2.7.4.24: diphosphoinositol-pentakisphosphate 1-kinase

This is an abbreviated version!
For detailed information about diphosphoinositol-pentakisphosphate 1-kinase, go to the full flat file.

Reaction

Synonyms

ATP:5-diphospho-1D-myo-inositol-pentakisphosphate phosphotransferase, diphospho-myo-inositol pentakisphosphate 5-kinase, diphosphoinositol pentakisphosphate kinase, diphosphoinositol pentakisphosphate kinase 2, diphosphoinositol-pentakisphosphate 1/3-kinase, diphosphoinositol-pentakisphosphate kinase, EC 2.7.1.155, IP7 kinase, kinase (phosphorylating), diphosphoinositol 1,2,3,4,5-pentakisphosphate 5-, More, PP-InsP5 kinase, PP-IP5 kinase, PPIP5K, PPIP5K1, PPIP5K2, VIP, VIP1, VIP2

ECTree

     2 Transferases

         2.7 Transferring phosphorus-containing groups

             2.7.4 Phosphotransferases with a phosphate group as acceptor

                2.7.4.24 diphosphoinositol-pentakisphosphate 1-kinase

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Results	in table
16	Activating Compound
9099	AA Sequence
2	Application
1	CAS Registry Number
9	Cloned(Commentary)
7	Cofactor
3	Crystallization (Commentary)
4	Disease/ Diagnostics
8	General Information
9	IC50 Value
20	Inhibitors
6	kcat/KM [mM/s]
12	KM Value [mM]
1	Localization
4	Metals/Ions
7	Molecular Weight [Da]
18	Natural Substrates/ Products (Substrates)
20	Organism
1	Pathway
20	PDB ID
7	pH Optimum
1	pH Range
16	Protein Variants
7	Purification (Commentary)
2	Reaction
1	Reaction Type
20	Reference
12	Source Tissue
1	Specific Activity [micromol/min/mg]
3	Storage Stability
35	Substrates and Products (Substrate)
4	Subunits
54	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
1	Temperature Range [°C]
1	Temperature Stability [°C]
5	Turnover Number [1/s]

KM Value

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KM Value on EC 2.7.4.24 - diphosphoinositol-pentakisphosphate 1-kinase

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KM VALUE [mM]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.000022

1,5-bis-diphospho-1D-myo-inositol 2,3,4,6-tetrakisphosphate

Homo sapiens

O43314

isoform PPIP5K2, in 20 mM HEPES-NaOH pH 7.2, 50 mM KCl, at 37°C

721882

0.00011

1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate

Homo sapiens

O43314

isoform PPIP5K2, in 20 mM HEPES-NaOH pH 7.2, 50 m MKCl, at 37°C

721882

1.94

1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate

Rattus norvegicus

-

pH 6.8, 37°C

645048

0.0001 - 0.00019

1D-myo-inositol 5-diphosphate pentakisphosphate

2 entries

0.00006

5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate

Homo sapiens

O43314

isoform PPIP5K2, in 20 mM HEPES-NaOH pH 7.2, 50 mM KCl, at 37°C

721882

0.0052 - 1.39

ADP

3 entries

0.022 - 1.89

ATP

2 entries

0.7

diphosphoinositol pentakisphosphate

Rattus norvegicus

-

pH 6.8, 37°C

645048

0.0001

1D-myo-inositol 5-diphosphate pentakisphosphate

Homo sapiens

O43314, Q6PFW1

pH 6.2, 37°C, VIP1

698737

0.00019

1D-myo-inositol 5-diphosphate pentakisphosphate

Homo sapiens

O43314, Q6PFW1

pH 6.2, 37°C, VIP2

698737

0.0052

ADP

Homo sapiens

O43314

isoform PPIP5K2, using 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate as cosubstrate, in 20 mM HEPES-NaOH pH 7.2, 50 mM KCl, at 37°C

721882

0.9

ADP

Homo sapiens

O43314

isoform PPIP5K2, using 1,5-bis-diphospho-1D-myo-inositol 2,3,4,6-tetrakisphosphate as cosubstrate, in 20 mM HEPES-NaOH pH 7.2, 50 mM KCl, at 37°C

721882

1.39

ADP

Rattus norvegicus

-

pH 6.8, 37°C

645048

0.022

ATP

Homo sapiens

O43314

isoform PPIP5K2, using 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate as cosubstrate, in 20 mM HEPES-NaOH pH 7.2, 50 mM KCl, at 37°C

721882

1.89

ATP

Rattus norvegicus

-

pH 6.8, 37°C

645048