1.14.13.211: rifampicin monooxygenase

This is an abbreviated version!
For detailed information about rifampicin monooxygenase, go to the full flat file.

Reaction

rifampicin
+
NAD(P)H
+
O2
=
2'-N-hydroxyrifampicin
+
NAD(P)+
+
H2O

Synonyms

RIF-O, rifampicin monooxygenase, RifMO, rox

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.13.211 rifampicin monooxygenase

Crystallization

Crystallization on EC 1.14.13.211 - rifampicin monooxygenase

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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
in complex with rifampicin, to 1.8 A resolution. RifMO is a class A flavoprotein monooxygenase and is similar in fold and quaternary structure to MtmOIV and OxyS, in the mithramycin and oxytetracycline biosynthetic pathways, respectively. RifMO dimerizes via the FAD-binding domain to form a bell-shaped homodimer in solution with a maximal dimension of 110 A. The rifampicin naphthoquinone blocks access to the FAD N5 atom