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Information on EC 1.14.19.9 - tryptophan 7-halogenase

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IUBMB Comments
In the bacterium Lechevalieria aerocolonigenes the enzyme catalyses the initial step in the biosynthesis of rebeccamycin . Also acts on bromide ion.
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Word Map
  • 1.14.19.9
  • helicase
  • unwind
  • recbcd
  • helicase-nuclease
  • holliday
  • dna-unwinding
  • winged-helix
The enzyme appears in viruses and cellular organisms
Synonyms
flavin-dependent halogenase, fad-dependent halogenase, trp halogenase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
tryptophan + FADH2 + chloride + O2 + H+ = 7-chloro-L-tryptophan + FAD + 2 H2O
show the reaction diagram
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