Literature summary for 2.6.1.51 extracted from

Han, Q.; Li, J.
Comparative characterization of Aedes 3-hydroxykynurenine transaminase/alanine glyoxylate transaminase and Drosophila serine pyruvate aminotransferase (2002), FEBS Lett., 527, 199-204.

Search for more literature for 2.6.1.51

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in SF9 cells, using a insect/baculovirus expression system	Drosophila melanogaster

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
51	-	pyruvate	pH 7.0, 50°C, recombinant enzyme	Drosophila melanogaster
64	-	glyoxylate	pH 7.0, 50°C, recombinant enzyme	Drosophila melanogaster
149	-	alanine	pH 7.0, 50°C, recombinant enzyme	Drosophila melanogaster
256	-	serine	pH 7.0, 50°C, recombinant enzyme	Drosophila melanogaster

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-serine + pyruvate	Drosophila melanogaster	glyoxylate detoxification, physiological role in tryptophan catabolism	3-hydroxypyruvate + L-alanine	-	r

Organism

Organism	UniProt	Comment	Textmining
Drosophila melanogaster	Q9W3Z3	-	-

Purification (Commentary)

Purification (Comment)	Organism
recombinant enzyme	Drosophila melanogaster

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2-aminobutyrate + glyoxylate	-	Drosophila melanogaster	2-oxobutanoate + glycine	-	?
arginine + pyruvate	-	Drosophila melanogaster	5-guanidino-2-oxopentanoate + L-alanine	-	?
cysteine + pyruvate	-	Drosophila melanogaster	3-mercapto-2-oxo-propanoate + L-alanine	-	?
glycine + pyruvate	-	Drosophila melanogaster	glyoxylate + L-alanine	-	?
histidine + glyoxylate	-	Drosophila melanogaster	3-(1H-imidazol-4-yl)-2-oxopropanoate + glycine	-	?
histidine + pyruvate	-	Drosophila melanogaster	3-(1H-imidazol-4-yl)-2-oxopropanoate + L-alanine	-	?
L-alanine + glyoxylate	-	Drosophila melanogaster	pyruvate + glycine	-	?
L-leucine + pyruvate	-	Drosophila melanogaster	4-methyl-2-oxopentanoate + L-alanine	-	?
L-methionine + glyoxylate	-	Drosophila melanogaster	4-methylsulfanyl-2-oxobutanoate + glycine	-	?
L-methionine + pyruvate	-	Drosophila melanogaster	4-methylsulfanyl-2-oxobutanoate + L-alanine	-	?
L-phenylalanine + glyoxylate	-	Drosophila melanogaster	phenylpyruvate + glycine	-	?
L-phenylalanine + pyruvate	-	Drosophila melanogaster	phenylpyruvate + L-alanine	-	?
L-serine + glyoxylate	-	Drosophila melanogaster	glycine + 3-hydroxypyruvate	-	r
L-serine + pyruvate	-	Drosophila melanogaster	3-hydroxypyruvate + L-alanine	-	r
L-serine + pyruvate	glyoxylate detoxification, physiological role in tryptophan catabolism	Drosophila melanogaster	3-hydroxypyruvate + L-alanine	-	r
L-tryptophan + glyoxylate	-	Drosophila melanogaster	3-indole-2-oxopropanoate + glycine	-	?
L-tyrosine + glyoxylate	-	Drosophila melanogaster	3-(4-hydroxyphenyl)-2-oxopropanoate + glycine	-	?
L-tyrosine + pyruvate	-	Drosophila melanogaster	3-(4-hydroxyphenyl)-2-oxopropanoate + L-alanine	-	?
additional information	amino-adipate, asparagine, aspartate, glutamate, isoleucine, lysine, threonine and valine are no substrates	Drosophila melanogaster	?	-	?

Synonyms

Synonyms	Comment	Organism
Dm-Spat	-	Drosophila melanogaster

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
113	-	glyoxylate	-	Drosophila melanogaster
131	-	alanine	-	Drosophila melanogaster

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Release 2023.1 (January 2023)