2.5.1.56: N-acetylneuraminate synthase

This is an abbreviated version!
For detailed information about N-acetylneuraminate synthase, go to the full flat file.

Reaction

Synonyms

(NANA) condensing enzyme, EC 4.1.3.19, N-acetylneuraminate lyase synthase, N-acetylneuraminate pyruvate-lyase (pyruvate-phosphorylating), N-acetylneuraminic acid condensing enzyme, N-acetylneuraminic acid synthase, NANA condensing enzyme, NANA synthase, NANAS, NANS, NeuAc synthase, NeuB, NeuB1, NeuNAc synthase, NmeNANAS, sialic acid synthase, synthase, N-acetylneuraminate

ECTree

     2 Transferases

         2.5 Transferring alkyl or aryl groups, other than methyl groups

             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

                2.5.1.56 N-acetylneuraminate synthase

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Results	in table
1	Activating Compound
1671	AA Sequence
6	Application
1	CAS Registry Number
8	Cloned(Commentary)
3	Crystallization (Commentary)
10	Disease/ Diagnostics
14	General Information
3	General Stability
27	Inhibitors
1	Ki Value [mM]
18	KM Value [mM]
2	Localization
23	Metals/Ions
20	Molecular Weight [Da]
15	Natural Substrates/ Products (Substrates)
52	Organism
6	Pathway
7	PDB ID
7	pH Optimum
4	pH Range
9	pH Stability
29	Protein Variants
8	Purification (Commentary)
2	Reaction
3	Reaction Type
35	Reference
4	Source Tissue
12	Specific Activity [micromol/min/mg]
1	Storage Stability
47	Substrates and Products (Substrate)
20	Subunits
39	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
3	Temperature Range [°C]
9	Temperature Stability [°C]
8	Turnover Number [1/s]

Disease

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Disease on EC 2.5.1.56 - N-acetylneuraminate synthase

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DISEASE

TITLE OF PUBLICATION

LINK TO PUBMED

Down Syndrome

Manifold decrease of sialic acid synthase in fetal Down syndrome brain.

16729195

Infections

Cloning and expression of the human N-acetylneuraminic acid phosphate synthase gene with 2-keto-3-deoxy-D-glycero- D-galacto-nononic acid biosynthetic ability.

10749855

Intellectual Disability

The fate of orally administered sialic acid: First insights from patients with N-acetylneuraminic acid synthase deficiency and control subjects.

34258226

Meningococcal Infections

Design, synthesis, and structural elucidation of novel NmeNANAS inhibitors for the treatment of meningococcal infection.

31618227

n-acetylneuraminate synthase deficiency

The fate of orally administered sialic acid: First insights from patients with N-acetylneuraminic acid synthase deficiency and control subjects.

34258226

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