1.14.13.211: rifampicin monooxygenase

This is an abbreviated version!
For detailed information about rifampicin monooxygenase, go to the full flat file.

Reaction

rifampicin
+
NAD(P)H
+
O2
=
2'-N-hydroxyrifampicin
+
NAD(P)+
+
H2O

Synonyms

RIF-O, rifampicin monooxygenase, RifMO, rox

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.13.211 rifampicin monooxygenase

Reference

Reference on EC 1.14.13.211 - rifampicin monooxygenase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hoshino, Y.;, Fujii, S., Shinonaga, H.; Arai, K.; Saito, F.; Fukai, T.; Satoh, H.; Miyazaki, Y.; Ishikawa, J.
Monooxygenation of rifampicin catalyzed by the rox gene product of Nocardia farcinica: structure elucidation, gene identification and role in drug resistance
J. Antibiot.
63
23-28
2010
Nocardia farcinica, Nocardia farcinica IFM 10152
Manually annotated by BRENDA team
Andersen, S.; Quan, S.; Gowan, B.; Dabbs, E.
Monooxygenase-like sequence of a Rhodococcus equi gene conferring increased resistance to rifampin by inactivating this antibiotic
Antimicrob. Agents Chemother.
41
218-221
1997
Rhodococcus hoagii (P95598), Rhodococcus hoagii ATCC 14887 (P95598)
Manually annotated by BRENDA team
Liu, L.K.; Abdelwahab, H.; Martin Del Campo, J.S.; Mehra-Chaudhary, R.; Sobrado, P.; Tanner, J.J.
The structure of the antibiotic deactivating, N-hydroxylating rifampicin monooxygenase
J. Biol. Chem.
291
21553-21562
2016
Nocardia farcinica (Q5YTV5), Nocardia farcinica, Nocardia farcinica IFM 10152 (Q5YTV5)
Manually annotated by BRENDA team