1.14.13.239: carnitine monooxygenase

This is an abbreviated version!
For detailed information about carnitine monooxygenase, go to the full flat file.

Word Map on EC 1.14.13.239

1.14.13.239

surfactant

bromide

tension

micelle

alkyltrimethylammonium

interfacial

alkane

air-water

reorientation

rieske

foam

flocculation

rieske-type

co-adsorption

langmuir

n-alkyl

fluorocarbon

trimethylamine-n-oxide

Reaction

Synonyms

carnitine TMA lyase, CntA, cntAB, CntB, yeaWX

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor

1.14.13.239 carnitine monooxygenase

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Results	in table
1495	AA Sequence
3	Cloned(Commentary)
11	Cofactor
1	Crystallization (Commentary)
2	General Information
3	IC50 Value
4	Inhibitors
1	Ki Value [mM]
2	Metals/Ions
1	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
10	Organism
1	Pathway
27	PDB ID
13	Protein Variants
1	Purification (Commentary)
1	Reaction
10	Reference
27	Substrates and Products (Substrate)
2	Subunits
13	Synonyms
1	Systematic Name

Reference

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Reference on EC 1.14.13.239 - carnitine monooxygenase

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744480

Ditullio, D.; Anderson, D.; Chen, C.S.; Sih, C.J.

L-carnitine via enzyme-catalyzed oxidative kinetic resolution

Bioorg. Med. Chem.

415-420

1994

Acinetobacter calcoaceticus, Acinetobacter calcoaceticus ATCC 39648, Acinetobacter calcoaceticus ATCC 39647

8000862

744652

Koeth, R.; Levison, B.; Culley, M.; Buffa, J.; Wang, Z.; Gregory, J.; Org, E.; Wu, Y.; Li, L.; Smith, J.; Tang, W.; Didonato, J.; Lusis, A.; Hazen, S.

gamma-Butyrobetaine is a proatherogenic intermediate in gut microbial metabolism of L-carnitine to TMAO

Cell Metab.

799-812

2014

Escherichia coli, Escherichia coli DH10B

25440057

746297

Zhu, Y.; Jameson, E.; Crosatti, M.; Schaefer, H.; Rajakumar, K.; Bugg, T.D.; Chen, Y.

Carnitine metabolism to trimethylamine by an unusual Rieske-type oxygenase from human microbiota

Proc. Natl. Acad. Sci. USA

111

4268-4273

2014

Acinetobacter baumannii (D0C9N6 AND D0C9N8), Acinetobacter baumannii, Acinetobacter baumannii ATCC19606 (D0C9N6 AND D0C9N8)

24591617

765068

Massmig, M.; Reijerse, E.; Krausze, J.; Laurich, C.; Lubitz, W.; Jahn, D.; Moser, J.

Carnitine metabolism in the human gut characterization of the two-component carnitine monooxygenase CntAB from Acinetobacter baumannii

J. Biol. Chem.

295

13065-13078

2020

Acinetobacter baumannii (D0C9N6 AND D0C9N8), Acinetobacter baumannii, Acinetobacter baumannii DSM 30007 (D0C9N6 AND D0C9N8)

32694223

765072

Quareshy, M.; Shanmugam, M.; Townsend, E.; Jameson, E.; Bugg, T.; Cameron, A.; Chen, Y.

Structural basis of carnitine monooxygenase CntA substrate specificity, inhibition, and intersubunit electron transfer

J. Biol. Chem.

296

100038

2021

Acinetobacter baumannii (A0A059ZPP5)

33158989