1.14.13.211: rifampicin monooxygenase

This is an abbreviated version!
For detailed information about rifampicin monooxygenase, go to the full flat file.

Reaction

rifampicin
+
NAD(P)H
+
O2
=
2'-N-hydroxyrifampicin
+
NAD(P)+
+
H2O

Synonyms

RIF-O, rifampicin monooxygenase, RifMO, rox

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.13.211 rifampicin monooxygenase

Cofactor

Cofactor on EC 1.14.13.211 - rifampicin monooxygenase

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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
NADPH
NADPH efficiently reduces the FAD only when rifampicin is present, implying that rifampicin binds before NADPH in the catalytic scheme