2.5.1.26: alkylglycerone-phosphate synthase
This is an abbreviated version!
For detailed information about alkylglycerone-phosphate synthase, go to the full flat file.
Word Map on EC 2.5.1.26
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2.5.1.26
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ether
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shikimate
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dah7ps
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chorismate
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plasmalogens
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chondrodysplasia
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rhizomelic
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punctata
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zellweger
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prephenate
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phenylalanine-sensitive
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dhap-at
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4.1.2.15
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tyrosine-sensitive
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8-phosphate
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hexadecanol
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5-enolpyruvylshikimate
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d-erythrose
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tryptophan-sensitive
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plasmalogen-deficient
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medicine
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dihydroxyacetone-phosphate
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pharmacology
- 2.5.1.26
- ether
- shikimate
- dah7ps
- chorismate
- plasmalogens
-
chondrodysplasia
-
rhizomelic
- punctata
- zellweger
- prephenate
-
phenylalanine-sensitive
- dhap-at
-
4.1.2.15
-
tyrosine-sensitive
-
8-phosphate
- hexadecanol
-
5-enolpyruvylshikimate
- d-erythrose
-
tryptophan-sensitive
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plasmalogen-deficient
- medicine
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dihydroxyacetone-phosphate
- pharmacology
Reaction
Synonyms
3-deoxy-D-arabino-heptulosonate 7-phosphate synthase, ADPS, ADS, AGPS, alkyl DHAP synthetase, alkyl dihydroxyacetone phosphate synthase, alkyl dihydroxyacetone phosphate synthetase, alkyl-DHAP, alkyl-dihydroxyacetonephosphate synthase, alkyl-dihydroxyacetonephosphate-synthase, alkyldihydroxyacetone phosphate synthase, alkyldihydroxyacetonephosphate synthase, alkyldihydroxyacetonephosphate synthetase, alkylglycerone phosphate synthase, alkylglyceronephosphate synthase, DHAP-S, synthase, alkylglycerone phosphate, synthetase, alkyldihydroxyacetone phosphate
ECTree
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General Information
General Information on EC 2.5.1.26 - alkylglycerone-phosphate synthase
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malfunction
metabolism
physiological function
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in plasmalogen-deficient Chinese hamster ovary mutant, ZPEG251, alkyl-dihydroxyacetonephosphate synthase, is defective. ADAPS mRNA is barely detectable by Northern blot and RT-PCR analyses. Defect of ADAPS expression is also assessed by immunoblot. Ectopic expression of ADAPS-EGFP, enhances the plasmalogen level
malfunction
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AGPS protein level and phosphatidylethanolamine plasmalogen level are decreased in amyloid-beta protein precursor-deficient cells and brains, overview
malfunction
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AGPS protein level and phosphatidylethanolamine plasmalogen level are decreased in amyloid-beta protein precursor-deficient cells and brains, overview
malfunction
cataracts and male infertility in blind sterile 2 (bs2) mice are caused by a spontaneous hypomorphic mutation in gene agp. Infertility in bs2 mice is due to the aberrant formation of multicellular cellular clusters that undergo apoptosis. The majority of Agps knock-out mice die embryonically. Correlations of RCDP3 and bs2 phenotypes, detailed overview
malfunction
knockdown of enzyme AGPS restores the drug sensitivity in glioma U-87MG/DDP and hepatic carcinoma Hep-G2/ADM cell lines. Silencing of AGPS leads to reduced cellular level of lysophosphatidic acid, lysophosphatidic acid-ether and prostaglandin E2, which can fuel aggressive and progress of cancer. Knockdown of AGPS also results in downregulation of multi-drug resistance proteins and anti-apoptosis proteins
malfunction
mutations in alkylglycerone phosphate synthase cause rhizomelic chondrodysplasia punctata, RCDP type 3 (RCDP3), a genetically heterogeneous autosomal recessive syndrome characterized by congenital cataracts, shortening of the proximal limbs, neurological abnormalities, seizures, growth delays, and severe intellectual disability. RCDP children die in the first decade of life due to respiratory complications, clinical phenotypes. Correlations of RCDP3 and bs2 phenotypes, detailed overview
malfunction
silencing of AGPS leads to reduced cellular level of lysophosphatidic acid, lysophosphatidic acid-ether and prostaglandin E2, which can fuel aggressive and progress of cancer. Effect of AGPS on adhesion, invasion and cell cycle of glioma and hepatic carcinoma cells, overview
malfunction
AGPS silencing suppresses the proliferation and migration potential of glioma U87MG cells, and suppresses the expression of the circular RNAs circ-ubiquitin-associated protein 2, circ-zinc finger protein 292 and circ-homeodomain-interacting protein kinase 3, and the long non-coding RNAs H19 imprinted maternally expressed transcript (non-protein coding), colon cancer-associated transcript 1 (non-protein coding) and hepatocellular carcinoma upregulated long non-coding RNA
malfunction
effects of AGPS silencing and knockout on circRNA expression in the thyroid cancer cell line FRO are investigated using circRNAs microarray
malfunction
knockdown of alkylglycerone-phosphate synthase leads to an overall reduction of ether lipid levels, as well as oncogenic signaling molecules, such as LPAe, PAFe and eicosanoids
malfunction
knockdown of alkylglycerone-phosphate synthase leads to an overall reduction of ether lipid levels, as well as oncogenic signaling molecules, such as LPAe, PAFe and eicosanoids, and it shows lower tumor growth rates in xenograft mice
malfunction
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cataracts and male infertility in blind sterile 2 (bs2) mice are caused by a spontaneous hypomorphic mutation in gene agp. Infertility in bs2 mice is due to the aberrant formation of multicellular cellular clusters that undergo apoptosis. The majority of Agps knock-out mice die embryonically. Correlations of RCDP3 and bs2 phenotypes, detailed overview
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alkyl-dihydroxyacetonephosphate-synthase, AGPS, is a rate limiting enzyme in plasmalogen synthesis, catalyzing the initial committed step in plasmalogen synthesis, phosphatidylethanolamine plasmalogen de novo synthesis, overview. Plasmalogens are major brain lipids
metabolism
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alkyl-dihydroxyacetonephosphate-synthase, AGPS, is a rate limiting enzyme in plasmalogen synthesis, catalyzing the initial committed step in plasmalogen synthesis, phosphatidylethanolamine plasmalogen de novo synthesis, overview. Plasmalogens are major brain lipids
metabolism
NF-kappaB and miR-127 may be the mediators of Tudor-SN-regulated AGPS via the mTOR signaling pathway
metabolism
positive correlation between the expression of alkylglycerone phosphate synthase (AGPS) and the malignant phenotype of thyroid cancer cell lines is identified. The inactivation of AGPS is able to decrease the malignancy of cancer, and inhibits tumor growth and invasion. AGPS is able to regulate the expression of circular RNAs (circRNAs), which may be the mechanism of its anticancer activity
Vitis vinifera x Vitis vinifera
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involved in aromatic amino acid metabolism
physiological function
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involved in aromatic amino acid metabolism
physiological function
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plasmalogens are decreased as a consequence of Alzheimer's disease and regulated by amyloid-beta precursor protein processing under physiological conditions. Under the pathological situation of Alzheimer's disease, increased amyloid-beta levels lead to increased reactive oxidative species production, reduced AGPS protein and plasmalogen level, overview. Alterations in amyloid precursor protein-dependent changes of AGPS expression result in reduced protein and plasmalogen levels
physiological function
enzyme AGPS negatively regulates the invasion potential of glioma and hepatic carcinoma cells by modulating the expression of relevant genes and activity of the MAPK pathway. The MAPK signaling pathway is an important cell signaling pathway, involved in the regulation of many fundamental cellular processes
physiological function
the enzyme catalyzes the critical step in ether lipid synthesis