2.5.1.56: N-acetylneuraminate synthase

This is an abbreviated version!
For detailed information about N-acetylneuraminate synthase, go to the full flat file.

Word Map on EC 2.5.1.56

2.5.1.56

n-acetylmannosamine

antifreeze

mannac

meningitidis

polysialic

neunacs

neuroinvasive

synthesis

cmp-sialic

2-epimerase

ice-binding

Reaction

Synonyms

(NANA) condensing enzyme, EC 4.1.3.19, N-acetylneuraminate lyase synthase, N-acetylneuraminate pyruvate-lyase (pyruvate-phosphorylating), N-acetylneuraminic acid condensing enzyme, N-acetylneuraminic acid synthase, NANA condensing enzyme, NANA synthase, NANAS, NANS, NeuAc synthase, NeuB, NeuB1, NeuNAc synthase, NmeNANAS, sialic acid synthase, synthase, N-acetylneuraminate

ECTree

2 Transferases

2.5 Transferring alkyl or aryl groups, other than methyl groups

2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

2.5.1.56 N-acetylneuraminate synthase

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Results	in table
1	Activating Compound
1671	AA Sequence
6	Application
1	CAS Registry Number
8	Cloned(Commentary)
3	Crystallization (Commentary)
10	Disease/ Diagnostics
14	General Information
3	General Stability
27	Inhibitors
1	Ki Value [mM]
18	KM Value [mM]
2	Localization
23	Metals/Ions
20	Molecular Weight [Da]
15	Natural Substrates/ Products (Substrates)
52	Organism
6	Pathway
7	PDB ID
7	pH Optimum
4	pH Range
9	pH Stability
29	Protein Variants
8	Purification (Commentary)
2	Reaction
3	Reaction Type
35	Reference
4	Source Tissue
12	Specific Activity [micromol/min/mg]
1	Storage Stability
47	Substrates and Products (Substrate)
20	Subunits
39	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
3	Temperature Range [°C]
9	Temperature Stability [°C]
8	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 2.5.1.56 - N-acetylneuraminate synthase

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5-(carboxyamino)-3,5-dideoxy-2-O-phosphono-D-erythro-L-manno-nononic acid

Neisseria meningitidis

residues Glu25, Gln55, Asn74, Thr110, Phe112, Lys129, Asn184, Tyr186, Ser213, His215, Glu234, Phe288, and Arg314 amino acids are in close proximity and have essential interactions with the ligand

760046

5-acetamido-4,6,7,8,9-pentahydroxy-2-phosphorylnonanoic acid ditriethylammonium salt

Neisseria meningitidis

E0NCD4

4.5/1 mixture of 2S-inhibitor/2R-inhibitor, competitive inhibitor against phosphoenolpyruvate

AgNO3

1 mM, 61% inhibition

Co2+

stabilizes at low and inhibits at higher concentrations

737983

Cu2+

2 entries

EDTA

4 entries

ethyl 3-benzoyl-2,7-dimethyl indolizine-1-carboxylate

Neisseria meningitidis

inhibitor identified by molecular modeling. The compound shows important polar interactions with the Mn2+ ion, as well as with the Gln55, Asn184, and Arg314 residues

760046

Fe2+

Streptococcus agalactiae

1 mM FeCl2, 40% inhibition

637325

HgCl2

Escherichia coli

at 0.01 mM 85% inhibition, at 0.1 mM complete inhibition

hydroxylamine

1 mM, 23% inhibition

Iodine

1 mM, 30% inhibition

K+

Li+

Streptococcus agalactiae

1 mM LiCl, 30% inhibition

N-bromosuccinimide

1 mM, 24% inhibition

Na+

PCMB

1 mM, complete inhibition

637321

Phenylglyoxal

Streptococcus agalactiae

N-acetylmannosamine or phosphoenolpyruvate protect

Semicarbazide

1 mM, 20% inhibition

Zn2+

additional information

2 entries