2.4.1.88: globoside alpha-N-acetylgalactosaminyltransferase

This is an abbreviated version!
For detailed information about globoside alpha-N-acetylgalactosaminyltransferase, go to the full flat file.

Word Map on EC 2.4.1.88

2.4.1.88

glycolipids

fs

glycosyltransferases

histo-blood

transfusion

oligosaccharide

glycosphingolipids

n-acetylgalactosamine

galnac

gene-encoded

Reaction

N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide

N-acetyl-alpha-D-galactosaminyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide

Synonyms

acetylgalactosaminyltransferase, uridine diphosphoacetylgalactosamine-globoside alpha-, cis-AB-transferase, Forss-S, Forssman synthase, Forssman synthetase, Forssmann glycolipid synthetase, FS, GBGT1, globoside acetylgalactosaminyltransferase, globoside alpha-1,3-N-acetylgalactosaminyltransferase 1, glycosyltransferase 6 (GT6) family member, GT6m5, GT6m6, GT6m7, histo-blood group ABO system transferase, More, uridine diphosphoacetylgalactosamine-globoside alpha-acetylgalactosaminyltransferase

ECTree

2 Transferases

2.4 Glycosyltransferases

2.4.1 Hexosyltransferases

2.4.1.88 globoside alpha-N-acetylgalactosaminyltransferase

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Results	in table
15	Activating Compound
9	AA Sequence
1	CAS Registry Number
10	Cloned(Commentary)
1	Crystallization (Commentary)
10	Disease/ Diagnostics
2	Expression
4	General Information
4	General Stability
34	Inhibitors
1	Ki Value [mM]
6	KM Value [mM]
8	Localization
16	Metals/Ions
7	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
19	Organism
3	Pathway
6	pH Optimum
1	pH Range
2	Protein Variants
2	Purification (Commentary)
2	Reaction
1	Reaction Type
16	Reference
24	Source Tissue
5	Specific Activity [micromol/min/mg]
3	Storage Stability
24	Substrates and Products (Substrate)
2	Subunits
30	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]

Cloned

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Cloned on EC 2.4.1.88 - globoside alpha-N-acetylgalactosaminyltransferase

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cloned from cDNA library by PCR, expression, transcription and processing, of wild-type in COS-1 cells with and without HA-tag, but no detectable enzyme activity in the transfected cells by recombinant enzyme, DNA and amino acid sequence determination and analysis

Homo sapiens

Q8N5D6

489485

cloned in a eukaryotic expression vector and transfected into CHO cells

Rattus norvegicus

Q3L7L9, Q3L7M0

692523

DNA and amino acid sequence determination and analysis, stable expression in and functional complementation of Vero cells, which renders the cells resistant against the toxin

2 entries

expression in COS-1 cell

Homo sapiens

P16442

758457

expression in COS-1 cells with and without HA-tag

Canis lupus familiaris

489485

expression in COS-1 cells, DNA and amino acid sequence determination

Canis lupus familiaris

Q95158

489484

expression of wild-type in T42 human bladder and Vero monkey kidney epithelial cells, enables the cells to bind a canine Escherichia coli uropathogen, which they cannot bind without transfection

Canis lupus familiaris

489485

Gb4-synthase, expression in 1B9 mouse fibroblast L cells, coexpression of SV 40 large T antigen for extrachromosomal replication of the transfected plasmids

Homo sapiens

O75752

489386

gene GBGT1, quantitative RT-PCR enzyme expression profiling, high or intermediate levels of GBGT1 DNA methylation in all ovarian cancer cell lines (except for OVCAR3) but marginal levels of DNA methylation in the two normal ovary surface epithelial cell lines

Homo sapiens

Q8N5D6

735858