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Literature summary for 2.5.1.26 extracted from

  • Zhu, Y.; Liu, X.J.; Yang, P.; Zhao, M.; Lv, L.X.; Zhang, G.D.; Wang, Q.; Zhang, L.
    Alkylglyceronephosphate synthase (AGPS) alters lipid signaling pathways and supports chemotherapy resistance of glioma and hepatic carcinoma cell lines (2014), Asian Pac. J. Cancer Prev., 15, 3219-3226.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
semiquantitative real-time PCR enzyme expression analysis Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information lentivirus-shRNA mediated AGPS silencing in Hep-G2/ADM and U-87MG/DDP cancer cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
peroxisome Uniprot Homo sapiens 5777
-

Organism

Organism UniProt Comment Textmining
Homo sapiens O00116
-
-

Source Tissue

Source Tissue Comment Organism Textmining
glioma cell
-
Homo sapiens
-
glioma cell line the enzyme is upregulated in multiple types of cancer cells and primary tumors Homo sapiens
-
Hep-G2/ADM cell a doxorubicin-resistant cell line Homo sapiens
-
hepatic carcinoma cell
-
Homo sapiens
-
hepatoma cell line the enzyme is upregulated in multiple types of cancer cells and primary tumors Homo sapiens
-
U-87MG/DDP cell a cisplatin-resistant cell line Homo sapiens
-

Synonyms

Synonyms Comment Organism
AGPS
-
Homo sapiens
alkylglyceronephosphate synthase
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the enzyme is upregulated in multiple types of cancer cells and primary tumors up

General Information

General Information Comment Organism
malfunction knockdown of enzyme AGPS restores the drug sensitivity in glioma U-87MG/DDP and hepatic carcinoma Hep-G2/ADM cell lines. Silencing of AGPS leads to reduced cellular level of lysophosphatidic acid, lysophosphatidic acid-ether and prostaglandin E2, which can fuel aggressive and progress of cancer. Knockdown of AGPS also results in downregulation of multi-drug resistance proteins and anti-apoptosis proteins Homo sapiens
physiological function the enzyme catalyzes the critical step in ether lipid synthesis Homo sapiens