Literature summary for 2.7.7.47 extracted from

Jana, S.; Deb, J.K.
Kinetic mechanism of streptomycin adenylyltransferase from a recombinant Escherichia coli (2005), Biotechnol. Lett., 27, 519-524.

Search for more literature for 2.7.7.47

Inhibitors

Inhibitors	Comment	Organism	Structure
neomycin	non-competitive versus streptomycin and uncompetitive versus ATP	Escherichia coli
tobramycin	non-competitive versus streptomycin and uncompetitive versus ATP	Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + streptomycin	Escherichia coli	important mechanism of streptomycin modification is through ATP-dependent O -adenylation	diphosphate + 3''-adenylylstreptomycin	-	?

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + streptomycin	important mechanism of streptomycin modification is through ATP-dependent O -adenylation	Escherichia coli	diphosphate + 3''-adenylylstreptomycin	-	?
ATP + streptomycin	sequential mechanism, ordered substrate binding where ATP binds first and then streptomycin and diphosphate is released prior to formation of AMP-streptomycin	Escherichia coli	diphosphate + 3''-adenylylstreptomycin	-	?

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Release 2023.1 (January 2023)