2.6.1.86: 2-amino-4-deoxychorismate synthase

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For detailed information about 2-amino-4-deoxychorismate synthase, go to the full flat file.

Reaction

Synonyms

2-amino-2-deoxyisochorismate (ADIC) synthase, 2-amino-2-deoxyisochorismate synthase, 2-amino-2desoxyisochorismate synthase, ADCS, ADIC synthase, aminodeoxyisochorismate synthase, PabA, PhzE, SgcD

ECTree

     2 Transferases

         2.6 Transferring nitrogenous groups

             2.6.1 Transaminases

                2.6.1.86 2-amino-4-deoxychorismate synthase

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Results	in table
128	AA Sequence
1	Application
1	CAS Registry Number
3	Cloned(Commentary)
1	Crystallization (Commentary)
3	Inhibitors
2	KM Value [mM]
3	Metals/Ions
3	Molecular Weight [Da]
2	Natural Substrates/ Products (Substrates)
7	Organism
6	Pathway
1	pH Optimum
1	pH Range
3	Protein Variants
3	Purification (Commentary)
1	Reaction
1	Reaction Type
7	Reference
8	Substrates and Products (Substrate)
4	Subunits
13	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Range [°C]
3	Turnover Number [1/s]

Application

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Application on EC 2.6.1.86 - 2-amino-4-deoxychorismate synthase

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APPLICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

biotechnology

Escherichia coli

P00903

conversion of aminodeoxychorismate synthase into anthranilate synthase employing a bioinformatics method for predicting mutations required to functionally interconvert homologous enzymes. Complementation of an anthranilate synthase-deficient strain of Escherichia coli grown on minimal medium leads to several aminodeoxychorismate synthase mutants that allow growth in 6 days compared to 2 days for wild-type anthranilate synthase. The purified mutant enzymes catalyze the conversion of chorismate to anthranilate at rates that are about 50% of the rate of wild-type aminodeoxychorismate synthase-catalyzed conversion of chorismate to aminodeoxychorismate. The residues mutated do not contact the substrate

737705