2.7.4.24: diphosphoinositol-pentakisphosphate 1-kinase

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For detailed information about diphosphoinositol-pentakisphosphate 1-kinase, go to the full flat file.

Word Map on EC 2.7.4.24

2.7.4.24

pyrophosphate

polyphosphate

pp-insps

hexakisphosphate

5-insp7

tetrakisphosphate

bisdiphosphoinositol

spx

medicine

Reaction

1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate

1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate

Synonyms

ATP:5-diphospho-1D-myo-inositol-pentakisphosphate phosphotransferase, diphospho-myo-inositol pentakisphosphate 5-kinase, diphosphoinositol pentakisphosphate kinase, diphosphoinositol pentakisphosphate kinase 2, diphosphoinositol-pentakisphosphate 1/3-kinase, diphosphoinositol-pentakisphosphate kinase, EC 2.7.1.155, IP7 kinase, kinase (phosphorylating), diphosphoinositol 1,2,3,4,5-pentakisphosphate 5-, More, PP-InsP5 kinase, PP-IP5 kinase, PPIP5K, PPIP5K1, PPIP5K2, VIP, VIP1, VIP2

ECTree

2 Transferases

2.7 Transferring phosphorus-containing groups

2.7.4 Phosphotransferases with a phosphate group as acceptor

2.7.4.24 diphosphoinositol-pentakisphosphate 1-kinase

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Results	in table
16	Activating Compound
9099	AA Sequence
2	Application
1	CAS Registry Number
9	Cloned(Commentary)
7	Cofactor
3	Crystallization (Commentary)
4	Disease/ Diagnostics
8	General Information
9	IC50 Value
20	Inhibitors
6	kcat/KM [mM/s]
12	KM Value [mM]
1	Localization
4	Metals/Ions
7	Molecular Weight [Da]
18	Natural Substrates/ Products (Substrates)
20	Organism
1	Pathway
20	PDB ID
7	pH Optimum
1	pH Range
16	Protein Variants
7	Purification (Commentary)
2	Reaction
1	Reaction Type
20	Reference
12	Source Tissue
1	Specific Activity [micromol/min/mg]
3	Storage Stability
35	Substrates and Products (Substrate)
4	Subunits
54	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
1	Temperature Range [°C]
1	Temperature Stability [°C]
5	Turnover Number [1/s]

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Cloned on EC 2.7.4.24 - diphosphoinositol-pentakisphosphate 1-kinase

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DNA and amino acid sequence determination and analysis

Rattus norvegicus

P0C644

698738

expressed in Escherichia coli BL21(DE3) cells

Homo sapiens

O43314

721882

expression in Drosophila melanogaster

Homo sapiens

Q6PFW1

760744

expression of wild-type Saccharomyces cerevisiae Vip1 kinase domain and of mutant Vip1 fused to human GSTIP6K1 as GST-tagged proteins in bacteria

2 entries

functional overexpression of isozymes PPIP5K1 and PPIP5K2 in HEK-293 cells, expression of isozyme PPIP5K1 in Escherichia coli

Homo sapiens

Q6PFW1

698738

gene VIP1, DNA and amino acid sequence determination and analysis, VIP1 expression in mutant yeast, functional expression of CFP- or GST-tagged VIP1 in HEK-293T cells

Homo sapiens

O43314, Q6PFW1

698737

gene VIP2, DNA and amino acid sequence determination and analysis, functional expression of CFP- or GST-tagged VIP2 in HEK-293T cells

Homo sapiens

O43314, Q6PFW1

698737

recombinant expression of wild-type and mutant enzymes

Homo sapiens

O43314

738042