Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.14.14 extracted from

  • Thompson, E.A.Jr.; Siiteri, P.K.
    The involvement of human placental microsomal cytochrome P-450 in aromatization (1974), J. Biol. Chem., 249, 5373-5378.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
19-hydroxyandrost-4-ene-3,17-dione competitive with substrates androst-4-ene-3,17-dione and 19-oxoandrost-4-ene-3,17-dione Homo sapiens
19-nortestosterone competitive inhibitor of both aromatization and cytochrome P450 binding of androst-4-ene-3,17-dione Homo sapiens
19-oxoandrost-4-ene-3,17-dione competitive with substrates androst-4-ene-3,17-dione and 19-hydroxyandrost-4-ene-3,17-dione Homo sapiens
Aminoglutethimide 0.005 mM, 54% residual activity Homo sapiens
androst-4-ene-3,17-dione competitive inhibitor of both aromatization and cytochrome P450 binding of 19-nortestosterone Homo sapiens
diethylaminoethyl-2,2-diphenylvalerate 0.05 mM, 64% residual activity Homo sapiens
KCN 5 mM, 80% residual activity Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
placenta
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the rate of entry of the first electron into the oxidized P450 substrate complex may be rate limiting in the aromatization of C19 but not C18 steroids Homo sapiens ?
-
?