductase enzyme complex composed of synthetase (s), reductase (r) and transferase (t), molar ratio s: r: t is 1: 1: 0.5, gel filtration
50000
-
x * 58000 + x * 34000 + x * 50000, reductase, transferase and synthetase subunit of the enzyme complex, SDS-PAGE
51000
theoretical value, verified by SDS-PAGE
52000
-
x * 57000 + x * 34000 + x * 52000, reductase, transferase and synthetase subunit of the enzyme complex, SDS-PAGE
55500
theoretical value, verified by SDS-PAGE
56000
56200
-
x * 56200, SDS-PAGE
57000
-
x * 57000 + x * 34000 + x * 52000, reductase, transferase and synthetase subunit of the enzyme complex, SDS-PAGE
58000
-
x * 58000 + x * 34000 + x * 50000, reductase, transferase and synthetase subunit of the enzyme complex, SDS-PAGE
59200
calculated from sequence
61600
theoretical value, verified by SDS-PAGE
68400
theoretical value, verified by SDS-PAGE, heavily degraded