1.2.1.50: long-chain acyl-protein thioester reductase

This is an abbreviated version!
For detailed information about long-chain acyl-protein thioester reductase, go to the full flat file.

Word Map on EC 1.2.1.50

Reaction

a long-chain aldehyde
+
[protein]-L-cysteine
+
NADP+
=
a [protein]-S-(long-chain fatty acyl)-L-cysteine
+
NADPH
+
H+

Synonyms

acyl coenzyme A reductase, acyl-CoA reductase, AmFAR1, CER4, CpFAS1-R, FACoAR, FAR1, FAR2, FAR3, FAR6, FAR8, fatty acyl-CoA reductase, fatty acyl-CoA reductase 1, fatty acyl-CoA reductase 2, fatty acyl-CoA reductase 3, fatty acyl-CoA reductase 6, fatty acyl-CoA reductase 8, long-chain-fatty-acyl-CoA reductase

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.1 With NAD+ or NADP+ as acceptor
                1.2.1.50 long-chain acyl-protein thioester reductase

Substrates Products

Substrates Products on EC 1.2.1.50 - long-chain acyl-protein thioester reductase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
a long-chain acyl-CoA + NADPH + H+
a long-chain aldehyde + CoA + NADP+
show the reaction diagram
-
-
-
-
?
a long-chain fatty acyl-CoA + NADPH + H+
a long-chain aldehyde + CoA + NADP+
show the reaction diagram
AmFAR1 converts saturated fatty acids ranging from 16 to 22 carbon chains to their corresponding alcohols with the highest conversion efficiency shown on 18:0, AmFAR1 also shows some activities on ricinoleic acid, 16:1n-7 and 18:1n-9
aldehyde intermediate is immediately reduced to the corresponding alcohol
-
?
arachidonoyl-CoA + NADPH + H+
(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenal + CoA + NADP+
show the reaction diagram
-
-
further reduction of (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenal into the corresponding (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraen-1-ol
-
-
arachidoyl-CoA + NADP+
eicosanal + CoA + NADPH
show the reaction diagram
erucoyl-CoA + NADPH + H+
(13Z)-docos-13-enal + CoA + NADP+
show the reaction diagram
-
erucoyl-CoA i.e. (13Z)-docos-13-enoyl-CoA
further direct reduction of (13Z)-docos-13-enal into the corresponding (13Z)-docos-13-en-1-ol
-
?
fatty acyl-CoA + NADPH + H+
fatty aldehyde + CoA + NADP+
show the reaction diagram
-
-
reaction intermediate, enzyme converts fatty acyl-CoA directly into the corresponding fatty alcohol by four-electron reduction, free fatty aldehyde intermediate is not accessible
-
-
hexadecanoyl-CoA + NADPH
hexadecanal + CoA + NADP+
show the reaction diagram
-
-
-
-
?
icosanoyl-CoA + NADPH + H+
icosanal + CoA + NADP+
show the reaction diagram
-
-
further direct reduction of icosanal into the corresponding icosan-1-ol
-
?
lauroyl-CoA + NADP+
dodecanal + CoA + NADPH
show the reaction diagram
lauroyl-CoA + NADPH + H+
dodecanal + CoA + NADP+
show the reaction diagram
-
-
further reduction of dodecanal into the corresponding dodecan-1-ol
-
-
myristoyl-CoA + NADP+
? + CoA + NADPH
show the reaction diagram
myristoyl-CoA + NADPH
?
show the reaction diagram
-
-
-
-
?
myristoyl-CoA + NADPH + H+
tetradecanal + CoA + NADP+
show the reaction diagram
-
-
further reduction of tetradecanal into the corresponding tetradecan-1-ol
-
-
octanoyl-CoA + NADPH + H+
octanal + NADP+
show the reaction diagram
-
-
further reduction of octanal into the corresponding octan-1-ol
-
-
oleoyl-CoA + NADPH + H+
(9Z)-octadec-9-enal + CoA + NADP+
show the reaction diagram
palmitoleoyl-CoA + NADPH + H+
(9Z)-hexadec-9-enal + CoA + NADP+
show the reaction diagram
-
-
further reduction of (9Z)-hexadec-9-enal into the corresponding (9Z)-hexadec-9-en-1-ol
-
-
palmitoyl-ACP + NADPH
1-hexadecanol + acyl-carrier protein + NADP+
show the reaction diagram
-
the recombinant acyl-CoA reductase from Simmondsia chinensis exhibits a specificty to palmitoyl-ACP and not palmitoyl-CoA when expressed in Escherichia coli
-
-
?
palmitoyl-CoA + NADP+
hexadecanal + CoA + NADPH
show the reaction diagram
palmitoyl-CoA + NADPH + H+
hexadecanal + CoA + NADP+
show the reaction diagram
palmitoyl-[acyl-carrier protein] + NADPH + H+
hexadecanal + [acyl-carrier protein] + NADP+
show the reaction diagram
-
-
further direct reduction of hexadecanal into the corresponding hexadecan-1-ol
-
?
ricinoleoyl-CoA + NADPH + H+
(9Z,12R)-12-hydroxyoctadec-9-enal + CoA + NADP+
show the reaction diagram
-
ricinoleoyl-CoA i.e. (9Z,12R)-12-hydroxyoctadec-9-enoyl-CoA
further direct reduction of (9Z,12R)-12-hydroxyoctadec-9-enal into the corresponding (9Z,12R)-octadec-9-ene-1,12-diol
-
?
stearoyl-CoA + NADP+
octadecanal + CoA + NADPH
show the reaction diagram
44% of the activity with myristoyl-CoA
-
-
?
stearoyl-CoA + NADPH + H+
octadecanal + CoA + NADP+
show the reaction diagram
tetradecanoyl-CoA + NADPH
tetradecanal + CoA + NADP+
show the reaction diagram
tetraeicos-cis-15-enoyl-CoA + NADPH
tetraeicos-cis-15-en-1-ol + CoA + NADP+
show the reaction diagram
-
-
-
-
?
additional information
?
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