2.5.1.26: alkylglycerone-phosphate synthase

This is an abbreviated version!
For detailed information about alkylglycerone-phosphate synthase, go to the full flat file.

Reaction

Synonyms

3-deoxy-D-arabino-heptulosonate 7-phosphate synthase, ADPS, ADS, AGPS, alkyl DHAP synthetase, alkyl dihydroxyacetone phosphate synthase, alkyl dihydroxyacetone phosphate synthetase, alkyl-DHAP, alkyl-dihydroxyacetonephosphate synthase, alkyl-dihydroxyacetonephosphate-synthase, alkyldihydroxyacetone phosphate synthase, alkyldihydroxyacetonephosphate synthase, alkyldihydroxyacetonephosphate synthetase, alkylglycerone phosphate synthase, alkylglyceronephosphate synthase, DHAP-S, synthase, alkylglycerone phosphate, synthetase, alkyldihydroxyacetone phosphate

ECTree

     2 Transferases

         2.5 Transferring alkyl or aryl groups, other than methyl groups

             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

                2.5.1.26 alkylglycerone-phosphate synthase

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
3234	AA Sequence
6	Application
2	CAS Registry Number
11	Cloned(Commentary)
3	Cofactor
131	Disease/ Diagnostics
4	Expression
21	General Information
2	General Stability
19	Inhibitors
11	KM Value [mM]
25	Localization
5	Molecular Weight [Da]
6	Natural Substrates/ Products (Substrates)
43	Organism
3	Pathway
40	PDB ID
6	pH Optimum
1	pH Range
1	Posttranslational Modification
10	Protein Variants
8	Purification (Commentary)
8	Reaction
1	Reaction Type
43	Reference
39	Source Tissue
5	Specific Activity [micromol/min/mg]
3	Storage Stability
32	Substrates and Products (Substrate)
5	Subunits
38	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]

Substrates Products

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Substrates Products on EC 2.5.1.26 - alkylglycerone-phosphate synthase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide show all columns Go to Substrate/Product Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

1-acyl-glycerone 3-phosphate + a long-chain alcohol

an alkyl-glycerone 3-phosphate + a long-chain acid anion

2 entries

1-acylglycerone 3-phosphate + long-chain alcohol

alkylglycerone 3-phosphate + long-chain acid anion + H+

5 entries

1-O-hexadecyldihydroxyacetone phosphate + hexadecanol

long-chain acid anion + 1-O-hexadecyldihydroxyacetone phosphate

Cavia porcellus

-

-

489885

-

-

?

oleoyldihydroxyacetone phosphate + hexadecanol

oleate + 1-O-hexadecyldihydroxyacetone phosphate

Rattus norvegicus

-

-

489887

-

-

?

palmitoyldihydroxyacetone phosphate + hexadecanol

1-O-hexadecyldihydroxyacetone phosphate + palmitate

5 entries

palmitoyldihydroxyacetone phosphate + octadecanol

palmitate + 1-O-octadecyldihydroxyacetone phosphate

4 entries

stearoyldihydroxyacetone phosphate + hexadecanol

stearate + 1-O-hexadecyldihydroxyacetone phosphate

2 entries

stearoyldihydroxyacetone phosphate + octadecanol

stearate + 1-O-octadecyldihydroxyacetone phosphate

Rattus norvegicus

-

-

489887

-

-

?

additional information

additional information

-

6 entries

1-acyl-glycerone 3-phosphate + a long-chain alcohol

an alkyl-glycerone 3-phosphate + a long-chain acid anion

Homo sapiens

-

-

723024

-

-

?

1-acyl-glycerone 3-phosphate + a long-chain alcohol

an alkyl-glycerone 3-phosphate + a long-chain acid anion

Mus musculus

-

-

723024

-

-

?

1-acylglycerone 3-phosphate + long-chain alcohol

alkylglycerone 3-phosphate + long-chain acid anion + H+

Caenorhabditis elegans

-

-

489892

-

-

?

1-acylglycerone 3-phosphate + long-chain alcohol

alkylglycerone 3-phosphate + long-chain acid anion + H+

Mus musculus

-

1-acylglycerone 3-phosphate is acyldihydroxyacetone phosphate, the ester-linked fatty acid of the substrate is cleaved and replaced by a long-chain alcohol in the ether

489880

-

489880

?

1-acylglycerone 3-phosphate + long-chain alcohol

alkylglycerone 3-phosphate + long-chain acid anion + H+

Mus musculus

-

forms the ether bond found in alkyl and alk-1-enyl glycerolipids

489880, 489881

-

-

?

1-acylglycerone 3-phosphate + long-chain alcohol

alkylglycerone 3-phosphate + long-chain acid anion + H+

Mus musculus

-

first committed step in biosynthesis of ether-linked glycerolipids

489883

-

-

?

1-acylglycerone 3-phosphate + long-chain alcohol

alkylglycerone 3-phosphate + long-chain acid anion + H+

Rattus norvegicus

-

2 separate alkylglycerone-phosphate synthases, one in microsomes and another in peroxisomes might be engaged in biosynthesis of 1-O-alkylglycerolipids in rat liver

489886

-

-

?

palmitoyldihydroxyacetone phosphate + hexadecanol

1-O-hexadecyldihydroxyacetone phosphate + palmitate

Cavia porcellus

-

-

489885

-

-

?

palmitoyldihydroxyacetone phosphate + hexadecanol

1-O-hexadecyldihydroxyacetone phosphate + palmitate

Cavia porcellus

-

-

489882

-

489882

ir

palmitoyldihydroxyacetone phosphate + hexadecanol

1-O-hexadecyldihydroxyacetone phosphate + palmitate

Mus musculus

-

-

489880, 489881

-

-

?

palmitoyldihydroxyacetone phosphate + hexadecanol

1-O-hexadecyldihydroxyacetone phosphate + palmitate

Mus musculus

-

-

489883

-

489883

?

palmitoyldihydroxyacetone phosphate + hexadecanol

1-O-hexadecyldihydroxyacetone phosphate + palmitate

Rattus norvegicus

-

-

489885, 489886, 489887

-

-

?

palmitoyldihydroxyacetone phosphate + octadecanol

palmitate + 1-O-octadecyldihydroxyacetone phosphate

Caenorhabditis elegans

-

-

489892

-

-

?

palmitoyldihydroxyacetone phosphate + octadecanol

palmitate + 1-O-octadecyldihydroxyacetone phosphate

Cavia porcellus

-

-

489889, 489892

-

-

?

palmitoyldihydroxyacetone phosphate + octadecanol

palmitate + 1-O-octadecyldihydroxyacetone phosphate

Rattus norvegicus

-

-

489887

-

-

?

palmitoyldihydroxyacetone phosphate + octadecanol

palmitate + 1-O-octadecyldihydroxyacetone phosphate

Trypanosoma brucei

O97157

-

489891

-

-

?

stearoyldihydroxyacetone phosphate + hexadecanol

stearate + 1-O-hexadecyldihydroxyacetone phosphate

Rattus norvegicus

-

-

489887

-

-

?

stearoyldihydroxyacetone phosphate + hexadecanol

stearate + 1-O-hexadecyldihydroxyacetone phosphate

Trypanosoma brucei

O97157

-

489891

-

-

?

additional information

additional information

-

Cavia porcellus

-

overview on substrate specificity

489890

-

-

?

additional information

additional information

-

Homo sapiens

-

overview on substrate specificity

489890

-

-

?

additional information

additional information

-

Mus musculus

-

-

489890

-

-

?

additional information

additional information

-

Mus musculus

-

specific for acyldihydroxyacetone phosphate, acyldihydroxyacetone or 1-acyl-sn-glycerol 3-phosphate cannot substitute for acyldihydroxyacetone phosphate, the acyl group chain length in acyldihydroxyacetone phosphate should be C12 or longer

489881

-

-

?

additional information

additional information

-

Mus musculus

-

alkyldihydroxyacetone phosphate synthase also catalyzes the following reactions: 1. acyl exchange reaction in which palmitic acid is incorporated into palmitoyldihydroxyacetone phosphate, 2. alkyl exchange reaction in which hexadecanol is incorporated into hexadecyldihydroxyacetone phosphate

489880

-

-

?

additional information

additional information

-

Rattus norvegicus

-

-

489886

two reaction products: alkylglycerone phosphate and alkylglycerone, alkylglycerone phosphate is mainly synthesized by the peroxisomal synthase, whereas the inverse proportion is observed with the microsomal enzyme

489886

?