2.7.7.47: streptomycin 3''-adenylyltransferase

This is an abbreviated version!
For detailed information about streptomycin 3''-adenylyltransferase, go to the full flat file.

Reaction

Synonyms

AAD (3''), aadA, AadA6, aminoglycoside (3'')(9) adenylyltransferase, aminoglycoside 3''-adenylyltransferase, aminoglycoside 3'-adenyltransferase, aminoglycoside adenyltransferase, aminoglycoside adenyltransferase A, aminoglycoside adenyltransferase type A, aminoglycoside adenylyltransferase, ANT(3'')-II, ANT(3'')-Ii/AAC(6')-IId, SMATase, str, streptomycin adenylate synthetase, streptomycin adenyltransferase, streptomycin adenylylase, streptomycin adenylyltransferase, streptomycin-spectinomycin adenylyltransferase

ECTree

     2 Transferases

         2.7 Transferring phosphorus-containing groups

             2.7.7 Nucleotidyltransferases

                2.7.7.47 streptomycin 3''-adenylyltransferase

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Results	in table
2	Activating Compound
2172	AA Sequence
8	Application
1	CAS Registry Number
17	Cloned(Commentary)
3	Cofactor
4	Crystallization (Commentary)
25	General Information
1	General Stability
13	Inhibitors
6	kcat/KM [mM/s]
6	Ki Value [mM]
11	KM Value [mM]
4	Localization
7	Metals/Ions
4	Molecular Weight [Da]
46	Natural Substrates/ Products (Substrates)
57	Organism
12	PDB ID
5	pH Optimum
4	pI Value
17	Protein Variants
11	Purification (Commentary)
1	Reaction
1	Reaction Type
53	Reference
3	Specific Activity [micromol/min/mg]
79	Substrates and Products (Substrate)
7	Subunits
61	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
3	Temperature Stability [°C]
9	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 2.7.7.47 - streptomycin 3''-adenylyltransferase

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

(1R,4R)-4-[3-[(5)-([4-[amino(iminimyl)methyl]phenyl]amino)(carboxylato)methyl]-5-ethoxylphenoxy]-1-methypiperidin-1-ium

Serratia marcescens

-

-

761840

-

(1S,3S,4R)-4-[2-(2-chlorophenoxy)-5,7-dihydroxy-4-oxo-4H-chromen-8-yl]-3-hydroxy-1-methylpiperidin-1-ium

Serratia marcescens

-

-

761840

-

2-(1-(2-(4-methylpiperazin-1-yl)acetyl)-3-oxopiperazin-2-yl)-N-phenylacetamide

Serratia marcescens

-

-

761840

-

2-[[4-[[(4R)-3[(3R)-3-azaniumyl]-4-(2-fluorophenyl)butanoyl]-(1,3-thiazolidin-4-yl]formamido]methyl)phenyl]acetate

Serratia marcescens

-

-

761840

-

9-O-(adenosine-5'-phophoryl)spectinomycin

Serratia marcescens

-

product inhibition of ANT(3'')-Ii domain

672194

AMP-CPP

Serratia marcescens

-

dead-end inhibition of ANT(3'')-Ii domain

672194

clindamycin

Klebsiella pneumoniae

P08881

residues Phe34, Asp60, Arg63, Gln64, Leu68, Glu87, Thr89, Val90 are responsible for positioning clindamycin into the active site

723011

kanamycin A

2 entries

N-(4-fluorophenyl)-2-(1-(2-(4-methylpiperazin-1-yl)acetyl)-3-oxopiperazin-2-yl)acetamide

Serratia marcescens

-

-

761840

-

neomycin

Escherichia coli

-

non-competitive versus streptomycin and uncompetitive versus ATP

661382

streptomycin

Pseudomonas aeruginosa

Q9RGC2

strong substrate inhibition at 1mM MgCl2

739973

tobramycin

Escherichia coli

-

non-competitive versus streptomycin and uncompetitive versus ATP

661382

kanamycin A

Pseudomonas aeruginosa

Q9RGC2

competitive

739973

kanamycin A

Serratia marcescens

-

dead-end inhibition of ANT(3'')-Ii domain

672194