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Literature summary for 2.6.1.51 extracted from
- Crystal structure and substrate specificity of the thermophilic serine:pyruvate aminotransferase from Sulfolobus solfataricus (2012), Acta Crystallogr. Sect. D, 68, 763-772.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Saccharolobus solfataricus |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| 1.8 A resolution. The structure of the Sulfolobus solfataricus enzyme is determined with an amino form of the cofactor pyridoxamine 5'-phosphate bound in the active site and in complex with gabaculine, an aminotransferase inhibitor. These structures show the changes in the enzyme active site during the course of the catalytic reaction | Saccharolobus solfataricus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharolobus solfataricus | Q97VM5 | - |
- |
| Saccharolobus solfataricus P2 | Q97VM5 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Saccharolobus solfataricus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-serine + pyruvate | - |
Saccharolobus solfataricus | 3-hydroxypyruvate + L-alanine | - |
? |  |
| L-serine + pyruvate | - |
Saccharolobus solfataricus P2 | 3-hydroxypyruvate + L-alanine | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| homodimer | - |
Saccharolobus solfataricus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| serine:pyruvate aminotransferase | - |
Saccharolobus solfataricus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.3 | - |
assay at | Saccharolobus solfataricus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | the structure of the protein is a homodimer that adopts the type I fold of pyridoxal 5'-phosphate-dependent aminotransferases. The structure reveals the PLP cofactor covalently bound in the active site to the active-site lysine in the internal aldimine form | Saccharolobus solfataricus | |
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