1.14.14.55: quinine 3-monooxygenase
This is an abbreviated version!
For detailed information about quinine 3-monooxygenase, go to the full flat file.
Word Map on EC 1.14.14.55
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1.14.14.55
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cyp2d6
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cyp1a2
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drug-drug
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hepatocytes
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midazolam
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ketoconazole
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p-glycoprotein
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dosing
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xenobiotics
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drug-metabolizing
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concentration-time
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clopidogrel
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testosterone
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disposition
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interindividual
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pharmacodynamics
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pharmacogenetic
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pregnane
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omeprazole
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coadministration
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rifampicin
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antiplatelet
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erythromycin
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open-label
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dextromethorphan
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phenobarbital
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tacrolimus
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ritonavir
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coadministered
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n-demethylation
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itraconazole
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grapefruit
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tolbutamide
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quinidine
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first-pass
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warfarin
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carbamazepine
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androstane
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phenytoin
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clarithromycin
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voriconazole
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pharmacogenomics
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methadone
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p450-mediated
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infinity
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ugt2b7
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efavirenz
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ugt1a1
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vkorc1
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saquinavir
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medicine
- 1.14.14.55
- cyp2d6
- cyp1a2
-
drug-drug
- hepatocytes
- midazolam
- ketoconazole
- p-glycoprotein
-
dosing
- xenobiotics
-
drug-metabolizing
-
concentration-time
- clopidogrel
- testosterone
-
disposition
-
interindividual
-
pharmacodynamics
-
pharmacogenetic
-
pregnane
- omeprazole
-
coadministration
- rifampicin
-
antiplatelet
- erythromycin
-
open-label
- dextromethorphan
- phenobarbital
- tacrolimus
- ritonavir
-
coadministered
-
n-demethylation
- itraconazole
- grapefruit
- tolbutamide
- quinidine
-
first-pass
- warfarin
- carbamazepine
-
androstane
- phenytoin
- clarithromycin
- voriconazole
-
pharmacogenomics
- methadone
-
p450-mediated
-
infinity
- ugt2b7
- efavirenz
- ugt1a1
- vkorc1
- saquinavir
- medicine
Reaction
Synonyms
CYP2C19, CYP3A, CYP3A4, CYPIIIA4, cytochrome P450 isoform, EC 1.14.13.67, NF-25, Nifedipine oxidase, P450-PCN1, quinine 3-hydroxylase, Quinine 3-monooxygenase, quinine monooxygenase
ECTree
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Inhibitors
Inhibitors on EC 1.14.14.55 - quinine 3-monooxygenase
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grape seed extract
inhibition ranges from 6.4% to 26.8% dependent on the product
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green tea extract
most pronounced inhibition of CYP3A4, which ranges from 5.6% to 89.9% dependent on the product
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0.05 mM 2-naphthoflavone is inhibitory (about 60%) in the presence of low substrate concentrations (0.1 mM)
ketoconazole
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i.e. KTZ, is a antifungal drug, known as an inhibitor of, especially, the CYP3A subfamily, KTZ racemate and four separate enantiomers are evaluated for their selectivity in inhibiting quinine metabolism
ginseng products have little to no effect on the activity of CYP3A4
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additional information
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ginseng products have little to no effect on the activity of CYP3A4
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additional information
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not inhibited by lignocaine, pyrimethamine, dapsone, chloroquine, diazepam, norfloxacin, proguanil, cycloguanil, and 4-chlorophenylbiguanide
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additional information
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enzyme activity is not significantly altered following low or high dose of Nigeria honey
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