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2-aminobutyrate + glyoxylate
2-oxobutanoate + glycine
-
-
-
?
5-hydroxytryptophan + pyruvate
3-(5-hydroxyindole)-2-oxopropanoate + alanine
arginine + pyruvate
5-guanidino-2-oxopentanoate + L-alanine
-
-
-
?
asparagine + pyruvate
2-oxosuccinamate + L-alanine
cysteine + pyruvate
3-mercapto-2-oxo-propanoate + L-alanine
-
-
-
?
glutamic acid + 3-hydroxypyruvate
2-oxo-1,5-pentandioate + serine
-
-
-
-
r
glutamine + phenylpyruvate
4-carbamoyl-2-oxobutanoate + L-phenylalanine
-
-
-
?
glutamine + pyruvate
4-carbamoyl-2-oxobutanoate + L-alanine
glycine + 3-hydroxypyruvate
glyoxylate + L-serine
glycine + 3-hydroxypyruvate
L-serine + glyoxylate
glycine + pyruvate
glyoxylate + L-alanine
-
-
-
?
histidine + glyoxylate
3-(1H-imidazol-4-yl)-2-oxopropanoate + glycine
-
-
-
?
histidine + pyruvate
3-(1H-imidazol-4-yl)-2-oxopropanoate + L-alanine
isoleucine + pyruvate
3-methyl-2-oxopentanoate + alanine
-
-
-
?
L-alanine + 3-hydroxypyruvate
pyruvate + L-serine
L-alanine + glyoxylate
pyruvate + glycine
L-alanine + phenylpyruvate
pyruvate + L-phenylalanine
-
-
-
?
L-asparagine + phenylpyruvate
2-oxosuccinamate + L-phenylalanine
-
-
-
?
L-leucine + phenylpyruvate
4-methyl-2-oxopentanoate + L-phenylalanine
L-leucine + pyruvate
4-methyl-2-oxopentanoate + L-alanine
-
-
-
?
L-methionine + glyoxylate
4-methylsulfanyl-2-oxobutanoate + glycine
-
-
-
?
L-methionine + phenylpyruvate
4-methylsulfanyl-2-oxobutanoate + L-phenylalanine
L-methionine + pyruvate
4-methylsulfanyl-2-oxobutanoate + L-alanine
L-phenylalanine + glyoxylate
phenylpyruvate + glycine
-
-
-
?
L-phenylalanine + pyruvate
phenylpyruvate + L-alanine
L-serine + glyoxylate
glycine + 3-hydroxypyruvate
L-serine + oxaloacetate
3-hydroxypyruvate + L-aspartate
-
-
-
?
L-serine + phenylpyruvate
3-hydroxypyruvate + L-phenylalanine
L-serine + pyruvate
3-hydroxypyruvate + L-alanine
L-tryptophan + glyoxylate
3-indole-2-oxopropanoate + glycine
-
-
-
?
L-tryptophan + pyruvate
3-indole-2-oxopropanoate + L-alanine
-
-
-
-
?
L-tyrosine + glyoxylate
3-(4-hydroxyphenyl)-2-oxopropanoate + glycine
-
-
-
?
L-tyrosine + pyruvate
3-(4-hydroxyphenyl)-2-oxopropanoate + L-alanine
lysine + pyruvate
6-amino-2-oxohexanoate + alanine
-
-
-
-
?
ornithine + phenylpyruvate
5-amino-2-oxopentanoate + L-phenylalanine
-
-
-
?
ornithine + pyruvate
5-amino-2-oxopentanoate + L-alanine
-
-
-
?
threonine + phenylpyruvate
3-hydroxy-2-oxobutanoate + L-phenylalanine
-
-
-
-
?
valine + pyruvate
3-methyl-2-oxobutanoate + alanine
-
-
-
-
?
additional information
?
-
5-hydroxytryptophan + pyruvate
3-(5-hydroxyindole)-2-oxopropanoate + alanine
-
-
-
-
?
5-hydroxytryptophan + pyruvate
3-(5-hydroxyindole)-2-oxopropanoate + alanine
-
-
-
-
?
asparagine + pyruvate
2-oxosuccinamate + L-alanine
-
-
-
?
asparagine + pyruvate
2-oxosuccinamate + L-alanine
-
-
-
?
asparagine + pyruvate
2-oxosuccinamate + L-alanine
-
-
-
?
glutamine + pyruvate
4-carbamoyl-2-oxobutanoate + L-alanine
-
-
-
?
glutamine + pyruvate
4-carbamoyl-2-oxobutanoate + L-alanine
-
-
-
?
glutamine + pyruvate
4-carbamoyl-2-oxobutanoate + L-alanine
-
-
-
?
glycine + 3-hydroxypyruvate
glyoxylate + L-serine
-
-
-
-
r
glycine + 3-hydroxypyruvate
glyoxylate + L-serine
-
-
-
-
r
glycine + 3-hydroxypyruvate
L-serine + glyoxylate
-
-
-
r
glycine + 3-hydroxypyruvate
L-serine + glyoxylate
-
-
-
r
histidine + pyruvate
3-(1H-imidazol-4-yl)-2-oxopropanoate + L-alanine
-
-
-
?
histidine + pyruvate
3-(1H-imidazol-4-yl)-2-oxopropanoate + L-alanine
-
-
-
-
?
histidine + pyruvate
3-(1H-imidazol-4-yl)-2-oxopropanoate + L-alanine
-
-
-
?
histidine + pyruvate
3-(1H-imidazol-4-yl)-2-oxopropanoate + L-alanine
-
-
-
-
?
L-alanine + 3-hydroxypyruvate
pyruvate + L-serine
-
-
-
-
r
L-alanine + 3-hydroxypyruvate
pyruvate + L-serine
-
-
-
-
r
L-alanine + 3-hydroxypyruvate
pyruvate + L-serine
-
-
-
-
r
L-alanine + 3-hydroxypyruvate
pyruvate + L-serine
-
-
-
-
r
L-alanine + glyoxylate
pyruvate + glycine
-
-
-
?
L-alanine + glyoxylate
pyruvate + glycine
-
-
-
?
L-leucine + phenylpyruvate
4-methyl-2-oxopentanoate + L-phenylalanine
-
-
-
-
?
L-leucine + phenylpyruvate
4-methyl-2-oxopentanoate + L-phenylalanine
-
-
-
?
L-leucine + phenylpyruvate
4-methyl-2-oxopentanoate + L-phenylalanine
-
-
-
-
?
L-methionine + phenylpyruvate
4-methylsulfanyl-2-oxobutanoate + L-phenylalanine
-
-
-
?
L-methionine + phenylpyruvate
4-methylsulfanyl-2-oxobutanoate + L-phenylalanine
-
-
-
?
L-methionine + pyruvate
4-methylsulfanyl-2-oxobutanoate + L-alanine
-
-
-
?
L-methionine + pyruvate
4-methylsulfanyl-2-oxobutanoate + L-alanine
-
-
-
?
L-methionine + pyruvate
4-methylsulfanyl-2-oxobutanoate + L-alanine
-
-
-
?
L-methionine + pyruvate
4-methylsulfanyl-2-oxobutanoate + L-alanine
-
-
-
?
L-phenylalanine + pyruvate
phenylpyruvate + L-alanine
-
-
-
?
L-phenylalanine + pyruvate
phenylpyruvate + L-alanine
-
-
-
-
?
L-phenylalanine + pyruvate
phenylpyruvate + L-alanine
-
-
-
?
L-phenylalanine + pyruvate
phenylpyruvate + L-alanine
-
-
-
-
?
L-phenylalanine + pyruvate
phenylpyruvate + L-alanine
-
-
-
?
L-serine + glyoxylate
glycine + 3-hydroxypyruvate
-
-
-
-
r
L-serine + glyoxylate
glycine + 3-hydroxypyruvate
-
-
-
r
L-serine + glyoxylate
glycine + 3-hydroxypyruvate
-
-
-
-
r
L-serine + glyoxylate
glycine + 3-hydroxypyruvate
-
-
-
r
L-serine + glyoxylate
glycine + 3-hydroxypyruvate
-
-
-
-
r
L-serine + glyoxylate
glycine + 3-hydroxypyruvate
-
-
-
-
r
L-serine + glyoxylate
glycine + 3-hydroxypyruvate
-
-
-
-
r
L-serine + glyoxylate
glycine + 3-hydroxypyruvate
-
-
-
-
r
L-serine + glyoxylate
glycine + 3-hydroxypyruvate
-
-
-
r
L-serine + glyoxylate
glycine + 3-hydroxypyruvate
-
-
-
r
L-serine + phenylpyruvate
3-hydroxypyruvate + L-phenylalanine
-
little activity detected
-
-
r
L-serine + phenylpyruvate
3-hydroxypyruvate + L-phenylalanine
-
little activity detected
-
-
r
L-serine + phenylpyruvate
3-hydroxypyruvate + L-phenylalanine
-
-
-
r
L-serine + phenylpyruvate
3-hydroxypyruvate + L-phenylalanine
-
-
-
r
L-serine + pyruvate
3-hydroxypyruvate + L-alanine
-
-
-
r
L-serine + pyruvate
3-hydroxypyruvate + L-alanine
-
-
-
-
r
L-serine + pyruvate
3-hydroxypyruvate + L-alanine
-
L-serine metabolism
-
-
r
L-serine + pyruvate
3-hydroxypyruvate + L-alanine
-
gluconeogenesis from serine
-
-
r
L-serine + pyruvate
3-hydroxypyruvate + L-alanine
-
-
-
r
L-serine + pyruvate
3-hydroxypyruvate + L-alanine
glyoxylate detoxification, physiological role in tryptophan catabolism
-
-
r
L-serine + pyruvate
3-hydroxypyruvate + L-alanine
-
-
-
-
r
L-serine + pyruvate
3-hydroxypyruvate + L-alanine
-
gluconeogenesis from serine
-
-
r
L-serine + pyruvate
3-hydroxypyruvate + L-alanine
-
-
-
-
r
L-serine + pyruvate
3-hydroxypyruvate + L-alanine
-
-
-
?
L-serine + pyruvate
3-hydroxypyruvate + L-alanine
-
L-serine metabolism
-
-
r
L-serine + pyruvate
3-hydroxypyruvate + L-alanine
-
glyoxylate metabolism
-
-
r
L-serine + pyruvate
3-hydroxypyruvate + L-alanine
-
-
-
-
r
L-serine + pyruvate
3-hydroxypyruvate + L-alanine
-
gluconeogenesis from serine
-
-
r
L-serine + pyruvate
3-hydroxypyruvate + L-alanine
-
-
-
-
r
L-serine + pyruvate
3-hydroxypyruvate + L-alanine
-
-
-
-
r
L-serine + pyruvate
3-hydroxypyruvate + L-alanine
-
L-serine metabolism
-
-
r
L-serine + pyruvate
3-hydroxypyruvate + L-alanine
-
gluconeogenesis from serine
-
-
r
L-serine + pyruvate
3-hydroxypyruvate + L-alanine
-
-
-
-
r
L-serine + pyruvate
3-hydroxypyruvate + L-alanine
-
-
-
-
r
L-serine + pyruvate
3-hydroxypyruvate + L-alanine
-
L-serine metabolism
-
-
r
L-serine + pyruvate
3-hydroxypyruvate + L-alanine
-
-
-
-
r
L-serine + pyruvate
3-hydroxypyruvate + L-alanine
-
gluconeogenesis from serine
-
-
r
L-serine + pyruvate
3-hydroxypyruvate + L-alanine
-
glyoxylate metabolism
-
-
r
L-serine + pyruvate
3-hydroxypyruvate + L-alanine
-
-
-
-
r
L-serine + pyruvate
3-hydroxypyruvate + L-alanine
-
-
-
-
r
L-serine + pyruvate
3-hydroxypyruvate + L-alanine
-
gluconeogenesis from serine
-
-
r
L-serine + pyruvate
3-hydroxypyruvate + L-alanine
-
glyoxylate metabolism
-
-
r
L-serine + pyruvate
3-hydroxypyruvate + L-alanine
-
-
-
?
L-serine + pyruvate
3-hydroxypyruvate + L-alanine
-
-
-
?
L-tyrosine + pyruvate
3-(4-hydroxyphenyl)-2-oxopropanoate + L-alanine
-
-
-
?
L-tyrosine + pyruvate
3-(4-hydroxyphenyl)-2-oxopropanoate + L-alanine
-
-
-
-
?
L-tyrosine + pyruvate
3-(4-hydroxyphenyl)-2-oxopropanoate + L-alanine
-
-
-
-
?
L-tyrosine + pyruvate
3-(4-hydroxyphenyl)-2-oxopropanoate + L-alanine
-
-
-
-
?
additional information
?
-
-
D-alanine is no substrate
-
-
?
additional information
?
-
-
highly specific for serine as the amino donor
-
-
?
additional information
?
-
-
2-oxoglutarate, indol-3-ylpyruvate and p-hydroxyphenylpyruvate are no substrates
-
-
?
additional information
?
-
amino-adipate, asparagine, aspartate, glutamate, isoleucine, lysine, threonine and valine are no substrates
-
-
?
additional information
?
-
-
amino-adipate, asparagine, aspartate, glutamate, isoleucine, lysine, threonine and valine are no substrates
-
-
?
additional information
?
-
-
highly specific for serine as the amino donor
-
-
?
additional information
?
-
-
2-oxoglutarate, indol-3-ylpyruvate and p-hydroxyphenylpyruvate are no substrates
-
-
?
additional information
?
-
-
class IV aminotransferase, identical with EC 2.6.1.44
-
-
?
additional information
?
-
the enzyme is also active as alanine-glyoxylate aminotransferase, EC 2.6.1.44
-
-
-
additional information
?
-
-
the enzyme is also active as alanine-glyoxylate aminotransferase, EC 2.6.1.44
-
-
-
additional information
?
-
-
2-oxoglutarate, indol-3-ylpyruvate and p-hydroxyphenylpyruvate are no substrates
-
-
?
additional information
?
-
-
highly specific for serine as the amino donor
-
-
?
additional information
?
-
-
identical with histidine-pyruvate aminotransferase isoenzyme 1, isoleucine and oxoglutarate are no substrates
-
-
?
additional information
?
-
-
class IV aminotransferase, identical with EC 2.6.1.44
-
-
?
additional information
?
-
-
class IV aminotransferase, identical with EC 2.6.1.44
-
-
?
additional information
?
-
-
2-oxoglutarate, indol-3-ylpyruvate and p-hydroxyphenylpyruvate are no substrates
-
-
?
additional information
?
-
-
enzyme converts L-hydroxyproline-derived glyoxylate into glycine in situ, preventing undesirable overflow into the production of oxalate
-
-
?
additional information
?
-
-
identical with histidine-pyruvate aminotransferase isoenzyme 1, isoleucine and oxoglutarate are no substrates
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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Smith, I.K.
Purification and characterization of serine:glyoxylate aminotransferase from kidney bean (Phaseolus vulgaris)
Biochim. Biophys. Acta
321
156-164
1973
Phaseolus vulgaris
brenda
Ishikawa, K.; Kaneko, E.; Ichiyama, A.
Pyridoxal 5'-phosphate binding of a recombinant rat serine: pyruvate/alanine:glyoxylate aminotransferase
J. Biochem.
119
970-978
1996
Rattus norvegicus
brenda
Oda, T.; Uchida, C.; Miura, S.
Mitochondrial targeting signal-induced conformational change and repression of the peroxisomal targeting signal of the precursor for rat liver serine:pyruvate/alanine:glyoxylate aminotransferase
J. Biochem.
127
665-671
2000
Rattus norvegicus, Rattus norvegicus Wistar
brenda
Han, Q.; Li, J.
Comparative characterization of Aedes 3-hydroxykynurenine transaminase/alanine glyoxylate transaminase and Drosophila serine pyruvate aminotransferase
FEBS Lett.
527
199-204
2002
Drosophila melanogaster (Q9W3Z3), Drosophila melanogaster
brenda
Sallach, H.J.
Formation of serine from hydroxypyruvate and L-alanine
J. Biol. Chem.
223
1101-1108
1956
Canis lupus familiaris, Neurospora crassa
brenda
Cheung, G.P.; Rosenblum, I.Y.; Sallach, H.J.
Comparative studies of enzymes related to serine metabolism in hogher plants
Plant Physiol.
13
1813-1820
1968
Pisum sativum
-
brenda
Noguchi, T.; Okuno, E.; Kido, R.
Identity of isoenzyme 1 of histidine-pyruvate aminotransferase with serine-pyruvate aminotransferase
Biochem. J.
159
607-613
1976
Rattus norvegicus, Rattus norvegicus Donryu
brenda
Noguchi, T.; Takada, Y.; Kido, R.
Characteristics of hepatic serine-pyruvate aminotransferase in different mammalian species
Biochem. J.
161
609-614
1977
Canis lupus familiaris, Felis catus, Mus musculus, Rattus norvegicus
brenda
Youngson, A.; Cowey, C.B.; Walton, M.J.
Some properties of serine pyruvate aminotransferase purified from liver of rainbow trout Salmo gairdneri
Comp. Biochem. Physiol. B
73
393-398
1982
Oncorhynchus mykiss
-
brenda
Yokota, S.; Oda, T.
Fine localization of serine:pyruvate aminotransferase in rat hepatocytes revealed by a post-embedding immunocytochemical technique
Histochemistry
80
591-595
1984
Rattus norvegicus
brenda
Oda, T.; Miyajima, H.; Suzuki, Y.; Ito, T.; Yokota, S.; Hoshino, M.; Ichiyama, A.
Purification and characterization of the active serine: pyruvate aminotransferase of rat liver mitochondria expressed in Escherichia coli
J. Biochem.
106
460-467
1989
Rattus norvegicus
brenda
Oda, T.; Funai, T.; Miura, S.
In vitro association with peroxisomes and conformational change of peroxisomal serine:pyruvate/alanine:glyoxylate aminotransferase in rat and human livers
Biochem. Biophys. Res. Commun.
228
341-346
1996
Homo sapiens, Rattus norvegicus
brenda
Xue, H.H.; Sakaguchi, T.; Fujie, M.; Ogawa, H.; Ichiyama, A.
Flux of the L-serine metabolism in rabbit, human, and dog livers. Substantial contributions of both mitochondrial and peroxisomal serine:pyruvate/alanine:glyoxylate aminotransferase
J. Biol. Chem.
274
16028-16033
1999
Canis lupus familiaris, Oryctolagus cuniculus, Homo sapiens, Rattus norvegicus, Rattus norvegicus Wistar
brenda
Ichiyama, A.; Xue, H.H.; Oda, T.; Uchida, C.; Sugiyama, T.; Maeda-Nakai, E.; Sato, K.; Nagai, E.; Watanabe, S.; Takayama, T.
Oxalate synthesis in mammals: properties and subcellular distribution of serine:pyruvate/alanine:glyoxylate aminotransferase in the liver
Mol. Urol.
4
333-340
2000
Canis lupus familiaris, Homo sapiens, Oryctolagus cuniculus
brenda
Oda, T.; Mizuno, T.; Ito, K.; Funai, T.; Ichiyama, A.; Miura, S.
Peroxisomal and mitochondrial targeting of serine:pyruvate/alanine:glyoxylate aminotransferase in rat liver
Cell Biochem. Biophys.
32
277-281
2000
Rattus norvegicus
-
brenda
Sugiyama, T.; Uchida, C.; Oda, T.; Kitagawa, M.; Hayashi, H.; Ichiyama, A.
Involvement of CCAAT/enhancer-binding protein in regulation of the rat serine:pyruvate/alanine:glyoxylate aminotransferase gene expression
FEBS Lett.
508
16-22
2001
Rattus norvegicus
brenda
Mizuno, T.; Ito, K.; Uchida, C.; Kitagawa, M.; Ichiyama, A.; Miura, S.; Fujita, K.; Oda, T.
Analyses in transfected cells and in vitro of a putative peroxisomal targeting signal of rat liver serine:pyruvate aminotransferase
Histochem. Cell Biol.
118
321-328
2002
Rattus norvegicus
brenda
Uchida, C.; Oda, T.; Sugiyama, T.; Otani, S.; Kitagawa, M.; Ichiyama, A.
The role of Sp1 and AP-2 in basal and protein kinase A-induced expression of mitochondrial serine:pyruvate aminotransferase in hepatocytes
J. Biol. Chem.
277
39082-39092
2002
Rattus norvegicus
brenda
Hagopian, K.; Ramsey, J.J.; Weindruch, R.
Serine utilization in mouse liver: influence of caloric restriction and aging
FEBS Lett.
579
2009-2013
2005
Mus musculus
brenda
Takayama, T.; Fujita, K.; Suzuki, K.; Sakaguchi, M.; Fujie, M.; Nagai, E.; Watanabe, S.; Ichiyama, A.; Ogawa, Y.
Control of oxalate formation from L-hydroxyproline in liver mitochondria
J. Am. Soc. Nephrol.
14
939-946
2003
Rattus norvegicus
brenda
Sayer, C.; Bommer, M.; Isupov, M.; Ward, J.; Littlechild, J.
Crystal structure and substrate specificity of the thermophilic serine:pyruvate aminotransferase from Sulfolobus solfataricus
Acta Crystallogr. Sect. D
68
763-772
2012
Saccharolobus solfataricus (Q97VM5), Saccharolobus solfataricus, Saccharolobus solfataricus P2 (Q97VM5)
brenda
Sun, Y.; Li, W.; Shen, S.; Yang, X.; Lu, B.; Zhang, X.; Lu, P.; Shen, Y.; Ji, J.
Loss of alanine-glyoxylate and serine-pyruvate aminotransferase expression accelerated the progression of hepatocellular carcinoma and predicted poor prognosis
J. Transl. Med.
17
390
2019
Homo sapiens (P21549), Homo sapiens
brenda