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1.14.19.9: tryptophan 7-halogenase

This is an abbreviated version!
For detailed information about tryptophan 7-halogenase, go to the full flat file.

Word Map on EC 1.14.19.9

Reaction

tryptophan
+
FADH2
+
chloride
+
O2
+
H+
=
7-chloro-L-tryptophan
+
FAD
+ 2 H2O

Synonyms

EC 1.14.14.7, FAD-dependent halogenase, flavin-dependent halogenase, flavin-dependent tryptophan halogenase, halogenase, KtzQ, L-tryptophan-7-halogenase, PrnA, RebH, Trp 7-hal, Trp halogenase, Trp-7-Hal, Trp-7-halogenase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.19 With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
                1.14.19.9 tryptophan 7-halogenase

Turnover Number

Turnover Number on EC 1.14.19.9 - tryptophan 7-halogenase

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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0018
(25R)-3beta-hydroxycholest-5-en-27-oate
-
pH 7.2, 30°C, in vitro two-component system of enzyme and flavin reductase to provide FADH2
0.0012
6-chloro-L-tryptophan
pH 7.0, temperature not specified in the publication, recombinant His-tagged enzyme
0.012 - 0.12
FADH2
0.0032 - 0.023
L-tryptophan
0.018 - 0.11
tryptophan