2.5.1.26: alkylglycerone-phosphate synthase
This is an abbreviated version!
For detailed information about alkylglycerone-phosphate synthase, go to the full flat file.
Word Map on EC 2.5.1.26
-
2.5.1.26
-
ether
-
shikimate
-
dah7ps
-
chorismate
-
plasmalogens
-
chondrodysplasia
-
rhizomelic
-
punctata
-
zellweger
-
prephenate
-
phenylalanine-sensitive
-
dhap-at
-
4.1.2.15
-
tyrosine-sensitive
-
8-phosphate
-
hexadecanol
-
5-enolpyruvylshikimate
-
d-erythrose
-
tryptophan-sensitive
-
plasmalogen-deficient
-
medicine
-
dihydroxyacetone-phosphate
-
pharmacology
- 2.5.1.26
- ether
- shikimate
- dah7ps
- chorismate
- plasmalogens
-
chondrodysplasia
-
rhizomelic
- punctata
- zellweger
- prephenate
-
phenylalanine-sensitive
- dhap-at
-
4.1.2.15
-
tyrosine-sensitive
-
8-phosphate
- hexadecanol
-
5-enolpyruvylshikimate
- d-erythrose
-
tryptophan-sensitive
-
plasmalogen-deficient
- medicine
-
dihydroxyacetone-phosphate
- pharmacology
Reaction
Synonyms
3-deoxy-D-arabino-heptulosonate 7-phosphate synthase, ADPS, ADS, AGPS, alkyl DHAP synthetase, alkyl dihydroxyacetone phosphate synthase, alkyl dihydroxyacetone phosphate synthetase, alkyl-DHAP, alkyl-dihydroxyacetonephosphate synthase, alkyl-dihydroxyacetonephosphate-synthase, alkyldihydroxyacetone phosphate synthase, alkyldihydroxyacetonephosphate synthase, alkyldihydroxyacetonephosphate synthetase, alkylglycerone phosphate synthase, alkylglyceronephosphate synthase, DHAP-S, synthase, alkylglycerone phosphate, synthetase, alkyldihydroxyacetone phosphate
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Reference
Reference on EC 2.5.1.26 - alkylglycerone-phosphate synthase
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Hardeman, D.; Van den Bosch, H.
Rat liver dihydroxyacetone-phosphate acyltransferase: enzyme characteristics and localization studies
Biochim. Biophys. Acta
963
1-9
1988
Rattus norvegicus
Brown, A.J.; Snyder, F.
Alkyldihydroxyacetone-P synthase. Solubilization, partial purification, new assay method, and evidence for a ping-pong mechanism
J. Biol. Chem.
257
8835-8839
1982
Mus musculus
Brown, A.; Snyder, F.
Alkyldihydroxyacetonephosphate synthase
Methods Enzymol.
209
377-384
1992
Mus musculus
Horie, S.; Das, A.K.; Hajra, A.K.
Alkyldihydroxyacetonephosphate synthase from guinea pig liver peroxisomes
Methods Enzymol.
209
385-390
1992
Cavia porcellus
Brown, A.J.; Snyder, F.
The mechanism of alkyldihydroxyacetone-P synthase. Formation of [3H]H2O from acyl[1-R-3H]dihydroxyacetone-P by purified alkyldihydroxyacetone-P synthase in the absence of acylhydrolase activity
J. Biol. Chem.
258
4184-4189
1983
Mus musculus
Zomer, A.W.M.; de Weerd, W.F.C.; Langeveld, J.; van den Bosch, H.
Ether lipid synthesis: purification and identification of alkyl dihydroxyacetone phosphate synthase from guinea-pig liver
Biochim. Biophys. Acta
1170
189-196
1993
Bos taurus, Cavia porcellus, Homo sapiens, Pan troglodytes, Rattus norvegicus
Rabert, U.; Völkl, A.; Debuch, H.
Distribution of alkylglycerone-phosphate synthase in subcellular fractions of rat liver
Biol. Chem. Hoppe-Seyler
367
215-222
1986
Rattus norvegicus
Gunawan, J.; Rabert, U.; Völkl, A.; Debuch, H.
Kinetic studies of alkyl-dihydroxyacetone-phosphate (alkyl-glycerone-phosphate) synthase in peroxisomes of rat liver
Biol. Chem. Hoppe-Seyler
371
339-344
1990
Rattus norvegicus
Biermann, J.; Schoonderwoerd, K.; Hom, M.L.; Luthjens, L.H.; Van den Bosch, H.
The native molecular size of alkyl-dihydroxyacetonephosphate synthase and dihydroxyacetone phosphate acyltransferase
Biochim. Biophys. Acta
1393
137-142
1998
Cavia porcellus
De Vet, E.C.J.M.; Van Den Bosch, H.
Characterization of recombinant guinea pig alkyl-dihydroxyacetonephosphate synthase expressed in Escherichia coli. Kinetics, chemical modification and mutagenesis
Biochim. Biophys. Acta
1436
299-306
1999
Cavia porcellus
Van den Bosch, H.; de Vet, E.C.J.M.
Alkyl-dihydroxyacetonephosphate synthase
Biochim. Biophys. Acta
1348
35-44
1997
Cavia porcellus, Homo sapiens, Mus musculus
Zomer, A.W.M.; Opperdoes, F.R.; van den Bosch, H.
Alkyl dihydroxyacetone phosphate synthase in glycosomes of Trypanosoma brucei
Biochim. Biophys. Acta
1257
167-173
1995
Trypanosoma brucei (O97157), Trypanosoma brucei
De Vet, E.C.J.M.; Van den Bosch, H.
Alkyl-dihydroxyacetonephosphate synthase
Cell Biochem. Biophys.
32
117-121
2000
Caenorhabditis elegans, Cavia porcellus, Homo sapiens
-
Biermann, J.; Gootjes, J.; Wanders, R.J.A.; Van den Bosch, H.
Stability of alkyl-dihydroxyacetonephosphate synthase in human control and peroxisomal disorder fibroblasts
IUBMB Life
48
635-639
1999
Homo sapiens
De Vet, E.C.J.M.; Biermann, J.; Van Den Bosch, H.
Immunological localization and tissue distribution of alkyldihydroxyacetonephosphate synthase and deficiency of the enzyme in peroxisomal disorders
Eur. J. Biochem.
247
511-517
1997
Cavia porcellus
De Vet, E.C.J.M.; Ijlst, L.; Oostheim, W.; Wanders, R.J.A.; Van Den Bosch, H.
Alkyl-dihydroxyacetonephosphate synthase. Fate in peroxisome biogenesis disorders and identification of the point mutation underlying a single enzyme deficiency
J. Biol. Chem.
273
10296-10301
1998
Homo sapiens
Biermann, J.; Just, W.W.; Wanders, R.J.A.; Van den Bosch, H.
Alkyl-dihydroxyacetone phosphate synthase and dihydroxyacetone phosphate acyltransferase form a protein complex in peroxisomes
Eur. J. Biochem.
261
492-499
1999
Cavia porcellus
De Vet, E.C.J.M.; Hilkes, Y.H.A.; Fraaije, M.W.; Van den Bosch, H.
Alkyl-dihydroxyacetonephosphate synthase: Presence and role of flavin adenine dinucleotide
J. Biol. Chem.
275
6276-6283
2000
Cavia porcellus
Mueller, W.E.G.; Klemt, M.; Thakur, N.L.; Schroeder, H.C.; Aiello, A.; D'Esposito, M.; Menna, M.; Fattorusso, E.
Molecular/chemical ecology in sponges: evidence for an adaptive antibacterial response in Suberites domuncula
Mar. Biol.
144
19-29
2004
Suberites domuncula
-
Honsho, M.; Yagita, Y.; Kinoshita, N.; Fujiki, Y.
Isolation and characterization of mutant animal cell line defective in alkyl-dihydroxyacetonephosphate synthase: localization and transport of plasmalogens to post-Golgi compartments
Biochim. Biophys. Acta
1783
1857-1865
2008
Cricetulus griseus
Battilana, J.; Costantini, L.; Emanuelli, F.; Sevini, F.; Segala, C.; Moser, S.; Velasco, R.; Versini, G.; Stella Grando, M.
The 1-deoxy-D: -xylulose 5-phosphate synthase gene co-localizes with a major QTL affecting monoterpene content in grapevine
Theor. Appl. Genet.
118
653-669
2009
Vitis vinifera x Vitis vinifera, Vitis vinifera x Vitis riparia
Grimm, M.O.; Kuchenbecker, J.; Rothhaar, T.L.; Groesgen, S.; Hundsdoerfer, B.; Burg, V.K.; Friess, P.; Mueller, U.; Grimm, H.S.; Riemenschneider, M.; Hartmann, T.
Plasmalogen synthesis is regulated via alkyl-dihydroxyacetonephosphate-synthase by amyloid precursor protein processing and is affected in Alzheimers disease
J. Neurochem.
116
916-925
2011
Homo sapiens, Mus musculus
Zhu, Y.; Liu, X.J.; Yang, P.; Zhao, M.; Lv, L.X.; Zhang, G.D.; Wang, Q.; Zhang, L.
Alkylglyceronephosphate synthase (AGPS) alters lipid signaling pathways and supports chemotherapy resistance of glioma and hepatic carcinoma cell lines
Asian Pac. J. Cancer Prev.
15
3219-3226
2014
Homo sapiens (O00116)
Liegel, R.P.; Ronchetti, A.; Sidjanin, D.J.
Alkylglycerone phosphate synthase (AGPS) deficient mice: models for rhizomelic chondrodysplasia punctate type 3 (RCDP3) malformation syndrome
Mol. Genet. Metab. Rep.
1
299-311
2014
Homo sapiens (O00116), Homo sapiens, Mus musculus (Q8C0I1), Mus musculus, Mus musculus C57/BL6J (Q8C0I1)
Zhu, Y.; Zhu, L.; Lu, L.; Zhang, L.; Zhang, G.; Wang, Q.; Yang, P.
Role and mechanism of the alkylglycerone phosphate synthase in suppressing the invasion potential of human glioma and hepatic carcinoma cells in vitro
Oncol. Rep.
32
431-436
2014
Homo sapiens (O00116), Homo sapiens
Zhang, Y.; Jia, J.; Li, Y.; Chen, Y.G.; Huang, H.; Qiao, Y.; Zhu, Y.
Tudor-staphylococcal nuclease regulates the expression and biological function of alkylglycerone phosphate synthase via nuclear factor-kappaB and microRNA-127 in human glioma U87MG cells
Oncol. Lett.
15
9553-9558
2018
Homo sapiens (O00116), Homo sapiens
Yang, B.; Li, X.; He, L.; Zhu, Y.
Computer-aided design of temozolomide derivatives based on alkylglycerone phosphate synthase structure with isothiocyanate and their pharmacokinetic/toxicity prediction and anti-tumor activity in vitro
Biomed. Rep.
8
235-240
2018
Dictyostelium discoideum (O96759)
Stazi, G.; Battistelli, C.; Piano, V.; Mazzone, R.; Marrocco, B.; Marchese, S.; Louie, S.M.; Zwergel, C.; Antonini, L.; Patsilinakos, A.; Ragno, R.; Viviano, M.; Sbardella, G.; Ciogli, A.; Fabrizi, G.; Cirilli, R.; Strippoli, R.; Marchetti, A.; Tripodi, M.; Nomura, D.K.; Mattevi, A.; Mai, A.; Valent, V.a.l.e.n.t.e.
Development of alkyl glycerone phosphate synthase inhibitors Structure-activity relationship and effects on ether lipids and epithelial-mesenchymal transition in cancer cells
Eur. J. Med. Chem.
163
722-735
2019
Homo sapiens (O00116), Cavia porcellus (P97275)
Hou, S.; Tan, J.; Yang, B.; He, L.; Zhu, Y.
Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO
Oncol. Lett.
15
7889-7899
2018
Homo sapiens (O00116), Homo sapiens
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