2.4.1.88: globoside alpha-N-acetylgalactosaminyltransferase

This is an abbreviated version!
For detailed information about globoside alpha-N-acetylgalactosaminyltransferase, go to the full flat file.

Word Map on EC 2.4.1.88

2.4.1.88

glycolipids

fs

glycosyltransferases

histo-blood

transfusion

oligosaccharide

glycosphingolipids

n-acetylgalactosamine

galnac

gene-encoded

Reaction

N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide

N-acetyl-alpha-D-galactosaminyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide

Synonyms

acetylgalactosaminyltransferase, uridine diphosphoacetylgalactosamine-globoside alpha-, cis-AB-transferase, Forss-S, Forssman synthase, Forssman synthetase, Forssmann glycolipid synthetase, FS, GBGT1, globoside acetylgalactosaminyltransferase, globoside alpha-1,3-N-acetylgalactosaminyltransferase 1, glycosyltransferase 6 (GT6) family member, GT6m5, GT6m6, GT6m7, histo-blood group ABO system transferase, More, uridine diphosphoacetylgalactosamine-globoside alpha-acetylgalactosaminyltransferase

ECTree

2 Transferases

2.4 Glycosyltransferases

2.4.1 Hexosyltransferases

2.4.1.88 globoside alpha-N-acetylgalactosaminyltransferase

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Results	in table
15	Activating Compound
9	AA Sequence
1	CAS Registry Number
10	Cloned(Commentary)
1	Crystallization (Commentary)
10	Disease/ Diagnostics
2	Expression
4	General Information
4	General Stability
34	Inhibitors
1	Ki Value [mM]
6	KM Value [mM]
8	Localization
16	Metals/Ions
7	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
19	Organism
3	Pathway
6	pH Optimum
1	pH Range
2	Protein Variants
2	Purification (Commentary)
2	Reaction
1	Reaction Type
16	Reference
24	Source Tissue
5	Specific Activity [micromol/min/mg]
3	Storage Stability
24	Substrates and Products (Substrate)
2	Subunits
30	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]

General Information

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General Information on EC 2.4.1.88 - globoside alpha-N-acetylgalactosaminyltransferase

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malfunction

Homo sapiens

Q8N5D6

GBGT1 expression is epigenetically silenced through promoter hypermethylation in ovarian cancer

735858

metabolism

Homo sapiens

Q8N5D6

the enzyme catalyzes the last step in the multi-step biosynthesis of the Forssman antigen, Fs antigen, a pentaglycosyl ceramide of the globo series glycosphingolipids. Involvement of DNA methylation in the synthesis of Fs antigen

735858

physiological function

Homo sapiens

P16442

the deletion of exon 3 or 4, but not of exon 2 or 5, of human GTA transcripts bestows moderate Forssman glycolipid synthase activity. Strong Forssman glycolipid synthase activity is attained, in addition to GTA and GTB activities, by cointroducing one of those deletions and the replacement of the LeuGlyGly tripeptide sequence at codons 266 to 268 by GlyGlyAla substitution, i.e. to the residues of Forssman glycolipid synthase

758457

additional information

2 entries