2.5.1.56: N-acetylneuraminate synthase
This is an abbreviated version!
For detailed information about N-acetylneuraminate synthase, go to the full flat file.
Word Map on EC 2.5.1.56
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2.5.1.56
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n-acetylmannosamine
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antifreeze
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mannac
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meningitidis
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polysialic
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neunacs
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neuroinvasive
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synthesis
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cmp-sialic
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2-epimerase
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ice-binding
- 2.5.1.56
- n-acetylmannosamine
-
antifreeze
- mannac
- meningitidis
-
polysialic
-
neunacs
-
neuroinvasive
- synthesis
-
cmp-sialic
-
2-epimerase
-
ice-binding
Reaction
Synonyms
(NANA) condensing enzyme, EC 4.1.3.19, N-acetylneuraminate lyase synthase, N-acetylneuraminate pyruvate-lyase (pyruvate-phosphorylating), N-acetylneuraminic acid condensing enzyme, N-acetylneuraminic acid synthase, NANA condensing enzyme, NANA synthase, NANAS, NANS, NeuAc synthase, NeuB, NeuB1, NeuNAc synthase, NmeNANAS, sialic acid synthase, synthase, N-acetylneuraminate
ECTree
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Crystallization
Crystallization on EC 2.5.1.56 - N-acetylneuraminate synthase
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by small angle X-ray scattering and structure analysis, PDB ID 1XUZ
malate-bound enzyme and with phosphoenolpyruvate or the substrate analogue N-acetylmannosaminitol
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purified and concentrated enzyme crystallized at 18°C, hanging-drop vapor diffusion, 10 mM MnCl2, 1.50-1.55 M malic acid, pH 6.2, soaked in 2 M sodium phosphate, pH 6.2, with 10 mM MnCl2, 25% ethylene glycol, frozen in liquid nitrogen at -173°C, complex with Mn2+ and 4.5/1 mixture of 2S-inhibitor/2R-inhibitor