2.4.2.14: amidophosphoribosyltransferase

This is an abbreviated version!
For detailed information about amidophosphoribosyltransferase, go to the full flat file.

Word Map on EC 2.4.2.14

2.4.2.14

purine

phosphoribosylamine

glutamine-dependent

glycinamide

6-diazo-5-oxo-l-norleucine

14cglycine

pp-ribose-p

acivicin

phosphoribosyltransferases

ribotide

p-rib-pp

Reaction

Synonyms

5'-phosphoribosylpyrophosphate amidotransferase, 5-phosphoribosyl-1-pyrophosphate amidotransferase, 5-phosphoribosylpyrophosphate amidotransferase, 5-phosphororibosyl-1-pyrophosphate amidotransferase, ADE4, alpha-5-phosphoribosyl-1-pyrophosphate amidotransferase, amido phosphoribosyltransferase, amidotransferase, phosphoribosyl pyrophosphate, APRT, ATASE, AtGPRT, Gln phosphoribosylpyrophosphate amidotransferase, glutamine 5-phosphoribosylpyrophosphate amidotransferase, glutamine phosphoribosyl pyrophosphate amidotransferase, glutamine phosphoribosylpyrophosphate amidotransferase, glutamine ribosylpyrophosphate 5-phosphate amidotransferase, GPAT, GPATase, GPRAT, GPRAT2, phosphoribose pyrophosphate amidotransferase, phosphoribosyl amidotransferase, phosphoribosyl pyrophosphate amidotransferase, phosphoribosylamidotransferase, phosphoribosyldiphosphate 5-amidotransferase, phosphoribosylpyrophosphate glutamyl amidotransferase, PPAT, PRAT, PurF

ECTree

2 Transferases

2.4 Glycosyltransferases

2.4.2 Pentosyltransferases

2.4.2.14 amidophosphoribosyltransferase

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Results	in table
6	Activating Compound
40826	AA Sequence
1	Application
1	CAS Registry Number
11	Cloned(Commentary)
1	Cofactor
6	Crystallization (Commentary)
79	Disease/ Diagnostics
1	Expression
4	General Information
15	General Stability
7	IC50 Value
107	Inhibitors
28	Ki Value [mM]
59	KM Value [mM]
7	Localization
44	Metals/Ions
42	Molecular Weight [Da]
21	Natural Substrates/ Products (Substrates)
56	Organism
11	Oxidation Stability
9	Pathway
30	PDB ID
12	pH Optimum
2	pH Range
25	Protein Variants
22	Purification (Commentary)
4	Reaction
4	Reaction Type
54	Reference
26	Source Tissue
12	Specific Activity [micromol/min/mg]
14	Storage Stability
71	Substrates and Products (Substrate)
9	Subunits
52	Synonyms
1	Systematic Name
9	Temperature Optimum [°C]
7	Temperature Stability [°C]
3	Turnover Number [1/s]

Oxidation Stability

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Oxidation Stability on EC 2.4.2.14 - amidophosphoribosyltransferase

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amido- and aminotransferase activity is lost after exposure to oxygen

Mus musculus

489754

anaerobic conditions stabilize

2 entries

in vitro O2 oxidizes iron in the Fe-S cluster to the high spin ferric state and sulfur to a mixtur of S in thiocystine residues plus other unidentified products

Bacillus subtilis

489755

low concentrations of thiols e.g. dithiothreitol or 2-mercaptoethanol accelerate aerobic inactivation

Escherichia coli

489747

O2, rather than peroxide, superoxide, hydroxyl radical or singlet oxygen, inactivates, allosteric inhibitors, such as AMP, ADP, GMP or GDP modulate the rate of inactivation

Bacillus subtilis

489753

oxygen inactivates during purification

Escherichia coli

489747

oxygen sensitive enzyme

3 entries

oxygen-labile in vivo and in vitro, AMP protects

Bacillus subtilis

489748