1.14.14.14: aromatase

This is an abbreviated version!
For detailed information about aromatase, go to the full flat file.

Word Map on EC 1.14.14.14

Reaction

19-hydroxyandrost-4-ene-3,17-dione
+
O2
+
[reduced NADPH-hemoprotein reductase]
=
19-oxo-androst-4-ene-3,17-dione
+ 2 H2O +
[oxidized NADPH-hemoprotein reductase]

Synonyms

Cyp19a, CYP19A1, Cyp19a1a, Cyp19a1b, Cyp19A3, cytochrome P450 aromatase, P450arom

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.14.14 aromatase

Inhibitors

Inhibitors on EC 1.14.14.14 - aromatase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,4,6-androstatriene-3,17-dione
-
treatment with the aromatase inhibitor ATD results in significantly decreased aromatase activity in male and female brain,but has no significant impact on ovarian aromatase activity
-
1-(3-bromo-4-methoxybenzene-1-sulfonyl)-3-[(1H-imidazol-1-yl)methyl]piperidine
-
-
1-[3-(2-chloro-6-nitrophenyl)benzene-1-sulfonyl]-3-[(1H-imidazol-1-yl)methyl]piperidine
-
-
19-hydroxyandrost-4-ene-3,17-dione
19-nortestosterone
-
competitive inhibitor of both aromatization and cytochrome P450 binding of androst-4-ene-3,17-dione
19-oxoandrost-4-ene-3,17-dione
2-(pyridin-3-yl)-1H-indole
-
-
2-phenyl-1H-indole-3-carbonitrile
-
-
4-[3-[(1H-imidazol-1-yl)methyl]piperidine-1-sulfonyl]-2,1,3-benzothiadiazole
-
-
5-nitro-2-phenyl-1H-indole
-
compound is inhibitory toward aromatase and induces quinone reductase 1
7,8-Benzoflavone
-
competitive inhibitor, induces spectral changes in the aromatase cytochrome P450
8-prenylnaringenin
-
flavonoid isolated from hop, inhibits enzyme activity, no effect on enzyme expression
Aminoglutethimide
-
0.005 mM, 54% residual activity
anastrozole
-
azole inhibitor, binding is independent of pH
androst-4-ene-3,17-dione
-
competitive inhibitor of both aromatization and cytochrome P450 binding of 19-nortestosterone
apigenin
-
-
chrysin
-
competitive inhibitor, induces spectral changes in the aromatase cytochrome P450
diethylaminoethyl-2,2-diphenylvalerate
-
0.05 mM, 64% residual activity
exemestane
-
steroidal inhibitor, binding is dependent of pH
flavanone
-
-
flavone
-
-
isoxanthohumol
-
flavonoid isolated from hop, inhibits enzyme activity, no effect on enzyme expression
KCN
-
5 mM, 80% residual activity
letrozole
-
-
quercetin
-
-
sildenafil
-
partial and mixed inhibitor with a maximal inhibition of 35%, KD value 0.58 mM. Sildenafil binds to the heme iron via its 6th axial water ligand
SYN 20028567
-
nonsteroidal lead compound for aromatase inhibition
xanthohumol
-
flavonoid isolated from hop, inhibits enzyme activity, no effect on enzyme expression
additional information
-