1.14.19.9: tryptophan 7-halogenase
This is an abbreviated version!
For detailed information about tryptophan 7-halogenase, go to the full flat file.
Word Map on EC 1.14.19.9
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1.14.19.9
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fadh2-dependent
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dichlorination
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halometabolites
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rebeccamycin
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alpha-ketoglutarate-dependent
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haloperoxidases
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syringomycin
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alphakg-dependent
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pyrrolnitrin
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alphakg
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l-thr
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organohalogens
- 1.14.19.9
-
fadh2-dependent
-
dichlorination
-
halometabolites
- rebeccamycin
-
alpha-ketoglutarate-dependent
- haloperoxidases
-
syringomycin
-
alphakg-dependent
- pyrrolnitrin
-
alphakg
- l-thr
-
organohalogens
Reaction
Synonyms
EC 1.14.14.7, FAD-dependent halogenase, flavin-dependent halogenase, flavin-dependent tryptophan halogenase, halogenase, KtzQ, L-tryptophan-7-halogenase, PrnA, RebH, Trp 7-hal, Trp halogenase, Trp-7-Hal, Trp-7-halogenase
ECTree
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Systematic Name
Systematic Name on EC 1.14.19.9 - tryptophan 7-halogenase
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L-tryptophan:FADH2 oxidoreductase (7-halogenating)
A flavin-dependent halogenase. The enzyme from the bacterium Lechevalieria aerocolonigenes catalyses the initial step in the biosynthesis of rebeccamycin [2]. It utilizes molecular oxygen to oxidize the FADH2 cofactor, giving C4a-hydroperoxyflavin, which then reacts with chloride to produce a hypochlorite ion. The latter reacts with an active site lysine to generate a chloramine, which chlorinates the substrate. Also acts on bromide ion. cf. EC 1.14.19.58, tryptophan 5-halogenase, and EC 1.14.19.59, tryptophan 6-halogenase.