1.2.1.50: long-chain acyl-protein thioester reductase

This is an abbreviated version!
For detailed information about long-chain acyl-protein thioester reductase, go to the full flat file.

Word Map on EC 1.2.1.50

Reaction

a long-chain aldehyde
+
[protein]-L-cysteine
+
NADP+
=
a [protein]-S-(long-chain fatty acyl)-L-cysteine
+
NADPH
+
H+

Synonyms

acyl coenzyme A reductase, acyl-CoA reductase, AmFAR1, CER4, CpFAS1-R, FACoAR, FAR1, FAR2, FAR3, FAR6, FAR8, fatty acyl-CoA reductase, fatty acyl-CoA reductase 1, fatty acyl-CoA reductase 2, fatty acyl-CoA reductase 3, fatty acyl-CoA reductase 6, fatty acyl-CoA reductase 8, long-chain-fatty-acyl-CoA reductase

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.1 With NAD+ or NADP+ as acceptor
                1.2.1.50 long-chain acyl-protein thioester reductase

Systematic Name

Systematic Name on EC 1.2.1.50 - long-chain acyl-protein thioester reductase

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SYSTEMATIC NAME
IUBMB Comments
long-chain-aldehyde:NADP+ oxidoreductase (protein thioesther-forming)
Together with a hydrolase component (EC 3.1.2.2 and EC 3.1.2.14) and a synthetase component (EC 6.2.1.19), this enzyme forms a multienzyme fatty acid reductase complex that produces the long-chain aldehyde substrate of the bacterial luciferase enzyme (EC 1.14.14.3). The enzyme is acylated by receiving an acyl group from EC 6.2.1.19, and catalyses the reduction of the acyl group, releasing the aldehyde product. The enzyme is also able to accept the acyl group from a long-chain acyl-CoA.