Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

1.14.13.239: carnitine monooxygenase

This is an abbreviated version!
For detailed information about carnitine monooxygenase, go to the full flat file.

Word Map on EC 1.14.13.239

Reaction

L-carnitine
+
NAD(P)H
+
H+
+
O2
=
(3R)-3-hydroxy-4-oxobutanoate
+
trimethylamine
+
NAD(P)+
+
H2O

Synonyms

carnitine TMA lyase, CntA, cntAB, CntB, yeaWX

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.13.239 carnitine monooxygenase

Substrates Products

Substrates Products on EC 1.14.13.239 - carnitine monooxygenase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
1-butyl-trimethylammonium + NADH + H+ + O2
? + trimethylamine + NAD+ + H2O
show the reaction diagram
-
-
-
?
D-carnitine + NADH + H+ + O2
(3S)-3-hydroxy-4-oxobutanoate + trimethylamine + NAD+ + H2O
show the reaction diagram
D-carnitine + NADPH + H+ + O2
(3S)-3-hydroxy-4-oxobutanoate + trimethylamine + NADP+ + H2O
show the reaction diagram
gamma-butyrobetaine + NADH + H+ + O2
? + trimethylamine + NAD+ + H2O
show the reaction diagram
-
-
-
?
L-carnitine + NADH + H+ + O2
(3R)-3-hydroxy-4-oxobutanoate + trimethylamine + NAD+ + H2O
show the reaction diagram
L-carnitine + NADPH + H+ + O2
(3R)-3-hydroxy-4-oxobutanoate + trimethylamine + NADP+ + H2O
show the reaction diagram
meldonium + NADH + H+ + O2
? + trimethylamine + NAD+ + H2O
show the reaction diagram
-
-
-
?
additional information
?
-
substrates with longer alkyl chains, e.g. hexyl, or other functional groups show no activity
-
-
-