1.14.14.55: quinine 3-monooxygenase
This is an abbreviated version!
For detailed information about quinine 3-monooxygenase, go to the full flat file.
Word Map on EC 1.14.14.55
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1.14.14.55
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cyp2d6
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cyp1a2
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drug-drug
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hepatocytes
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midazolam
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ketoconazole
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p-glycoprotein
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dosing
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xenobiotics
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drug-metabolizing
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concentration-time
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clopidogrel
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testosterone
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disposition
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interindividual
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pharmacodynamics
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pharmacogenetic
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pregnane
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omeprazole
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coadministration
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rifampicin
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antiplatelet
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erythromycin
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open-label
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dextromethorphan
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phenobarbital
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tacrolimus
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ritonavir
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coadministered
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n-demethylation
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itraconazole
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grapefruit
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tolbutamide
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quinidine
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first-pass
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warfarin
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carbamazepine
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androstane
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phenytoin
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clarithromycin
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voriconazole
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pharmacogenomics
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methadone
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p450-mediated
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infinity
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ugt2b7
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efavirenz
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ugt1a1
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vkorc1
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saquinavir
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medicine
- 1.14.14.55
- cyp2d6
- cyp1a2
-
drug-drug
- hepatocytes
- midazolam
- ketoconazole
- p-glycoprotein
-
dosing
- xenobiotics
-
drug-metabolizing
-
concentration-time
- clopidogrel
- testosterone
-
disposition
-
interindividual
-
pharmacodynamics
-
pharmacogenetic
-
pregnane
- omeprazole
-
coadministration
- rifampicin
-
antiplatelet
- erythromycin
-
open-label
- dextromethorphan
- phenobarbital
- tacrolimus
- ritonavir
-
coadministered
-
n-demethylation
- itraconazole
- grapefruit
- tolbutamide
- quinidine
-
first-pass
- warfarin
- carbamazepine
-
androstane
- phenytoin
- clarithromycin
- voriconazole
-
pharmacogenomics
- methadone
-
p450-mediated
-
infinity
- ugt2b7
- efavirenz
- ugt1a1
- vkorc1
- saquinavir
- medicine
Reaction
Synonyms
CYP2C19, CYP3A, CYP3A4, CYPIIIA4, cytochrome P450 isoform, EC 1.14.13.67, NF-25, Nifedipine oxidase, P450-PCN1, quinine 3-hydroxylase, Quinine 3-monooxygenase, quinine monooxygenase
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PROTEIN VARIANTS 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
A6986AG
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single nucleotide polymorphism responsible for different CYP3A genotypes, CYP3A5 allele and genotype frequency in the populations, overview
additional information
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the CYP3A5 genotype has significant effect on quinine 3-hydroxylation in black Tanzanians, who have lower total CYP3A activity compared to a population of Swedish caucasians, overview
