2.4.2.14: amidophosphoribosyltransferase

This is an abbreviated version!
For detailed information about amidophosphoribosyltransferase, go to the full flat file.

Reaction

Synonyms

5'-phosphoribosylpyrophosphate amidotransferase, 5-phosphoribosyl-1-pyrophosphate amidotransferase, 5-phosphoribosylpyrophosphate amidotransferase, 5-phosphororibosyl-1-pyrophosphate amidotransferase, ADE4, alpha-5-phosphoribosyl-1-pyrophosphate amidotransferase, amido phosphoribosyltransferase, amidotransferase, phosphoribosyl pyrophosphate, APRT, ATASE, AtGPRT, Gln phosphoribosylpyrophosphate amidotransferase, glutamine 5-phosphoribosylpyrophosphate amidotransferase, glutamine phosphoribosyl pyrophosphate amidotransferase, glutamine phosphoribosylpyrophosphate amidotransferase, glutamine ribosylpyrophosphate 5-phosphate amidotransferase, GPAT, GPATase, GPRAT, GPRAT2, phosphoribose pyrophosphate amidotransferase, phosphoribosyl amidotransferase, phosphoribosyl pyrophosphate amidotransferase, phosphoribosylamidotransferase, phosphoribosyldiphosphate 5-amidotransferase, phosphoribosylpyrophosphate glutamyl amidotransferase, PPAT, PRAT, PurF

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.2 Pentosyltransferases

                2.4.2.14 amidophosphoribosyltransferase

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Results	in table
6	Activating Compound
40826	AA Sequence
1	Application
1	CAS Registry Number
11	Cloned(Commentary)
1	Cofactor
6	Crystallization (Commentary)
79	Disease/ Diagnostics
1	Expression
4	General Information
15	General Stability
7	IC50 Value
107	Inhibitors
28	Ki Value [mM]
59	KM Value [mM]
7	Localization
44	Metals/Ions
42	Molecular Weight [Da]
21	Natural Substrates/ Products (Substrates)
56	Organism
11	Oxidation Stability
9	Pathway
30	PDB ID
12	pH Optimum
2	pH Range
25	Protein Variants
22	Purification (Commentary)
4	Reaction
4	Reaction Type
54	Reference
26	Source Tissue
12	Specific Activity [micromol/min/mg]
14	Storage Stability
71	Substrates and Products (Substrate)
9	Subunits
52	Synonyms
1	Systematic Name
9	Temperature Optimum [°C]
7	Temperature Stability [°C]
3	Turnover Number [1/s]

General Stability

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General Stability on EC 2.4.2.14 - amidophosphoribosyltransferase

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GENERAL STABILITY

ORGANISM

UNIPROT

LITERATURE

2-mercaptoethanol stabilizes during purification

Columba livia

-

489745

ADP or ADP and GMP, ratio 1/1, stabilize equilibrium between dimeric and tetrameric form

Bacillus subtilis

-

489748

AMP or GMP stabilizes dimeric enzyme form

Bacillus subtilis

-

489748, 489755

AMP stabilizes against inactivation by O2

Bacillus subtilis

-

489748, 489753

freezing inactivates, not stabilized by 30% glycerol

Glycine max

-

489760

GDP stabilizes tetrameric enzyme form

Bacillus subtilis

-

489748, 489755

high concentrations of thiol reagents stabilize during purification

Glycine max

-

489760

Mg2+ and phosphate are essential for stability

Homo sapiens

-

489757

phosphoribosyldiphosphate and other nucleotides antagonize stabilizing effect of AMP

Bacillus subtilis

-

489753

prolonged dialysis against distilled water leads to precipitation

Columba livia

-

489745

stability profile depends on growth rate and growth phase of cell culture, PMSF improves stability

Schizosaccharomyces pombe

-

489761

stable during all stages of purification provided thiols and oxygen are avoided

Escherichia coli

-

489747