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Literature summary for 1.14.14.14 extracted from

  • Magistrato, A.; Sgrignani, J.; Krause, R.; Cavalli, A.
    Single or multiple access channels to the CYP450s active site? An answer from free energy simulations of the human aromatase enzyme (2017), J. Phys. Chem. Lett., 8, 2036-2042 .
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
free energy simulations of the entry/exit routes preferentially followed by substrate androstenedione and inhibitor letrozole. Two channels appear accessible to their entrance, while only one exit route appears to be preferential, ligand channeling is associated with large enzyme structural rearrangements Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
letrozole
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P11511
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins
-
Homo sapiens estrone + formate + 4 H2O + 3 oxidized flavoproteins
-
?

Synonyms

Synonyms Comment Organism
CYP19A1
-
Homo sapiens