1.14.13.239: carnitine monooxygenase

This is an abbreviated version!
For detailed information about carnitine monooxygenase, go to the full flat file.

Word Map on EC 1.14.13.239

Reaction

L-carnitine
+
NAD(P)H
+
H+
+
O2
=
(3R)-3-hydroxy-4-oxobutanoate
+
trimethylamine
+
NAD(P)+
+
H2O

Synonyms

carnitine TMA lyase, cntAB, yeaWX

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.13.239 carnitine monooxygenase

Systematic Name

Systematic Name on EC 1.14.13.239 - carnitine monooxygenase

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SYSTEMATIC NAME
IUBMB Comments
L-carnitine,NAD(P)H:oxygen oxidoreductase (trimethylamine-forming)
The bacterial enzyme is a complex consisting of a reductase and an oxygenase components. The reductase subunit contains a flavin and a plant-type ferredoxin [2Fe-2S] cluster, while the oxygenase subunit is a Rieske-type protein in which a [2Fe-2S] cluster is coordinated by two histidine and two cysteine residues.